Abstract | BACKGROUND: Roux-en-Y bariatric surgery has been shown to have a remarkable and sustainable improvement in type 2 diabetes. Recent clinical studies have shown that bariatric surgery can improve or halt the development of diabetic microvascular complications such as nephropathy. However, the exact underlying mechanisms of surgical procedures are unknown. Here, we have investigated the effects of Roux-en-Y esophagojejunostomy (RYEJ) on renal function and inflammation and fibrosis biomarkers for renal injury in type 2 diabetic rats. METHODS: RESULTS: Roux-en-Y esophagojejunostomy improved insulin sensitivity. RYEJ ameliorated renal function by improving UAER and GFR and attenuated glomerular hypertrophy after surgery. RYEJ also significantly downregulated the levels of JNK-mediated inflammatory response and upregulated the level of the anti-inflammatory mediator MKP5. CONCLUSION: Roux-en-Y esophagojejunostomy alleviates insulin resistance. RYEJ surgery ameliorated renal function and attenuated glomerular hypertrophy in a DN rat model. The considerable nephroprotective function may be mainly attributed to the reduced inflammatory and fibrotic biomarkers after RYEJ. The improvements in renal function and inflammation are not wholly dependent on the magnitude of weight loss.
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Authors | Cuifang Wang, Bing He, Dongxu Piao, Ping Han |
Journal | Obesity surgery
(Obes Surg)
Vol. 26
Issue 7
Pg. 1402-13
(07 2016)
ISSN: 1708-0428 [Electronic] United States |
PMID | 26510754
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Anastomosis, Roux-en-Y
- Animals
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
(physiopathology)
- Fibrosis
(pathology)
- Inflammation
(metabolism)
- Kidney
(metabolism)
- Kidney Function Tests
- Male
- Obesity, Morbid
(surgery)
- RNA, Messenger
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Real-Time Polymerase Chain Reaction
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