Abstract | BACKGROUND: METHODS: RESULTS:
Mood disorders are not associated with changes in IR or glucotoxicity, although the number of mood episodes may increase IR. 47.8% of the variance in HOMA-IR is explained by AOPP and body mass index (BMI, both positively) and NOx, Hp and TUD (all inversely). 43.2% of the variance in HOMA-B is explained by NOx, Hp and age (all inversely associated) and higher BMI and sex. The glucotoxic index is strongly associated with NOx, Hp and BMI (positively), male gender and lower education. LIMITATIONS: This is a cross-sectional study and therefore we cannot draw firm conclusions on causal associations. CONCLUSIONS: Activated IO&NS pathways (especially increased Hp and NOx) increase glucotoxicity and exert very complex effects modulating IR. Mood disorders are not associated with increased IR.
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Authors | Kamila Landucci Bonifácio, Décio Sabbatini Barbosa, Estefânia Gastaldello Moreira, Carine Coneglian de Farias, Luciana Higachi, Alissana Ester Iakmiu Camargo, Janaina Favaro Soares, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Michael Berk, Seetal Dodd, Michael Maes |
Journal | Journal of affective disorders
(J Affect Disord)
Vol. 222
Pg. 185-194
(11 2017)
ISSN: 1573-2517 [Electronic] Netherlands |
PMID | 28710952
(Publication Type: Journal Article)
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Copyright | Copyright © 2017. Published by Elsevier B.V. |
Chemical References |
- Biomarkers
- Blood Glucose
- Uric Acid
- Nitric Oxide
- C-Reactive Protein
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Topics |
- Adult
- Biomarkers
(blood)
- Bipolar Disorder
(blood)
- Blood Glucose
(analysis)
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Cross-Sectional Studies
- Depressive Disorder, Major
(blood)
- Female
- Humans
- Insulin Resistance
(physiology)
- Male
- Metabolic Syndrome
(blood, physiopathology, psychology)
- Middle Aged
- Nitric Oxide
(blood)
- Obesity
(blood, physiopathology, psychology)
- Tobacco Use Disorder
(blood, physiopathology)
- Uric Acid
(blood)
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