DNA (Deoxyribonucleic Acid)

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82644 relevant articles (1830 outcomes, 7877 trials/studies) found for this Bio-Agent

Description: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Also Known As:

Deoxyribonucleic Acid; B-DNA; B-Form DNA; DNA, Double Stranded; DNA, B-Form; ds-DNA; DNA, B Form; Double-Stranded DNA; DNA, Double-Stranded; Deoxyribonucleic acids

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1

DNA Transposable Elements: 530

Single-Stranded DNA: 438

Okazaki fragments: 11

ethidium-DNA complex: 1

calcium phosphate-DNA precipitate

CpG phosphodiester ODN 46-O

CpG phosphorothioate ODN 1826-S

deoxynucleic guanidine

luzopeptin-DNA complex

MB-FB molecular beacon

pentameric thymidyl deoxynucleic guanidine

PX65 paranemic crossover DNA molecule

Experts

1.	Lo, Y M Dennis: 23 articles (09/2008 - 01/2002)
2.	Chan, Anthony T C: 17 articles (08/2008 - 11/2002)
3.	Holzgreve, Wolfgang: 15 articles (03/2008 - 01/2002)
4.	Hahn, Sinuhe: 15 articles (03/2008 - 01/2002)
5.	Chan, Lisa Y S: 13 articles (12/2006 - 01/2002)
6.	Knuutila, S: 12 articles (11/2006 - 01/2000)
7.	Chan, K C Allen: 11 articles (09/2008 - 12/2002)
8.	Hirohashi, Setsuo: 11 articles (12/2007 - 09/2002)
9.	Kanai, Yae: 11 articles (12/2007 - 09/2002)
10.	Hoon, Dave S B: 10 articles (08/2008 - 03/2002)

