meserine

an acetylcholinesterase inhibitor; structure in first source

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

1.	Dementia (Dementias) 02/01/2014 - "In scopolamine-induced dementia mice, Meserine (1 mg/kg, i.p.) significantly ameliorated spatial learning and memory deficits, which was consistent with its in vitro inhibitory ability against AChE (recombinant human AChE, IC50 = 274 ± 49 nM). " 02/01/2014 - "Meserine, a novel carbamate AChE inhibitor, ameliorates scopolamine-induced dementia and alleviates amyloidogenesis of APP/PS1 transgenic mice."
2.	Alzheimer Disease (Alzheimer's Disease) 05/01/2014 - "Determination of Meserine, a new candidate for Alzheimer's disease in mice brain by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic and tissue distribution study." 02/01/2014 - "To investigate whether Meserine, a novel phenylcarbamate derivative of (-)-meptazinol, possesses beneficial activities against cholinergic deficiency and amyloidogenesis, the two major pathological characteristics of Alzheimer's disease (AD). "
3.	Memory Disorders (Memory Loss) 02/01/2014 - "In scopolamine-induced dementia mice, Meserine (1 mg/kg, i.p.) significantly ameliorated spatial learning and memory deficits, which was consistent with its in vitro inhibitory ability against AChE (recombinant human AChE, IC50 = 274 ± 49 nM). "

1.	Scopolamine (Hyoscine)
2.	Carbamates
3.	Cholinergic Agents (Cholinergics)
4.	Meptazinol