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7- cysteine- 6,7- dihydro- 7- hydroxy- 1- hydroxymethyl- 5H- pyrrolizine

a pyrrolizidine alkaloid metabolite that forms adducts with DNA; structure in first source

Also Known As:

7-cysteine-DHP

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fu, Peter P: 3 articles (01/2020 - 01/2017)
2.	He, Xiaobo: 3 articles (01/2020 - 01/2017)
3.	Xia, Qingsu: 3 articles (01/2020 - 01/2017)
4.	Lin, Ge: 2 articles (01/2020 - 02/2019)
5.	Shi, Qiang: 1 article (01/2020)
6.	Tolleson, William H: 1 article (02/2019)
7.	Wu, Qiangen: 1 article (02/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "We previously determined that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP), 7-glutathione-DHP, 7-cysteine-DHP, 7-N-acetylcysteine-DHP, and 1-CHO-DHP are DNA reactive pyrrolic metabolites potentially associated with PA-induced liver tumor initiation. " 01/01/2017 - "These results suggest that 7-glutathione-DHP and 7-cysteine-DHP are reactive metabolites of PAs that can bind to cellular DNA to form DHP-DNA adducts in HepG2 cells, and can potentially initiate liver tumor formation."
2.	Carcinoma (Carcinomatosis) 02/01/2019 - "Here we showed that the four characteristic DNA adducts were formed when human A549 brochoalveolar carcinoma cells were treated with three dehydro-PAs (dehydroriddelliine, dehydromonocrotaline, or dehydroretronecine) or with 7-GS-DHP or 7-cysteine-DHP. "

Related Drugs and Biologics

1.	DNA Adducts
2.	DNA (Deoxyribonucleic Acid)
3.	7- glutathione- 6,7- dihydro- 7- hydroxy- 1- hydroxymethyl- 5H- pyrrolizine
4.	monocrotaline pyrrole
5.	dehydroretronecine
6.	1-CHO-DHP