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CLR1502

a tumor PET imaging agent; structure in first source

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - CLR1502: 3
Organic Chemicals: 133
- Amines: 4871
  - Quaternary Ammonium Compounds: 136
    - Trimethyl Ammonium Compounds: 1
      - Choline: 6256
        Phosphorylcholine: 752
        CLR1502: 3
- Onium Compounds
  - Quaternary Ammonium Compounds: 136
    - Choline: 6256
      - Phosphorylcholine: 752
        CLR1502: 3

Experts

1.	Weichert, Jamey P: 2 articles (02/2015 - 01/2014)
2.	Clark, Paul A: 1 article (02/2015)
3.	Farhoud, Mohammed: 1 article (02/2015)
4.	Kandela, Irawati K: 1 article (02/2015)
5.	Kuo, John S: 1 article (02/2015)
6.	Swanson, Kyle I: 1 article (02/2015)
7.	Zhang, Ray R: 1 article (02/2015)
8.	Albrecht, Dawn M: 1 article (01/2014)
9.	Clipson, Linda: 1 article (01/2014)
10.	Deming, Dustin A: 1 article (01/2014)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2015 - "This study demonstrates the potential use of CLR1501 and CLR1502 in fluorescence-guided tumor surgery." 02/01/2015 - "CLR1501 exhibits a tumor-to-brain fluorescence ratio similar to that of 5-ALA, whereas CLR1502 has a superior tumor-to-brain fluorescence ratio. " 02/01/2015 - "Near-infrared Fluobeam CLR1502 imaging in a mouse xenograft model demonstrated high- contrast tumor visualization compatible with surgical applications. " 01/01/2014 - "Peak tumor to background ratio occurred 2 days after injection with CLR1502. " 01/01/2014 - "Metastatic mesenteric tumors and uninvolved lymph nodes were detected with CLR1502. "
2.	Glioma (Gliomas) 02/01/2015 - "We developed and describe testing of 2 novel fluorescent, cancer-selective alkylphosphocholine analogs, CLR1501 (green) and CLR1502 (near infrared), in a proof-of-principle study for fluorescence-guided glioma surgery. "
3.	Intestinal Neoplasms (Intestinal Cancer) 01/01/2014 - "We investigated the use of CLR1502 for the detection of intestinal cancers in a murine model and 131I-CLR1404 in a patient with metastatic CRC. "
4.	Glioblastoma (Glioblastoma Multiforme) 02/01/2015 - "CLR1501, CLR1502, and 5-ALA were administered to mice with magnetic resonance imaging-verified orthotopic U251 glioblastoma multiforme- and glioblastoma stem cell-derived xenografts. " 02/01/2015 - "To demonstrate that CLR1501 and CLR1502 are cancer cell-selective fluorescence agents in glioblastoma models and to compare tumor-to-normal brain (T:N) fluorescence ratios with 5-ALA. "
5.	Colonic Neoplasms (Colon Cancer) 01/01/2014 - "Colon adenocarcinomas demonstrated increased accumulation of CLR1502 compared to non-invasive lesions (total radiant efficiency: 1.76×10(10) vs 3.27×10(9) respectively, p = 0.006). "

Related Drugs and Biologics

1.	Fluorescent Dyes (Fluorescent Probes)
2.	CLR1404