Nitric Oxide (Nitrogen Monoxide)

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18796 relevant articles (608 outcomes, 2389 trials/studies) found for this Drug

Description: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Also Known As:

Nitrogen Monoxide; Endogenous Nitrate Vasodilator; Mononitrogen Monoxide; Nitric Oxide, Endothelium-Derived; Endothelium-Derived Nitric Oxide; Monoxide, Mononitrogen; Monoxide, Nitrogen; Nitrate Vasodilator, Endogenous; Nitric Oxide, Endothelium Derived; Oxide, Nitric; Vasodilator, Endogenous Nitrate; Nitrogen oxide (NO)

Relationship Network

Drug Context: Research Results

Inorganic Chemicals: 6

Free Radicals: 5214

Nitric Oxide: 18796

glycosylated-nitric oxide complex hemoglobin A: 19

nitrosonium ion: 2

PAPA NONOate: 2

2-(dimethylamino)ethylputreanine-nitric oxide adduct: 1

methyl-N-2-dimethylaminoethyl-3-aminoproprionid-nitric oxide: 1

ethylputreanine-nitric oxide adduct

N(G)-hydroxy-arginine-nitric oxide adduct

nitric oxide scavenger 100

nitrosonium tetrafluoroborate

glycosylated-nitric oxide complex hemoglobin A: 19

nitrosonium ion: 2

PAPA NONOate: 2

2-(dimethylamino)ethylputreanine-nitric oxide adduct: 1

methyl-N-2-dimethylaminoethyl-3-aminoproprionid-nitric oxide: 1

ethylputreanine-nitric oxide adduct

N(G)-hydroxy-arginine-nitric oxide adduct

nitric oxide scavenger 100

nitrosonium tetrafluoroborate

Roussin's red salt

Experts

1.	Bloch, Kenneth D: 13 articles (10/2008 - 09/2002)
2.	Akyol, Omer: 13 articles (01/2007 - 01/2002)
3.	Rigas, Basil: 12 articles (11/2007 - 12/2002)
4.	Weinberg, J Brice: 11 articles (10/2008 - 01/2002)
5.	Finer, N N: 11 articles (01/2007 - 01/2000)
6.	Abman, Steven H: 10 articles (12/2007 - 01/2002)
7.	Barrington, K J: 10 articles (01/2007 - 01/2000)
8.	Barnes, P J: 10 articles (07/2005 - 01/2000)
9.	Zapol, Warren M: 9 articles (10/2008 - 09/2002)
10.	Gladwin, Mark T: 9 articles (08/2008 - 03/2003)

