Abstract | OBJECTIVES: Redox regulation plays a crucial role in balancing the cardiovascular system. In this prospective study we aimed to identify currently unknown correlations valuable to cardiovascular research and patient management. METHODS: Blood samples from 500 patients were collected directly before cardiosurgical interventions (Ethics Committee reference number 85/11). Four central redox parameters were determined together with about 30 clinical, anthropometric, and metabolic parameters. RESULTS: DISCUSSION: In this prospective study we determined multiple correlations between redox markers and parameters linked to cardiovascular diseases. The data point towards so far unknown interdependencies, particularly between antihypertensive drugs and redox metabolism. A thorough follow-up to these data has the potential to improve patient management. ABBREVIATIONS:
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Authors | Anna Katharina Schuh, Babak Sheybani, Esther Jortzik, Bernd Niemann, Jochen Wilhelm, Andreas Boening, Katja Becker |
Journal | Redox report : communications in free radical research
(Redox Rep)
Vol. 23
Issue 1
Pg. 83-93
(Dec 2018)
ISSN: 1743-2928 [Electronic] England |
PMID | 29257712
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Antioxidants
- Biomarkers
- Calcium Channel Blockers
- Nitrites
- Glutathione Peroxidase
- Glutathione
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Adult
- Aged
- Aged, 80 and over
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Antioxidants
(analysis)
- Biomarkers
(blood)
- Calcium Channel Blockers
(therapeutic use)
- Cardiac Surgical Procedures
- Coronary Disease
(blood)
- Female
- Glutathione
(blood)
- Glutathione Peroxidase
(blood, metabolism)
- Humans
- Hypertension, Pulmonary
(blood)
- Male
- Middle Aged
- Nitrites
(blood)
- Oxidation-Reduction
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
(blood)
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