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DNA (Deoxyribonucleic Acid)

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Also Known As:
Deoxyribonucleic Acid; DNA, Double Stranded; ds-DNA; Double-Stranded DNA; ds DNA; DNA, Double-Stranded; Deoxyribonucleic acids
Networked: 145982 relevant articles (3446 outcomes, 14524 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Wang, Wei: 140 articles (08/2022 - 01/2002)
2. Zhang, Wei: 124 articles (06/2022 - 01/2002)
3. Wang, Jing: 99 articles (06/2022 - 07/2006)
4. Wang, Yan: 95 articles (11/2022 - 01/2002)
5. Li, Li: 90 articles (04/2022 - 10/2002)
6. Li, Wei: 89 articles (10/2022 - 01/2002)
7. Li, Yan: 89 articles (04/2022 - 05/2002)
8. Wang, Li: 86 articles (05/2022 - 06/2002)
9. Zhang, Li: 85 articles (06/2022 - 08/2002)
10. Li, Jun: 84 articles (01/2022 - 01/2002)

Related Diseases

1. Neoplasms (Cancer)
03/10/2022 - "SETD7 consistently prevented epithelial to mesenchymal transition in different cancer types, and inhibition of its function appears to be associated with improved response to DNA-damaging agents in most of the analysed studies. "
01/01/2017 - "The aim of this study is to determine the efficacy of combined DNA methylation analysis of a global DNA methylation marker - LINE-1 and a tumor suppressor gene highly associated with the malignancy of HCC- RASSF1A in serum as a novel prognostic marker for diagnosis of early recurrence after curative resection.LINE-1 was hypomethylated in 66.7% (70/105) and RASSF1A promoter was hypermethylated in 73.3% (77/105) of HCC serum DNA samples by methylation specific PCR, but in none of the healthy controls: LINE-1 hypometylation (0/50) and RASSF1A hypermethylation (0/50). "
09/01/2010 - "Consistent with the biological phenotype, epigenomic studies revealed that TRAMP; Dnmt1 hypomorphic mice show dramatically reduced CpG island and promoter DNA hypermethylation in late-stage primary tumors compared to control mice. "
11/01/2017 - "Somatic sequencing of mismatch repair genes from tumor DNA, whereas not currently available in most clinical laboratories, is helpful in resolution of cases in which germline sequencing fails to identify a mutation in a mismatch repair gene. "
11/01/2016 - "A systematic investigation of DSS has revealed that the tumor accumulation ability, internalization, and endosome escape of the DSS nanocarriers, DNA unpacking and nuclear transportation are all remarkably improved by the multi-responsive "turn-on" design resulting in highly efficient gene transfection in vitro and in vivo."
2. Infections
3. Chronic Hepatitis B
4. Aneuploidy (Aneuploid)
5. Breast Neoplasms (Breast Cancer)
12/14/2010 - "In striking contrast, we now show that 19 of 19 stage I breast tumors tested with the functional unscheduled DNA synthesis assay exhibited a significant deficiency of DNA nucleotide excision repair (NER) capacity relative to normal epithelial tissue from disease-free controls (n = 23). "
05/01/1994 - "The fraction of breast cancer cells undergoing DNA synthesis at any one time is relatively low, which is problematic because most chemotherapeutic agents are most effective against dividing cells. "
07/01/2021 - "Our results indicated a significant reduction in mt-DNA copy number in blood samples of breast cancer patients compared to control. "
01/01/2012 - "Met-DNA in serum detected with the OS-MSP assay constitutes a significant and independent prognostic factor, and its combination with total DNA in serum seems to be even more effective for prediction of prognosis for breast cancer patients."
09/01/2009 - "Using the MDA-MB-468 human breast cancer cell line in which ZRBA1 has already been reported to induce significant EGFR/DNA-targeting potency, the results showed that: (i) concurrent administration of ZRBA1 and 4 Gy radiation led to a significant decrease in cell viability, (ii) the greater efficacy of the combination was sequential, being limited to conditions wherein the drug was administered concurrently with radiation or before radiation, and (iii) the efficacy enhancement of the combination was further confirmed by clonogenic assays from which a dose enhancement factor of 1.34 could be observed at survival fraction of 0.01. "

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Vaccines
3. RNA (Ribonucleic Acid)
4. Hepatitis B e Antigens
5. Antigens
6. Methyltransferases
7. Hepatitis B Surface Antigens (HBsAg)
8. Antiviral Agents (Antivirals)
9. Biomarkers (Surrogate Marker)
10. Antibodies

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Radiotherapy
4. Immunotherapy
5. Aftercare (After-Treatment)