Coronary Artery Disease (Coronary Atherosclerosis)

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19596 relevant articles (814 outcomes, 3398 trials/studies) found for this Disease

Description: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.

Also Known As:

Coronary Atherosclerosis; Arterioscleroses, Coronary; Artery Disease, Coronary; Artery Diseases, Coronary; Atheroscleroses, Coronary; Coronary Arterioscleroses; Coronary Artery Diseases; Coronary Atheroscleroses; Disease, Coronary Artery; Diseases, Coronary Artery; Arteriosclerosis, Coronary; Atherosclerosis, Coronary; Coronary Arteriosclerosis

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 20552

Heart Diseases: 13044

Myocardial Ischemia: 13523

Coronary Disease: 15131

Coronary Artery Disease: 19596

Vascular Diseases: 7633

Myocardial Ischemia: 13523

Coronary Disease: 15131

Coronary Artery Disease: 19596

Arterial Occlusive Diseases: 1111

Arteriosclerosis: 2821

Coronary Artery Disease: 19596

Related Diseases

1.	Myocardial Infarction
2.	Heart Failure
3.	Myocardial Ischemia (Ischemic Heart Diseases)
4.	Hypertension (High Blood Pressure)
5.	Atherosclerosis (Atheroma)

Experts

1.	Serruys, Patrick W: 18 articles (09/2008 - 02/2002)
2.	Robbins, Robert C: 17 articles (11/2005 - 04/2002)
3.	Kastelein, John J P: 16 articles (09/2008 - 05/2004)
4.	Ohsuzu, Fumitaka: 16 articles (11/2006 - 01/2002)
5.	Aronow, Wilbert S: 15 articles (09/2008 - 06/2002)
6.	Blankenberg, Stefan: 15 articles (03/2008 - 01/2002)
7.	Wallentin, Lars: 14 articles (10/2008 - 05/2002)
8.	Anderson, Jeffrey L: 14 articles (06/2008 - 02/2002)
9.	Rupprecht, Hans J: 14 articles (03/2008 - 01/2002)
10.	Horne, Benjamin D: 14 articles (01/2008 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Coronary Artery Disease:

