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Telomerase (Telomerase Reverse Transcriptase)

An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.

Also Known As:

Telomerase Reverse Transcriptase; Telomerase Catalytic Subunit; Telomerase Reverse Transcriptase Catalytic Subunit; Catalytic Subunit, Telomerase; Reverse Transcriptase, Telomerase; Subunit, Telomerase Catalytic; Transcriptase, Telomerase Reverse

Networked: 5905 relevant articles (133 outcomes, 1035 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shay, Jerry W: 61 articles (09/2015 - 01/2002)
2.	Fujiwara, Toshiyoshi: 43 articles (07/2015 - 01/2004)
3.	Kyo, Satoru: 41 articles (05/2014 - 01/2002)
4.	Wright, Woodring E: 39 articles (09/2015 - 01/2002)
5.	Reddel, Roger R: 34 articles (06/2015 - 01/2002)
6.	Urata, Yasuo: 30 articles (07/2015 - 09/2004)
7.	Liu, Jun-Ping: 26 articles (12/2015 - 01/2002)
8.	Hiyama, Eiso: 26 articles (09/2012 - 01/2002)
9.	Blasco, Maria A: 23 articles (10/2015 - 05/2003)
10.	Shay, J W: 23 articles (02/2012 - 02/2000)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2004 - "This review summarizes the most promising results achieved by anti-telomerase strategy in different solid tumors. " 09/01/1998 - "To determine the best in vitro cell system for testing the efficacy of telomerase inhibitors, we evaluated the telomerase activity of various cancer cell lines and measured their telomere lengths. " 07/01/2014 - "These data indicate that downregulation of hTERT is an important part of the mechanism by which NaBu enhances ADR-induced apoptosis, and suggests that combining NaBu and ADR may be effective in treating uterine tumor with high telomerase activity." 08/04/2005 - "These results suggest that the lipid-conjugated thio-phosphoramidates could be important for improved pharmacodynamics of telomerase inhibitors in cancer therapy." 06/08/2005 - "The clinically important therapeutic agent VP-16-mediated prolonged cell arrest at G2-M phase prior to apoptotic death offered a different perspective in restraining human cancer cells at low drug dosage, thereby serving as an effective telomerase inhibitor as well as an apoptosis effector. "
2.	Carcinoma (Carcinomatosis) 04/01/2006 - "Telomerase may play an important role in the carcinogenesis of sebaceous gland carcinoma, and expression of hTR and hTRT combined with other features of sebaceous gland carcinoma may be helpful for the diagnosis and evaluation of clinical prognosis. " 01/01/2013 - "We detected a significant reduction of both TERT expression and telomerase activity in both HEK293 and MCF-7 breast carcinoma cells transfected with two pmGENIE-3 construct targeting distinct regions of TERT. " 08/01/2003 - "The expression of telomerase activity and its subunit level in pancreatic carcinoma significantly correlate with the clinical stage of pancreatic carcinoma and hence, may be helpful in its diagnosis and prognosis. " 11/06/2007 - "[The efficacy of autocatalytic casapse-3 driven by human telomerase reverse transcriptase promoter on human ovarian carcinoma]." 07/01/2005 - "The association of the hTERT protein with low stage urothelial carcinomas and improved patients' survival is in keeping with the idea that the early activation of telomerase may protect against genetic instability and the prevalence of aggressive malignant clones."
3.	Breast Neoplasms (Breast Cancer) 05/15/2006 - "Breast cancer cells that exhibited telomerase inhibition also exhibited significant reduction in colony formation and tumorigenicity. " 01/01/2009 - "The study demonstrated the potential of telomerase inhibition as an effective treatment for breast cancer. " 11/01/2009 - "GRN163L was effective in inhibiting telomerase activity and shortening telomeres in HER2-positive breast cancer cells. " 12/16/2011 - "We demonstrate the specific detection of as few as 30 telomerase-positive breast cancer cells in a single-measurement fluorescence assay that avoids the problematic PCR and gel analysis of the current "gold-standard" assay." 09/01/2012 - "In this study, we found that the human telomerase reverse transcriptase (hTERT; T) promoter also possesses high target specificity in breast cancer. "
4.	Leukemia 01/01/1998 - "Our results demonstrate that at diagnosis, telomerase was consistently and highly upregulated in BM and PB specimens in leukemia, decreased after induction therapy, and correlated with remission. " 11/28/2002 - "We analysed the short and long-term efficacy of a stably expressed dominant-negative mutant (DN) of the telomerase catalytic unit (hTERT) in UT-7 and U937 human leukemia cell lines by using an IRES-e-GFP retrovirus. " 08/01/2012 - "This study, the first to investigate the relationship between TERT methylation and telomerase activity in leukemia cells, demonstrated a differential methylation pattern and response to DAC in three AML cell lines. " 10/15/2008 - "In this study, we found that pectenotoxin-2 (PTX-2) decreased cell viability and inhibited telomerase activity with downregulation of hTERT expression in human leukemia cells. " 03/08/2008 - "In this study, we examined the effects of PD treatment on telomerase activity in different human leukemia cell lines. "
5.	Urinary Bladder Neoplasms (Bladder Cancer) 12/01/2000 - "Detection of telomerase activity in urine as a tool for noninvasive detection of recurrent bladder tumors is poor and cannot be improved by timing of sampling." 09/01/2000 - "The detection of telomerase activity and cellular apoptosis are helpful in clinical analysis and evaluation of prognosis of bladder cancer." 05/15/2008 - "In the present study, we show that the telomerase activity of T24-luc bladder cancer cells is inhibited by 1 microM GRN163L within 24 h of incubation. " 05/01/2008 - "This study was performed to evaluate the clinical utility of the measurement of the expression of telomerase enzyme (the catalytic subunit of the complex hTERT) and of the chromosomal analysis of urine by multicolor fluorescence in situ hybridization (M-FISH) assay for the detection of bladder cancer and its recurrence. " 07/01/2007 - "Previous studies have shown that telomerase activity in bladder washings and voided urine represents an important noninvasive tool for bladder cancer diagnosis. "

Related Drugs and Biologics

1.	Telomerase (Telomerase Reverse Transcriptase)
2.	Antigens
3.	Small Interfering RNA (siRNA)
4.	Cisplatin (Platino)
5.	imatinib (Gleevec)
6.	Oligonucleotides
7.	Messenger RNA (mRNA)
8.	telomerase RNA (bTR)
9.	RNA (Ribonucleic Acid)
10.	Biological Markers (Surrogate Marker)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunotherapy
3.	Therapeutics
4.	Radiotherapy
5.	Stem Cell Transplantation