Related Diseases

1.	Neoplasms (Cancer) 03/25/2005 - "These findings provide the molecular rationale for combining DNA damaging agents with RAD001, showing that a general effect on a major anabolic process may dramatically enhance the efficacy of an established drug protocol in the treatment of cancer patients with solid tumors." 10/20/2003 - "DNA minor groove binders (MGBs) are a class of anticancer agents highly effective in a variety of human cancers. " 11/01/2008 - "RESULTS: Vaccination of BALB/c mice with CTLA-4-ErbB2(222) plasmid DNA markedly improved tumor-free survival on challenge with ErbB2-expressing Renca cells in comparison with untargeted ErbB2(222), accompanied by induction of stronger ErbB2-specific antibody and CTL responses. " 10/01/2001 - "CONCLUSION: The technique using CK-gating markedly improved the SPF measurement in DNA diploid tumors. " 10/01/1999 - "Although illudins did not demonstrate significant activity as antiproliferative agents in tumor-bearing animals, several properties including its potent inhibition of DNA synthesis and a unique interaction with DNA led to a structure-activity-based synthetic effort to obtain analogs with improved therapeutic potential. " Order ALL the reference details at left...
2.	Infection 10/01/2003 - "New tools of coproantigen and copro-DNA detection for vulpine infections have proved highly beneficial in epidemiological and transmission ecology studies, as has a landscape ecology approach to develop risk models for communities in endemic areas. " 05/16/2003 - "In this study we evaluated the efficacy of DNA vaccination of IFN-gamma knockout (GKO) mice against Listeria monocytogenes, as these immunodeficient mice are highly susceptible to infection with low numbers of this intracellular bacterial pathogen. " 05/22/2000 - "These studies demonstrate that immunization with DNA encoding a type-specific gene may not be effective against either homologous or heterologous strains of virus, particularly if the challenge virus causes a highly lethal infection. " 01/26/2004 - "Sub-fragments of the envelope gene are highly protective against the Japanese encephalitis virus lethal infection in DNA priming--protein boosting immunization strategies." 03/01/2002 - "Three immunizations with either pp89, M84, or pp89 plus M84 DNA also provided significant protection against MCMV infection for at least 6 months, with the best protection produced by coimmunization. " Order ALL the reference details at left...
3.	Hepatitis B 01/27/2001 - "It is rapidly effective against virus replication since, after a one-month treatment, hepatitis B DNA levels are negative in most of the treated patients. " 08/01/2006 - "This first evaluation showed that DNA chip technology can provide important information in relation to the clinical management of chronic hepatitis B." 05/01/2009 - "Antiviral therapy against hepatitis B is effective in causing prolonged lowering of serum levels of hepatitis B virus DNA. " 12/01/2006 - "In conclusion, the quantitation of total and ccc HBV DNA in PBMCs is potentially useful as a non-invasive marker, and may help to increase our knowledge of the natural history of hepatitis B." 06/01/2005 - "CONCLUSIONS: These three sensitive assays, performed with the same DNA extraction, give clinicians useful information for the management of chronic hepatitis B and for timing treatment." Order ALL the reference details at left...
4.	Aneuploidy (Aneuploid) 09/01/1994 - "The aims of the study were: 1) to compare the sensitivity of FISH and DNA flow cytometry in aneuploidy detection, 2) to determine which chromosome copy number changes are most common, and 3) which probe combinations would be most effective in aneuploidy diagnosis. " 06/01/2002 - "When using tertiles as cutpoints for SPF classification, concordance rates ranged from 79.7% to 93.2% for DNA diploid samples and from 87.8% to 95.9% for DNA aneuploid samples, the best results being obtained with software working with a similar histogram resolution. " 09/15/1996 - "The DNA analysis of the cirrhotic cells showed that polyploidy was dramatically reduced in patients with HCC, compared with normal hepatocytes, and aneuploid clones were present among diploid cells. " 10/01/1987 - "Patients with rapidly proliferative diploid or DNA aneuploid tumours obtained complete remission more readily than patients with lowly proliferative diploid tumours. " 01/01/1990 - "DNA aneuploidy was not related with other clinically defined risk factors such as age, white blood cell count, and rapid achievement of remission. " Order ALL the reference details at left...
5.	DNA Damage 02/23/1998 - "The level of DNA damage produced by gamma-radiation was highly significant at doses of 0.5 and 1 Gy. Based on the mean extent of DNA migration, the level of damage was not reduced following only one hour of repair time however, after two hours, there was a significant reduction in DNA migration. " 09/01/1999 - "Addition of ascorbate to sperm preparation medium did not affect baseline DNA integrity but did provide sperm with complete protection against H(2)O(2)-induced DNA damage. " 03/01/2009 - "Groups V and VI showed a significant reduction in MeHg-induced genotoxicity (P < 0.001) when compared with group II. A negative correlation (r = -0.559, P < 0.05) was found between GSH-Px activity and DNA lesion, showing that the greater the DNA damage, the lower the GSH-Px activity. " 01/01/2009 - "pylori protection against oxidative stress-induced DNA damage, as the exposure of the HP1553 mutant cells to air for 6 h caused significant fragmentation of genomic DNA and led to cell death. " 09/01/1999 - "Although the evidence presented here is based on in vitro using isolated DNA, the results clearly demonstrate that the hot-water extract of Ganoderma lucidum shows good radioprotective ability, as well as protection against DNA damage induced by metal-catalyzed Fenton reactions and UV irradiation. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Antigens
2.	Hepatitis B e Antigens
3.	RNA (Ribonucleic Acid)
4.	Hepatitis B Surface Antigens (HBsAg)
5.	Vaccines
6.	Antibodies
7.	Lamivudine (3TC)
8.	Interferons
9.	Proteins (Proteins, Gene)
10.	Interleukin-12 (IL 12)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunotherapy
3.	Heterologous Transplantation (Xenotransplantation)
4.	Aftercare (After-Treatment)
5.	Transplantation (Transplant Recipients)

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