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NP-1815-PX

a P2X4 receptor antagonist

Also Known As:

5-(3-(5-thioxo-4H-(1,2,4)oxadiazol-3-yl)phenyl)-1H-naphtho(1, 2-b)(1,4)diazepine-2,4(3H,5H)-dione

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        NP-1815-PX: 3
  - Azepines: 11
    - NP-1815-PX: 3

Experts

1.	Antonioli, Luca: 1 article (08/2022)
2.	Benvenuti, Laura: 1 article (08/2022)
3.	Bertani, Lorenzo: 1 article (08/2022)
4.	D'Antongiovanni, Vanessa: 1 article (08/2022)
5.	Di Cesare Mannelli, Lorenzo: 1 article (08/2022)
6.	Di Salvo, Clelia: 1 article (08/2022)
7.	Fornai, Matteo: 1 article (08/2022)
8.	Ghelardini, Carla: 1 article (08/2022)
9.	Haskó, György: 1 article (08/2022)
10.	Lucarini, Elena: 1 article (08/2022)

Related Diseases

1.	Acute Pain 01/01/2016 - "Taken together, the newly developed P2X4R antagonist NP-1815-PX produces anti-allodynic effects in chronic pain models without altering acute pain sensitivity, suggesting that microglial P2X4R could be an attractive target for treating chronic pain."
2.	Chronic Pain 01/01/2016 - "Taken together, the newly developed P2X4R antagonist NP-1815-PX produces anti-allodynic effects in chronic pain models without altering acute pain sensitivity, suggesting that microglial P2X4R could be an attractive target for treating chronic pain." 01/01/2016 - "In in vivo assay for acute and chronic pain, intrathecal administration of NP-1815-PX produced an anti-allodynic effect in mice with traumatic nerve damage without affecting acute nociceptive pain and motor function (although its oral administration did not produce the effect). "
3.	Nociceptive Pain 01/01/2016 - "In in vivo assay for acute and chronic pain, intrathecal administration of NP-1815-PX produced an anti-allodynic effect in mice with traumatic nerve damage without affecting acute nociceptive pain and motor function (although its oral administration did not produce the effect). "
4.	Pain (Aches) 01/01/2016 - "Furthermore, in a mouse model of herpetic pain, P2X4R upregulation in the spinal cord exclusively occurred in microglia, and intrathecal NP-1815-PX suppressed induction of mechanical allodynia. "
5.	Inflammation (Inflammations) 08/01/2022 - "These changes were prevented by NC-2600 and NP-1815-PX treatment. For the first time, the above findings show that the selective inhibition of P2X4 receptors represents a viable approach to manage bowel inflammation via the inhibition of NLRP3 inflammasome signaling pathways."

Related Drugs and Biologics

1.	Occludin
2.	Purinergic P2X4 Receptors
3.	Inflammasomes
4.	Sulfonic Acids
5.	2,4-dinitrobenzene
6.	2,4-dinitrofluorobenzene sulfonic acid

Related Therapies and Procedures

1.	Oral Administration