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Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)

A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020).
Also Known As:
Angiotensin Converting Enzyme; Angiotensin I-Converting Enzyme; Carboxycathepsin; Dipeptidyl Peptidase A; Kininase A; ACE1 Angiotensin Converting Enzyme 1; Angiotensin I Converting Enzyme; Carboxypeptidase I, Dipeptidyl; Peptidyl Dipeptidase A; ACE1 Angiotensin-Converting Enzyme 1; ACE1 Protein; Angiotensin Converting Enzyme 1; Antigens, CD143; CD143 Antigens; Dipeptidyl Carboxypeptidase I; Kininase II; Peptidase P
Networked: 10362 relevant articles (469 outcomes, 1689 trials/studies)

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Experts

1. Remuzzi, Giuseppe: 24 articles (10/2019 - 12/2001)
2. Yusuf, Salim: 23 articles (01/2019 - 01/2002)
3. Pfeffer, Marc A: 23 articles (04/2016 - 08/2003)
4. Bernstein, Kenneth E: 22 articles (01/2022 - 09/2004)
5. Solomon, Scott D: 21 articles (01/2022 - 11/2003)
6. McMurray, John J V: 18 articles (01/2022 - 09/2003)
7. Sturrock, Edward D: 17 articles (01/2022 - 01/2003)
8. Danilov, Sergei M: 17 articles (01/2021 - 12/2003)
9. Ruggenenti, Piero: 17 articles (01/2019 - 12/2001)
10. Zhou, Tian-Biao: 17 articles (06/2018 - 01/2011)

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4. Diabetic Nephropathies (Diabetic Nephropathy)
5. Left Ventricular Dysfunction

Related Drugs and Biologics

1. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
2. Angiotensin Receptor Antagonists
3. Angiotensin II
4. Captopril (Capoten)
5. Antihypertensive Agents (Antihypertensives)
6. Enalapril
7. Diuretics
8. Perindopril
9. Angiotensin Receptors (Angiotensin II Receptor)
10. Calcium

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4. Drug Therapy (Chemotherapy)
5. Surgical Instruments (Clip)