Tobacco Use Disorder (Nicotine Dependence)

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989 relevant articles (75 outcomes, 167 trials/studies) found for this Disease

Description: Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.

Also Known As:

Nicotine Dependence; Dependence, Nicotine; Tobacco-Use Disorder; Dependence, Tobacco; Disorder, Nicotine Use; Disorder, Tobacco Use; Disorder, Tobacco-Use; Nicotine Use Disorders; Tobacco Dependences; Tobacco Use Disorders; Use Disorder, Nicotine; Nicotine Use Disorder; Tobacco Dependence

Relationship Network

Disease Context: Research Results

Disorders of Environmental Origin

Substance-Related Disorders: 6011

Tobacco Use Disorder: 989

Mental Disorders: 1850

Substance-Related Disorders: 6011

Tobacco Use Disorder: 989

Related Diseases

1.	Substance-Related Disorders (Drug Abuse)
2.	Substance Withdrawal Syndrome (Withdrawal Symptoms)
3.	Obesity
4.	Cocaine-Related Disorders (Cocaine Addiction)
5.	Weight Gain

Experts

1.	Li, Ming D: 8 articles (04/2007 - 05/2005)
2.	Ma, Jennie Z: 8 articles (04/2007 - 05/2005)
3.	Lerman, Caryn: 7 articles (11/2008 - 03/2004)
4.	Payne, Thomas J: 7 articles (04/2007 - 05/2005)
5.	Beuten, Joke: 7 articles (04/2007 - 05/2005)
6.	Wileyto, E Paul: 5 articles (11/2008 - 06/2005)
7.	Kendler, Kenneth S: 5 articles (07/2008 - 08/2004)
8.	Foulds, Jonathan: 5 articles (01/2007 - 05/2004)
9.	Chen, Xiangning: 4 articles (07/2008 - 08/2004)
10.	Markou, Athina: 4 articles (08/2007 - 11/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tobacco Use Disorder:

