methyl 2- (1- (4- fluorobenzyl)- 1H- indazole- 3- carboxamido)- 3- methylbutanoate

a synthetic cannabinoid; structure in first source

Also Known As:

AMB-FUBINACA; FUB-AMB; MMB-FUBINACA

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - Indazoles: 179
        methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate: 8
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indazoles: 179
      - methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate: 8
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Valine: 1999
      - methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate: 8
  - Essential Amino Acids: 1152
    - Valine: 1999
      - methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate: 8

Experts

1.	Gamage, Thomas F: 2 articles (01/2019 - 01/2018)
2.	Kevin, Richard C: 2 articles (01/2019 - 01/2018)
3.	Lefever, Timothy W: 2 articles (01/2019 - 01/2018)
4.	McGregor, Iain S: 2 articles (01/2019 - 01/2018)
5.	Thomas, Brian F: 2 articles (01/2019 - 01/2018)
6.	Wiley, Jenny L: 2 articles (01/2019 - 01/2018)
7.	Brito-da-Costa, Andreia Machado: 1 article (02/2021)
8.	Carmo, Helena: 1 article (02/2021)
9.	Carvalho, Félix: 1 article (02/2021)
10.	Dias-da-Silva, Diana: 1 article (02/2021)

Related Diseases

1.	Pica (Geophagia) 09/01/2019 - "Both cannabinoids were completely metabolized by human hepatocytes (12 and 8 metabolites were elucidated by high resolution mass spectrometry for 5F-APP-PICA and AMB-FUBINACA, respectively) and therefore suitable consumption markers are proposed. " 01/01/2019 - "Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures." 01/01/2018 - "Six synthetic cannabinoids, recently detected in illicit preparations, MMB-FUBINACA, MDMB-FUBINACA, CUMYL-PICA, 5F-CUMYL-PICA, NNEI, and MN-18 were assessed for: 1) receptor binding affinity at the human CB1 and human CB2 receptors, 2) function in [35S]GTPγS and cAMP signaling, and 3) THC-like effects in a mouse drug discrimination assay. "
2.	Substance-Related Disorders (Drug Abuse) 04/01/2019 - "A case of 5F-ADB / FUB-AMB abuse: Drug-induced or drug-related death?"
3.	Unconsciousness (Loss of Consciousness) 02/25/2021 - "ADB-FUBINACA and AMB-FUBINACA display full agonism of the CB1 receptor, this being responsible for their cardiovascular and neurological effects (e.g., altered perception, agitation, anxiety, paranoia, hallucinations, loss of consciousness and memory, chest pain, hypertension, tachycardia, seizures). "
4.	Tremor (Tremors) 01/01/2019 - "AMB-FUBINACA produced tremors at the highest dose tested. "
5.	Tachycardia (Tachyarrhythmias) 02/25/2021 - "ADB-FUBINACA and AMB-FUBINACA display full agonism of the CB1 receptor, this being responsible for their cardiovascular and neurological effects (e.g., altered perception, agitation, anxiety, paranoia, hallucinations, loss of consciousness and memory, chest pain, hypertension, tachycardia, seizures). "

Related Drugs and Biologics

1.	Cannabinoids
2.	Dronabinol (THC)
3.	5F-CUMYL-PICA
4.	CB1 Cannabinoid Receptor (CB1 Receptor)
5.	Cyanides (Isocyanides)
6.	Acids
7.	5F-ADB cannabinoid
8.	ADB-FUBINACA