Related Diseases

1.	Pulmonary Hypertension (Ayerza Syndrome) 03/01/2003 - "BACKGROUND: Pulsed administration of nitric oxide has proven effective in relieving pulmonary hypertension and in improving oxygenation. " 09/01/1997 - "Recently it has been shown that inhaled nitric oxide (NO), which has been proven to contribute to improvement in critical pulmonary hypertension, may provide a favorable effect early after left ventricular assist device (LVAD) support. " 11/01/1999 - "CONCLUSIONS: Nitric oxide may be beneficial for patients with ACS because of its ability to ameliorate pulmonary hypertension and ventilation/perfusion mismatch. " 06/01/2008 - "In our setting, both drugs were effective in treating moderate persistent pulmonary hypertension of the neonate but nitric oxide (NO) treatment resulted in much faster amelioration of oxygenation index, taken as a marker of the underlying condition. " 11/01/2004 - "Inhaled nitric oxide (iNO) therapy is an effective treatment of pulmonary hypertension following left ventricular assist device (LVAD) implantation. " Order ALL the reference details at left...
2.	Anoxia (Hypoxia) 01/01/2003 - "A less marked decrease in this vascular reaction in patients with AH who live in high-altitude areas may be due to additional production and/or release of nitric oxide in order to increase the vasodilator reserve in moderate hypoxia. " 12/01/2006 - "Inhaled nitric oxide does not appear to be cost effective when treating hypoxemia in medical patients with high-risk scores and irreversible disease." 05/01/2001 - "As severe hypoxemia, we immediately started inhaled nitric oxide (iNO) that improved significantly pulmonary gas exchange. " 05/01/2007 - "[Nitric oxide is involved in the protective effects of short-term adaptaion to hypoxia in the course of stress-induced disorders in Krushinsky-Molodkina rats]" 10/01/1999 - "Adaptation to hypobaric hypoxia is known to exert multiple protective effects related with nitric oxide (NO). " Order ALL the reference details at left...
3.	Reperfusion Injury 01/01/2003 - "These findings support the role of nitric oxide as an important mediator in the protection against skin flap ischemia/reperfusion injury." 05/01/2004 - "Nitric oxide has been reported to be beneficial in preserving muscle viability following ischemia-reperfusion injury. " 04/15/1999 - "Thus, our results suggest that supplement of nitric oxide during reperfusion is effective in attenuating exocrine microvascular reperfusion injury." 03/01/2005 - "[The protective efficacy of rabbit endogenous nitric oxide against acute rabbit lung ischemia-reperfusion injury and its mechanism]" 12/01/1999 - "Conversely, protective effects of nitric oxide have been described in a number of pathological states, including hyperoxic and ischemia/reperfusion injury. " Order ALL the reference details at left...
4.	Ischemia 01/01/2006 - "CONCLUSION: The application of GTN, a nitric oxide donor, has caused significant improvement in renal function when applied prior to an experimentally designed renal ischemia-reperfusion model. " 02/27/2001 - "BACKGROUND: Although nitric oxide (NO) is thought to be beneficial in hepatic ischemia-reperfusion (I/R), the mechanisms for this effect are not well established. " 11/01/1993 - "Strategies designed to minimize postischemic attenuation of nitric oxide release may be beneficial in the management of acute limb ischemia." 09/01/2001 - "Inhibition of nitric oxide production during global ischemia ameliorates ischemic damage of pyramidal neurons in the hippocampus." 07/01/2001 - "Contribution of nitric oxide to the protective effects of ischemic preconditioning in ischemia-reperfused rat kidneys." Order ALL the reference details at left...
5.	Inflammation 03/01/2008 - "The body of published work on the role of exhaled nitric oxide (FENO) in the study of bronchial inflammation allows it to be classed as a simple, non-invasive measurement that is very useful in evaluating asthmatic patients. " 07/15/2001 - "Different authors have postulated both toxic and protective effects of nitric oxide (NO) in the pathophysiology of active inflammation. " 04/01/2000 - "BACKGROUND: Different authors have postulated both toxic and protective effects for nitric oxide (NO) in the pathophysiology of active inflammation. " 09/01/2006 - "CONCLUSIONS: Our findings suggest that lower serum UA levels in MS patients may represent a primary, constitutive loss of protection against nitric oxide and the development of CNS inflammation and tissue damage may not have a direct effect to UA serum levels. " 02/01/2006 - "OBJECTIVE: To investigate the efficacy of nitric oxide (NO) inhalation on lung function and modulation of inflammation in ventilated premature piglets. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Nitric Oxide Synthase (NO Synthase)
2.	Arginine (L-Arginine)
3.	NG-Nitroarginine Methyl Ester (L-NAME)
4.	Cytokines
5.	Epoprostenol (Prostacyclin)
6.	Oxygen
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
9.	Endothelin-1 (Endothelin 1)
10.	Glutathione (Reduced Glutathione)

Related Therapies and Procedures

1.	Extracorporeal Membrane Oxygenation (ECMO)
2.	Transplants (Transplant)
3.	Aftercare (After-Treatment)
4.	Lung Transplantation
5.	Cardiopulmonary Bypass (Heart-Lung Bypass)

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