1.	Nicotine FDA Link 12/01/2005 - "Nicotine replacement therapies (NRT) are an effective treatment for tobacco dependence, yet most smokers do not quit or remain abstinent. " 01/01/2005 - "The effect of active NRT treatment did not differ significantly by smoking rate or nicotine dependence, with the exception that the nicotine patch was significantly more effective than placebo in highly dependent smokers. " 03/01/1996 - "CONCLUSION: Nicotine transdermal patches were most effective for smokers with moderate nicotine dependence and for younger smokers. " 01/01/2006 - "The invention of nicotine gum was a major treatment advance and also greatly helped our understanding of the nature of tobacco dependence. " 02/01/2001 - "CONCLUSION: Residential treatment for tobacco dependence is superior to outpatient treatment in some smokers who are moderately to severely nicotine dependent." Order ALL the reference details at left...
2.	Bupropion (Wellbutrin)FDA LinkGeneric 02/01/2004 - "OBJECTIVE: Bupropion SR has been shown to be effective for the treatment of nicotine dependence in adults. " 01/01/2002 - "Bupropion SR has also been found to be a useful treatment of tobacco dependence in various special populations of smokers who often experience difficulty in overcoming tobacco addiction. " 01/01/2004 - "The aim of the study was a one year evaluation of the efficacy of bupropion SR supported by an educational program in the treatment of nicotine dependence and analysis of the reasons of relapses. " 01/28/2009 - "Ongoing studies continue to explore the behavioural and pharmacological effects of bupropion in smoking cessation studies and animal models of nicotine dependence. " 06/01/2008 - "This study examined the psychometric properties of an Italian version of the Fagerström Test for Nicotine Dependence in a sample of 593 smokers who were enrolled in a randomized Phase IV clinical trial to compare bupropion to placebo. " Order ALL the reference details at left...
3.	varenicline (Chantix)FDA Link 05/01/2006 - "Phase II and III trials have yielded promising results suggesting that varenicline could be an important advance in the treatment of nicotine dependence." 09/01/2009 - "Varenicline, an alpha4beta2-nicotinic partial agonist, is effective for nicotine dependence. " 06/01/2009 - "Preliminary data from clinical trials have suggested that varenicline may be an effective therapy for tobacco dependence with minimal side effects. " 05/01/2009 - "Reduced affective symptoms during tobacco dependence treatment with varenicline." 03/01/2009 - "Recent meta-analyses have reviewed the newly Food and Drug Administration approved drug, varenicline, as well as some new nonpharmacological approaches to treating tobacco dependence. " Order ALL the reference details at left...
4.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 06/05/2009 - "Our analysis reveals significant evidence for at least four distinct loci in the nicotinic receptor subunit genes that each influence the transition from smoking to nicotine dependence and may inform the development of improved smoking cessation treatments and prevention initiatives." 08/01/2009 - "A recent genome-wide association study demonstrated an association between a common polymorphism (rs1051730) in the nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) and both smoking quantity and nicotine dependence. " 06/01/2008 - "Recent work from human genetics studies has provided evidence that neuronal nicotinic acetylcholine receptors (nAChR) genes may have a role in mediating early behaviors that are risk factors for alcohol and nicotine dependence, such as age of initiation and early subjective responses to the drugs. " 04/01/2008 - "Molecular biology studies suggest that the alpha(4)beta(2) nicotinic acetylcholine receptor subtype is the main receptor mediating nicotine dependence. " 01/01/2007 - "Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs." Order ALL the reference details at left...
5.	SmokeIBA 01/01/1992 - "Demographic characteristics (age, sex, site of employment) and smoking variables (number of years smoked, pretreatment number of cigarettes smoked per day, and nicotine dependence) failed to predict compliance, but complaint participants reported significantly greater confidence at their ability to not smoke in various challenging situations as measured by the Smoking Self Efficacy Questionnaire. " 06/01/2005 - "CONCLUSIONS: Smokers treated for nicotine dependence who stop smoking for a year report more improvement in-quality-of-life compared with those who continue to smoke." 08/01/2004 - "Efficacy of tobacco dependence treatment in the context of a "smoke-free grounds" worksite policy: a case study." 01/01/2008 - "BACKGROUND: Research supports the observation that "smokers drink and drinkers smoke." In this study, we aim to evaluate the relationship between nicotine dependence and the severity of anxiety and depression among alcohol dependent inpatients. " 09/01/2007 - "The purpose of this study was to examine tobacco dependence treatment practices among certified nurse-midwives who treat pregnant women who smoke. " Order ALL the reference details at left...
6.	Clonidine (ST 155)FDA LinkGeneric 05/20/1988 - "These findings, highly suggestive of an important role of clonidine in smoking cessation, warrant further studies to establish the long-term (greater than or equal to 12 months) efficacy of this drug and to replicate the association between nicotine dependence and depression." 12/01/1993 - "OBJECTIVE: This study examines the efficacy of clonidine in smoking cessation and the influence of gender, history of major depression, and measures of nicotine dependence. " 10/01/1993 - "After describing currently available pharmacotherapies, the article also describes several unexpected findings that need to be taken into consideration by clinicians: (a) transdermal nicotine is effective when given without psychological therapy, (b) transdermal nicotine and nicotine gum do not consistently decrease postcessation weight gain, (c) high level of nicotine dependence does not consistently predict better response to transdermal nicotine, and (d) clonidine is effective in women but not in men. " 02/01/1995 - "Clonidine, antidepressants, and buspirone require further study to determine what role, if any, they should play in the treatment of nicotine dependence. " Order ALL the reference details at left...
7.	Carbon MonoxideIBA 08/01/2009 - "The authors conclude that, while current treatments may potentially be effective for co-morbid ADHD and nicotine dependence, further research is needed to parse the complex associations between these disorders and prospectively study combined treatments." 04/01/2005 - "Study variables were age, sex, nicotine dependence (Fagerström Test), carbon monoxide in expired air, adherence to therapy, and smoking abstinence at 1 week, 1 month, 3 months (end of treatment), and 6 months. " 01/01/2005 - "When smoking abstinence was defined as having a breath carbon monoxide (CO) level <4 ppm within 24 hours of enrollment in the study, low nicotine dependence and a higher level of contemplation both predicted abstinence. " 01/01/2004 - "AIM: To study nicotine dependence (ND) basing on special questionnaires and measurement of CO concentrations in the exhaled air. " 09/01/2009 - "Nicotine dependence (ND) and major depression (MD) are highly prevalent disorders that frequently co-occur. " Order ALL the reference details at left...
