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Scopolamine (Hyoscine)

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An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.

Also Known As:

Hyoscine; Scopolamine Hydrobromide; Transderm Scop; Abbott Brand of Scopolamine Hydrobromide; Alcon Brand of Scopolamine Hydrobromide; American Pharmaceutical Partners Brand of Scopolamine Hydrobromide; Boro-Scopol; Bull Brand of Scopolamine Hydrobromide; Cooper Brand of Scopolamine Hydrobromide; Eifelfango Brand of Scopolamine Hydrobromide; Hamilton Brand of Scopolamine Hydrobromide; Hope Brand of Scopolamine; Hyocine Hydrobromide Injection BP; Hyoscine Injection BP; Inibisa Brand of Scopolamine Hydrobromide; Isopto Hyoscine; Kwells; Novartis Brand of Scopolamine; Novartis Consumer Health Brand of Scopolamine; Renaudin Brand of Scopolamine Hydrobromide; Roche Brand of Scopolamine Hydrobromide; Scoburen; Scopace; Scopoderm TTS; Scopolamine Cooper; Scopolaminum hydrobromicum; Transderm-V; Travacalm HO; Vorigeno; Winzer Brand of Scopolamine Borate; BP, Hyoscine Injection; Boro Scopol; BoroScopol; Hydrobromide, Scopolamine; Injection BP, Hyoscine; Transderm V; hydrobromicum, Scopolaminum; Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-

Networked: 1683 relevant articles (210 outcomes, 252 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Parle, Milind: 17 articles (03/2012 - 10/2003)
2.	Ryu, Jong Hoon: 11 articles (07/2015 - 08/2006)
3.	Kim, Young Choong: 9 articles (01/2013 - 01/2003)
4.	Lee, Ki Yong: 9 articles (11/2012 - 01/2003)
5.	Furey, Maura L: 8 articles (06/2015 - 10/2006)
6.	Nurten, Asiye: 8 articles (05/2015 - 09/2005)
7.	Blokland, Arjan: 7 articles (10/2015 - 12/2005)
8.	Drevets, Wayne C: 7 articles (06/2015 - 10/2006)
9.	Sung, Sang Hyun: 7 articles (01/2015 - 02/2005)
10.	Kim, Dong Hyun: 7 articles (07/2013 - 08/2006)

Related Diseases

1.	Amnesia (Dissociative Amnesia) 01/01/1993 - "MSF was highly effective in reducing scopolamine-induced amnesia." 01/01/2015 - "The hydroalcoholic extract of Emilia coccinae (HEEC) at the dose of 200 mg/kg significantly improved the memory of rats and reversed the amnesia induced by scopolamine. " 12/01/2014 - "Our results confirmed that AE showed significant improvement in cognitive deficit in scopolamine-induced amnesia animal model. " 03/25/2013 - "In vivo efficacy tested in scopolamine induced amnesia model indicated significant improvement in cognitive function in mice group treated with developed nanocarrier based formulations as compared to the control group." 01/01/2012 - "Cyclo(L-Phe-L-Phe) also significantly improved accuracy rates in a radial maze test in rats and increased step-through latencies in a passive avoidance test in mice with scopolamine-induced amnesia. "
2.	Motion Sickness (Airsickness) 08/01/2005 - "Scopolamine is highly effective for the treatment of seasickness. " 01/01/1996 - "A strong correlation was found between motion sickness and emetic sequelae after surgery, and patients with a history of motion sickness benefited most from hyoscine." 08/01/2005 - "Nevertheless, transdermal therapeutic system (TTS) scopolamine, despite high compliance on the part of persons treated by the drug, fails to provide protection against seasickness in 26-38% of patients. " 01/01/1987 - "We conclude that transdermal scopolamine's efficacy against seasickness during a 3-day cruise was not associated with significant side effects and, therefore, we find the drug suitable for long-term use by sailing crews." 01/01/1992 - "We conclude that buccal scopolamine is more effective than a placebo in treating ongoing motion sickness."
3.	Memory Disorders (Memory Loss) 11/01/2013 - "EUE significantly improved the impairment of short-term or working memory induced by scopolamine in the Y-maze and significantly reversed learning and memory deficits in mice as measured by the passive avoidance and Morris water maze tests. " 01/01/2006 - "DM (40 mg/kg i.p.) was effective in reversing the reference memory deficit induced by administration of scopolamine. " 01/12/2015 - "While orally RA administration (16 and 32 mg/kg) improved learning and memory in control rats, it reversed learning and memory deficits of scopolamine received groups. " 04/10/2014 - "Swimming improved the emotional memory by itself and restored the emotional memory deficit induced by the intra-CA1 injection of scopolamine. " 08/01/2013 - "PEBT improved memory deficits during consolidation and retrieval induced by scopolamine. "
4.	Nausea 02/01/1989 - "The number of patients reporting "zero nausea" was significantly greater with scopolamine patches than with placebo patches (13 vs 1, P less than 0.01). " 10/01/2013 - "The primary aim of this study was to clarify the effect of sublingual scopolamine on the intensity of nausea. " 10/01/2013 - "When the patients had nausea, they were administered a solution of scopolamine at 0.15 mg sublingually. " 06/01/2013 - "To prevent the participants of parabolic flights from nausea they are optionally treated with subcutaneously injected antiemetic scopolamine. " 07/01/2010 - "The scopolamine patch provides a moderate reduction in the nausea associated with UAE but is associated with infrequent but notable episodes of patient disorientation."
5.	Postoperative Nausea and Vomiting (PONV) 11/01/1991 - "Transderm scopolamine was effective in reducing but not eliminating postoperative nausea." 11/01/1991 - "A randomized prospective study of 201 patients in two institutions was performed to evaluate the efficacy of a transderm scopolamine patch in the control of postoperative nausea. " 01/01/2014 - "Clinical trials with transdermal scopolamine have consistently demonstrated its safety and efficacy in PONV. " 01/01/2008 - "Scopolamine for prevention of postoperative nausea in gynecologic laparoscopy, a randomized trial." 03/01/1996 - "In a prospective double-blind trial, transdermal scopolamine (TS) was compared to placebo (P) in the prevention of postoperative nausea and vomiting (PONV) within a 48-h interval. "

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4.	Physostigmine
5.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
6.	Soman
7.	Histamine (Histamine Dihydrochloride)
8.	Morphine (MS Contin)
9.	Dimenhydrinate (DMH)
10.	Dizocilpine Maleate (Dizocilpine)

Related Therapies and Procedures

1.	Oral Administration
2.	Analgesia
3.	Gynecologic Surgical Procedures (Gynecologic Surgery)
4.	Injections
5.	Intraperitoneal Injections