1.	CholesterolIBA 01/01/2005 - "Statins are cholesterol-lowering drugs, highly effective in the primary and secondary prevention of coronary artery disease. " 11/01/2000 - "Cholesterol management has clearly emerged as a top priority for prevention-oriented management of coronary artery disease, and National Cholesterol Education Program (NCEP) guidelines provide the best treatment targets for these efforts. " 03/01/1996 - "Serum cholesterol reduction is most effective for reducing cardiac events in patients with established coronary artery disease, yet surveys of cholesterol awareness and treatment have not included these patients. " 08/01/2005 - "BACKGROUND: Improved endothelial function may contribute to the beneficial effects of cholesterol lowering therapy in patients with coronary artery disease (CAD), but results of the effect of statin therapy on endothelial function are disparate in these patients. " 12/01/1999 - "This may suggest that these drugs could be beneficial in secondary prevention of coronary artery disease regardless of the serum cholesterol concentration." Order ALL the reference details at left...
2.	Lipoproteins (Lipoprotein)IBA 04/01/1993 - "Disorders associated with the overproduction or delayed clearance of beta-very low density lipoprotein and low density lipoprotein (LDL) are strikingly related to premature coronary artery disease. " 07/01/2000 - "Its high density lipoprotein-lowering effect, however, prevents it from being protective against progression of coronary atherosclerosis. " 04/01/2000 - "BACKGROUND AND AIM: Protection against coronary artery disease (CAD) by moderate alcohol consumption is thought to be partly mediated through an increase in high density lipoprotein (HDL) levels. " 10/01/1995 - "Epidemiological evidence suggests that plasma high-density lipoprotein (HDL) is protective against coronary artery disease, whereas oxidatively modified low density lipoprotein is atherogenic. " 05/01/1991 - "These data indicate that the clearance of postprandial lipoproteins in normolipidemic CAD patients as selected in the present study is delayed as compared with that of controls without coronary atherosclerosis and suggest that postprandial lipoproteins may play a role in the etiology of their disease." Order ALL the reference details at left...
3.	LDL CholesterolIBA 08/15/2007 - "High-dose statin treatment has been recommended as a primary strategy for aggressive reduction of LDL cholesterol levels and protection against coronary artery disease. " 07/01/2000 - "A substantial number of treated patients with or at high risk for coronary artery disease continue to have fatal and nonfatal coronary artery events in spite of significant reduction of elevated levels of low-density lipoprotein cholesterol. " 10/01/2008 - "Small LDL-cholesterol is superior to LDL-cholesterol for determining severe coronary atherosclerosis." 07/06/1998 - "Clinical and angiographic intervention trials have now ascertained that lowering LDL cholesterol is effective in prevention and in secondary treatment of coronary atherosclerosis. " 04/01/2002 - "Several adult clinical trials that included patients with DM have demonstrated the efficacy of lowering LDL-cholesterol in preventing death from coronary artery disease. " Order ALL the reference details at left...
4.	CalciumIBA 01/01/2001 - "Coronary calcium scores showed statistically significant differences between patients with angiographic evidence of coronary artery disease and patients with normal coronary angiography (p < 0.05), but could not differentiate between patients with significant and insignificant coronary artery disease. " 05/01/1996 - "Calcium antagonists may also be beneficial for diastolic left ventricular function in coronary artery disease. " 01/23/2004 - "Calcium antagonist and beta blocker regimens found equally effective in hypertensive patients with coronary artery disease." 07/01/1996 - "Calcium antagonists are effective in lowering blood pressure, relieving anginal symptoms and improving exercise tolerance in older and younger patients with coronary artery disease. " 09/01/1994 - "CONCLUSION: The electron beam CT calcium score appears to be an effective predictor of coronary artery disease." Order ALL the reference details at left...
5.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 04/01/2006 - "Secondary prevention of coronary events in coronary artery disease (CAD) patients with aspirin is generally accepted because of ease of administration, predictable safety, and proven efficacy. " 06/26/1997 - "The goals in management of chronic stable angina are (1) treatment of other conditions that may worsen angina; (2) treatment with aspirin and modification of risk factors for coronary artery disease (CAD) to improve outcome; and (3) effective relief of anginal symptoms. " 03/10/1979 - "The efficacy of aspirin treatment in coronary artery disease is not yet definitely established. " 11/01/2008 - "Aspirin is currently known to give inadequate protection against coronary artery disease in diabetes compared to person without it. " 07/01/2009 - "Studies were conducted in 1600 individuals (45.0+/-12.9 years, 42.7% male) at risk for coronary artery disease (CAD) before and after low dose aspirin. " Order ALL the reference details at left...