8.	Cocaine (Cocaine HCl)IBA 01/01/1996 - "Clinical trials selected were those conducted for efficacy of acupuncture treatment with opiate, alcohol, cocaine and nicotine dependence." 01/01/2007 - "METHODS: We completed a genomewide linkage scan to map loci increasing risk for DSM-IV ND and for a quantitative assessment of ND as measured by the Fagerstrom Test for Nicotine Dependence (FTND) in a set of 634 small nuclear families ascertained on the basis of multiple individuals affected with cocaine or opioid dependence. " 06/01/2003 - "The sample was stratified into cocaine-positive and cocaine-negative groups based on admission urine drug screens, and relationships between nicotine dependence and outcome measures were examined in each group. " 06/01/2003 - "Standardized assessments of nicotine dependence (Fagerström Test for Nicotine Dependence; FTND), cocaine use, and personality were obtained for 105 African American cocaine-dependent outpatients. " 06/01/2003 - "We investigated whether severity of nicotine dependence was related to treatment outcome for cocaine-dependent individuals. " Order ALL the reference details at left...
9.	Chewing Gum (Chewing Gums)IBA 12/01/1987 - "The secondary effects of smoking cessation among subjects included in a randomized trial, performed to test the efficacy of acupuncture and nicotine chewing gum vs. the control group, are reported according to nicotine dependence. " 01/01/1985 - "Nicotine chewing gum in smoking cessation: efficiency, nicotine dependence, therapy duration, and clinical recommendations." 11/01/2003 - "Finally there are several strategies to deal with nicotine dependence, Nicotine Replacement Therapy (NRT), which are nicotine chewing-gum, transdermal nicotine patches, and nicotine inhalators device. " 01/01/1998 - "Diagnostic procedures including the Fagerström Test for Nicotine Dependence (FTND) and various modes of nicotine replacement therapy (chewing gum, plaster, nasal spray and inhaler) are described. " 04/01/2002 - "The conclusion reached is that the nicotine-containing chewing-gum "Nicorette" is a highly effective and safe medication that can come to be widely used for treating those patients who are prolonged and continuous users of tobacco and for preventing recurrences of nicotine dependence." Order ALL the reference details at left...
10.	Antidepressive Agents (Antidepressants)IBA 02/01/2002 - "Nicotine dependence: the role for antidepressants and anxiolytics." 06/01/2006 - "Given its attractive side effect profile, the efficacy of other newer antidepressants against hot flashes and anecdotal observations of resolution of hot flashes in some patients taking bupropion for nicotine dependence, it was decided to explore its clinical activity as a hot flash remedy in a pilot study. " 04/04/2005 - "The prescription of antidepressants for drug abuse seems only clear for nicotine dependence with or without previous comorbid depression (bupropion and nortryptiline). " 01/01/2008 - "The aim of this review is to consider the clinical trial evidence for the efficacy of four classes of pharmacological treatment for nicotine dependence: nicotine replacement, antidepressants, nicotine-receptor partial agonists and drugs blocking cannabinoid receptors. " 02/01/1995 - "Clonidine, antidepressants, and buspirone require further study to determine what role, if any, they should play in the treatment of nicotine dependence. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 09/01/2009 - "The effective treatment of tobacco dependence frequently requires tailoring, and often intensifying, interventions (both counseling and pharmacotherapy) to meet the needs of the individual patient." 01/01/2009 - "Pharmacotherapy can provide effective treatment of tobacco dependence and withdrawal, and thereby facilitate efforts to achieve and sustain tobacco abstinence. " 04/01/2008 - "Behavioral counseling and pharmacotherapies are available, safe, and effective in the treatment of tobacco dependence. " 09/15/2008 - "Although the efficacy of pharmacotherapy for tobacco dependence has been previously demonstrated, there is substantial variability among individuals in treatment response. " 05/01/2009 - "PURPOSE: A fraction of smokers considered eligible for pharmacotherapy treatment trials for nicotine dependence enrolled. " Order ALL the reference details at left...
2.	Self Administration (Administration, Self) 09/01/2003 - "Thus, animal models of nicotine dependence may need to be employed in conjunction with self-administration procedures in order to duplicate the effects of mecamylamine observed in studies of human smokers." 10/01/2000 - "The Flinders rats could be used as a model for nicotine self-administration studies to evaluate the susceptibilities of FSL and FRL rats to nicotine dependence." 03/01/1997 - "Animal models allow for analysis of anatomical and physiological mechanisms underlying nicotine self-administration; human studies validate the relevance to tobacco dependence and smoking cessation treatment." 10/01/2009 - "Increasing evidence indicates that smoking cues contribute to nicotine self-administration and attenuating conditioned reactivity to smoking cues may aid abstinence of smoking and prevention of smoking relapse in individuals with nicotine dependence. " 04/01/2004 - "Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats." Order ALL the reference details at left...
3.	Ear Acupuncture 09/01/2007 - "Modern research is confirming the efficacy of ear acupuncture for analgesia and anxiety related disease, while tobacco dependence and other substance abuse still need confirmation. " Order ALL the reference details at left...
4.	Analgesia 09/01/2007 - "Modern research is confirming the efficacy of ear acupuncture for analgesia and anxiety related disease, while tobacco dependence and other substance abuse still need confirmation. " Order ALL the reference details at left...
5.	Aftercare (After-Treatment) 01/01/2008 - "The purpose of this study was to examine the impact of depressive symptoms on abstinence from tobacco and alcohol after treatment for alcohol dependence and nicotine dependence. " 09/01/2003 - "This study examined baseline characteristics associated with abstinence from tobacco 6 months after treatment for nicotine dependence. " 01/01/2008 - "No increase in long-term risk for nicotine use disorders after treatment with methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD): evidence from a non-randomised retrospective study." Order ALL the reference details at left...

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