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uvangoletin

antineoplastic from Sarcandra glabra

Also Known As:

zhongjiefeng

Networked: 6 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Biological Products
  - Plant Preparations: 622
    - Plant Extracts: 3916
      - Chinese Herbal Drugs: 73
        uvangoletin: 6
Pharmaceutical Preparations
- Chinese Herbal Drugs: 73
  - uvangoletin: 6

Experts

1.	Shen, Junyi: 1 article (01/2022)
2.	Shi, Yujun: 1 article (01/2022)
3.	Wen, Tianfu: 1 article (01/2022)
4.	Wu, Zhenru: 1 article (01/2022)
5.	Zhu, Xinrui: 1 article (01/2022)
6.	Dai, Xiaotian: 1 article (01/2021)
7.	Li, Yunsong: 1 article (01/2021)
8.	Lian, Xiaoyuan: 1 article (01/2021)
9.	Shi, Muran: 1 article (01/2021)
10.	Tang, Mingmin: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "This study aimed to investigate the anti-cancer effects of uvangoletin on HCC and to explore its underlying mechanisms. " 12/01/2008 - "The zhongjiefeng extracts significantly inhibit the growth of tumor compared to normal control group. " 02/01/2016 - "Further, the results of xenograft assay suggested that uvangoletin inhibited the HL-60-induced tumor growth without adverse effect on body weight of nude mice in vivo by regulating the expression levels of above apoptotic proteins. " 01/01/2021 - "Caffeic acid 3,4-dihydroxyphenethyl ester (CADPE) is a natural polyphenolic ester isolated as a minor component from a water extract of the Chinese medicine Zhongjiefeng [Sarcandra glabra (Thunb.) Nakai (Chloranthaceae)] and has previously shown to have activity against solid tumors through the modulation of multiple targets or signal pathways. "
2.	Vomiting 02/01/2016 - "The results indicated that the reductions of WBCs count and thighbone marrow granulocytes percentage in cyclophosphamide-induced leucopenia assay, the incubation period and number of emesis in copper sulfate-induced emesis assay and the gastric mucosal lesions in ethanol-induced gastric mucosal lesions assay were not exacerbated or reversed by uvangoletin. " 02/01/2016 - "This study investigated the cytotoxic effect of uvangoletin on HL-60 cells, and the effects of uvangoletin on myelosuppression, leucopenia, gastrointestinal tract disturbances and the possible cytotoxic mechanisms by using CCK-8, flow cytometry, western blot, xenograft, cyclophosphamide-induced leucopenia, copper sulfate-induced emesis and ethanol-induced gastric mucosal lesions assays. "
3.	Pharyngitis (Sore Throat) 01/01/2021 - "This study aimed to investigate the molecular mechanisms of compound herba Sarcandrae aerosol, also known as the Fufang Zhongjiefeng (FFZJF) aerosol, in treating chronic pharyngitis (CP) using network pharmacology and in vivo experimental approaches. " 01/01/2021 - "Network Pharmacology Analysis of the Mechanisms of Compound Herba Sarcandrae (Fufang Zhongjiefeng) Aerosol in Chronic Pharyngitis Treatment."
4.	Nasopharyngeal Carcinoma 12/01/2008 - "This study was designed to evaluate the effect of zhongjiefeng extracts on telomerase activity and apoptosis of implanted human nasopharyngeal carcinoma cell lines in nude mice. " 12/01/2008 - "[The inhibitory role of zhongjiefeng extracts, on apoptosis and telomerase activity of nasopharyngeal carcinoma cell line xenograft in nude mice]."
5.	Neoplasm Metastasis (Metastasis) 01/01/2022 - "Our results showed that uvangoletin could induce apoptotic and autophagic cell death, inhibit cell proliferation and metastasis on HepG2 cells through Akt/mTOR, MAPK and TGFβ/Smad2 signal pathways."

Related Drugs and Biologics

1.	Copper Sulfate (Sulfate, Copper)
2.	Telomerase (Telomerase Reverse Transcriptase)
3.	Sincalide
4.	Cyclophosphamide (Cytoxan)
5.	Ethanol (Ethyl Alcohol)
6.	Aerosols
7.	Proteins (Proteins, Gene)
8.	Esters
9.	caffeic acid 3,4-dihydroxyphenethyl ester
10.	flavone