6.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 10/01/1990 - "Angiography is most helpful in aortic dissection with suspected brachiocephalic vessel involvement, coexistant coronary artery disease, or in cases of indeterminate CT. " 01/01/2005 - "Advances in spatial and temporal resolution, electrocardiographic triggering methodology, and image reconstruction software have helped in the evaluation of coronary artery anatomy and vessel patency, providing the ability to noninvasively diagnose or rule out significant epicardial coronary artery disease. " 02/01/1994 - "Screening for peripheral vessel changes indicative of high risk for coronary artery disease is possible and cost-effective with the noninvasive procedures now available." 01/01/2000 - "IVUS imaging provides a 2-dimensional, cross-sectional view into the lumen and vessel wall structure of coronary arteries; it is superior to angiography with regard to visualization about several aspects of coronary artery disease. " 06/01/1996 - "CABG is cost-effective for patients with severe angina and left main coronary artery disease and also for patients with mild angina and triple-vessel disease. " Order ALL the reference details at left...
7.	Dobutamine FDA LinkGeneric 12/01/2000 - "Prediction of improvement in global left ventricular function in patients with chronic coronary artery disease and impaired left ventricular function: rest thallium-201 SPET versus low-dose dobutamine echocardiography." 02/01/1996 - "Thus dobutamine echocardiography is superior to exercise electrocardiography for diagnosis of coronary artery disease in hypertensive patients." 04/01/2000 - "Dobutamine stress echocardiography is considered a relatively well-tolerated diagnostic modality, effective in the management of patients with known or suspected coronary artery disease. " 09/16/2008 - "Dobutamine stress echocardiography (DSE) has been shown to be a very useful non-invasive technique for the detection of coronary artery disease. " 11/01/2001 - "The aim of this study was to compare the efficacy of thallium-201 single-photon emission computed tomography (201Tl SPECT) coupled with exercise stress testing (EST), and dobutamine stress echocardiography (DSE) in the detection of asymptomatic coronary artery disease. " Order ALL the reference details at left...
8.	Perindopril FDA Link 09/06/2003 - "Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)." 04/01/2007 - "Efficacy of perindopril in reducing risk of cardiac events in patients with revascularized coronary artery disease." 04/01/2009 - "METHODS: The PERindopril GENEtic association study (PERGENE) is a substudy of the EUROPA trial, a randomized double-blind placebo-controlled multicentre clinical trial which demonstrated a beneficial effect of the ACE-inhibitor perindopril in reducing cardiovascular morbidity and mortality in 12.218 patients with stable coronary artery disease (mean follow-up 4.2 years). " 02/01/2009 - "BACKGROUND: The European trial on Reduction Of cardiac events with Perindopril in patients with stable coronary Artery disease (EUROPA) demonstrated the benefits of perindopril with respect to secondary prevention of cardiovascular risk in patients with stable coronary artery disease. " 01/01/2008 - "This study was a sub-study of the EUROPA (European Trial on Reduction of Cardiac Events with Perindopril in Stable Coronary Artery Disease) trial (n = 12,218; mean follow-up 4.2 years). " Order ALL the reference details at left...
9.	Nitroglycerin (Dynamite)FDA LinkGeneric 04/01/2007 - "DESIGN: Following an overnight fast we assessed percent improvement in endothelium-dependent FMD (%FMD) and endothelium-independent nitroglycerin (%NTG)-mediated vasodilation non-invasively in the brachial artery, using high resolution ultrasound in 11 non-treated adult patients with LS without known coronary artery disease, and compared them to 11 age- and sex-matched healthy controls. " 05/01/1989 - "The use of transdermal nitroglycerin (GTN) patches in patients with coronary artery disease is of uncertain value as numerous investigators have failed to confirm clinical efficacy for more than 8h. " 03/01/1983 - "The antianginal efficacy of a single sustained-release buccal nitroglycerin (BNTG) tablet was assessed in 16 patients with known coronary artery disease. " 08/01/1988 - "[Improvement in myocardial perfusion during exercise after nitroglycerin infusion in coronary artery diseases--evaluation by exercise thallium-201 scintigraphy]" 01/01/1975 - "Left ventricular wall motion abnormalities and ejection fraction improved in some coronary artery disease patients following nitroglycerin. " Order ALL the reference details at left...
10.	Dipyridamole (Persantine)FDA LinkGeneric 10/01/1995 - "In patients with chronic coronary artery disease and a low incidence of cardiac events, dipyridamole echocardiography was effective in prognostic stratification, and positive low work load exercise ECG results were a reliable predictor of subsequent events. " 07/15/1992 - "Intravenous dipyridamole planar thallium-201 imaging is a safe and effective test for detection and prognosis of coronary artery disease (CAD) in the general population. " 03/01/1997 - "Simultaneous dipyridamole/maximal subjective exercise with 99mTc-MIBI SPECT: improved diagnostic yield in coronary artery disease." 02/01/1992 - "To evaluate the efficacy of stress technetium-99m MMI (N-2-methoxy-2-methyl propyl isonitrile) myocardial perfusion scintigraphy (Tc-99m MMI) using intravenous dipyridamole for detection of coronary artery disease (CAD), we collected 66 cases (53 men, 13 women, aged 40-79 years old) between Sept. " 02/01/1988 - "Thus, dipyridamole cardiac imaging is helpful in the diagnosis of coronary artery disease and in risk stratification." Order ALL the reference details at left...

Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 10/01/1998 - "CONCLUSION: This study confirms the excellent clinical results of coronary artery bypass grafting (CABG) in patients with coronary artery disease and LV dysfunction; improvement in LV function can be documented objectively and is correlated with reperfusion of hibernating myocardium. " 05/01/2005 - "Coronary artery bypass grafting has proven a remarkably effective treatment for occlusive coronary artery disease, with demonstrable impact on both symptoms and survival. " 08/01/2004 - "Coronary artery bypass grafting (CABG) is known to be beneficial in patients with PXE-related coronary artery disease. " 06/01/1981 - "Six of the 10 patients with significant coronary artery disease had aortocoronary bypasses performed with good results. " 10/01/2008 - "In patients with coronary artery disease, the need for more accurately defined treatment recommendations based on the distribution of atherosclerotic disease has given rise to multiple trials designed to evaluate the efficacy of medical therapy versus percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). " Order ALL the reference details at left...
2.	Transplants (Transplant) 09/01/1990 - "Factors associated with improved 10-year actuarial survival included age younger than 65 years, mild angina, no major comorbidity, no left main coronary artery disease, good left ventricular performance, and an internal thoracic artery graft." 11/01/1986 - "We conclude the internal mammary graft gives better protection against the clinical manifestations of coronary artery disease than does the saphenous vein graft." 09/01/1987 - "Questions regarding the relative safety and efficacy of internal mammary artery (IMA) grafts versus saphenous vein grafts (SVG) in patients with left main coronary artery disease (LMCAD) have not been specifically addressed in the literature. " 09/01/1987 - "Safety and efficacy of internal mammary artery grafts for left main coronary artery disease. " 01/01/1994 - "Randomized studies of the efficacy of revascularization or medical therapy interventions in the nondiabetic renal transplant candidate with coronary artery disease have not been performed." Order ALL the reference details at left...
3.	Stents 05/01/2003 - "Stents have dramatically improved the treatment of coronary artery disease. " 09/01/2001 - "With late outcomes at least comparable to the best published results, this stent platform provides safe and effective percutaneous treatment of obstructive coronary artery disease. " 01/01/2005 - "Although the introduction of coronary stents has significantly improved the treatment of patients with coronary artery disease, restenosis, due to neointimal proliferation following stent deployment and associated with a return of ischemic symptoms, has remained a critical concern. " 01/01/2002 - "These results are indicative of high efficacy of surgical and endovascular (with implantation of stents) treatment of multivessel coronary artery disease." 08/01/2000 - "CONCLUSIONS: The GFX stent is a safe and effective device with a high procedural success rate and favorable late clinical outcome for treatment of native coronary artery disease. " Order ALL the reference details at left...
4.	Angioplasty (Angioplasties) 09/01/1997 - "Restenosis after coronary angioplasty is a major limitation of an otherwise highly effective and safe procedure for the treatment of atherosclerotic coronary artery disease. " 03/15/1992 - "Angioplasty is an effective treatment for proximal left anterior descending coronary artery disease that has a high success rate, low incidence of procedural complications and provides excellent long-term cardiac survival, freedom from cardiac events and sustained functional improvement." 06/01/1986 - "This favourable series demonstrates that nowadays with the improved technology and with a scrupulous pharmacological protocol transluminal coronary angioplasty can be performed with a low incidence of complications and excellent results, further assessing its high potential in the treatment of ischemic coronary artery disease." 06/01/2003 - "Furthermore, this program may be particularly beneficial for women with coronary artery disease who generally have higher mortality and morbidity than men after a heart attack, angioplasty, or bypass surgery." 02/01/1988 - "The efficacy of coronary angioplasty in multivessel coronary artery disease was evaluated in a series of 145 consecutive patients in whom angioplasty had been successful and in whom a follow-up exercise stress test was performed within 2 months. " Order ALL the reference details at left...
5.	Percutaneous Coronary Transluminal Angioplasty (PTCA) 11/01/1993 - "Restenosis after successful percutaneous transluminal coronary angioplasty remains a major clinical problem limiting the long-term efficacy of this treatment for coronary artery disease. " 05/01/1991 - "Restenosis after successful percutaneous transluminal coronary angioplasty is the major clinical problem limiting the long-term efficacy of this treatment for coronary atherosclerosis. " 12/01/1990 - "The high incidence of instant results of PTCA in patients with coronary artery disease and the favourable prognosis of long-term follow-ups are beneficial for proposers being accepted for life insurance, even though they belonged to the group of high-risk-patients before. " 01/01/1985 - "Rapid and progressive improvement in techniques and decreased morbidity and mortality rates have taken place since the introduction in 1977 of PTCA for the treatment of coronary artery disease. " 09/01/2004 - "Percutaneous transluminal coronary angioplasty improved long-term angina status more than medical therapy in coronary artery disease." Order ALL the reference details at left...

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