Weight Loss (Weight Reduction)

1.	Reinehr, Thomas: 12 articles (06/2008 - 01/2004)
2.	Clifton, Peter M: 10 articles (03/2008 - 03/2004)
3.	Astrup, Arne: 9 articles (06/2008 - 09/2004)
4.	Klein, Samuel: 8 articles (06/2008 - 03/2003)
5.	Noakes, Manny: 8 articles (03/2008 - 03/2004)
6.	Roth, Christian L: 7 articles (06/2008 - 09/2005)
7.	Heymsfield, Steven B: 7 articles (01/2008 - 05/2002)
8.	Jatoi, Aminah: 7 articles (09/2007 - 01/2002)
9.	Nicklas, B J: 6 articles (10/2008 - 01/2000)
10.	Layman, Donald K: 6 articles (06/2008 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Weight Loss:

1.	Insulin (Novolin)FDA Link 05/01/2004 - "In agreement with these actions, it has been shown to be highly effective in the treatment of Type 2 diabetes, causing marked improvements in glycaemic profile, insulin sensitivity and beta-cell performance, as well as weight reduction" 05/01/2000 - "The blood pressure-lowering effect of weight loss is most likely a result of an improvement in insulin sensitivity and a decrease in sympathetic nervous system activity and occurs independent of salt restriction" 10/01/1981 - "Following a prolonged fast, obese diabetics show substantial improvement in most parameters of insulin function--an effect which is to some degree independent of weight loss; long-term remission of diabetes may be possible if the benefits of therapeutic fasting are conserved by appropriate eumetabolic measures." 03/01/2002 - "Improved aerobic fitness appeared to be the major difference between the two intervention groups, although weight loss and diet composition may have also played an important role in determining insulin sensitivity." 02/01/1996 - "CONCLUSION: In obese non-diabetic subjects the improvement in insulin sensitivity induced by weight loss was not accompanied by marked changes in skeletal muscle fiber composition or capillary density" Order ALL the reference details at left...
2.	Glucose (Dextrose)FDA LinkGeneric 09/01/2002 - "Higher preoperative fasting glucose best predicted the decrease in TG; improved HOMA %S with weight loss correlated best with HDL-C" 03/01/1990 - "After a 30-kg weight loss their glucose and lipid profiles were markedly improved but the thermic effect of glucose was still lower than that of the control subjects (4.2%, p less than 0.001)" 01/01/2003 - "Glycemic control improved in parallel with weight loss, and subjects who lost > or = 10% weight showed significant decreases in both HbA(1c) (1.2 +/- 0.4%, P < 0.0001) and fasting plasma glucose (1.8 mmol/l, P < 0.001)" 05/01/2008 - "From a therapeutic standpoint, lifestyle interventions such as dietary modification and/or exercise training have been shown to improve glucose homeostasis but may not normalize the disease process unless weight loss is achieved and increased physical activity patterns are established" 04/01/2006 - "A weight loss > 5% occurred in 64.6% of all patients, associated with improvement in glucose metabolism" Order ALL the reference details at left...
3.	sibutramine (Meridia)FDA Link 01/01/2003 - "The efficacy of sibutramine for inducing initial weight loss and the subsequent maintenance of weight loss is well proven in short- and long-term clinical trials of up to 2 years' duration" 02/01/1999 - "CONCLUSION: Following a very-low-calorie diet, sibutramine is effective in maintaining and improving weight loss for up to 1 year." 10/01/2007 - "However, there is some controversy as to whether weight loss is beneficial for health, and large clinical outcome trials such as the Look-AHEAD (Action for Health in Diabetes) trial or the SCOUT (Sibutramine Cardiovascular Outcomes Trial) study are currently ongoing" 01/01/2007 - "CONCLUSIONS: This study confirmed that sibutramine significantly enhances the effect of diet on weight loss, BMI and waist circumference reduction, and showed a significant improvement of QoL." 04/01/2000 - "Mean weight reduction from baseline was statistically significantly greater with sibutramine than with placebo at every measurement and at the end of the study (2.4 vs. 0.1 kg at week 12; p < 0.001; intent-to-treat)" Order ALL the reference details at left...
4.	orlistat (Xenical)FDA Link 01/01/1998 - "Orlistat, an inhibitor of pancreatic lipases, has proven effective for weight reduction in obese patients" 01/01/2006 - "The weight loss was significantly greater in the orlistat group than in the placebo group for the entire study period (P < 0.001)" 12/01/2005 - "RESULTS: Orlistat-treated patients achieved significantly greater weight loss at the study end than placebo-treated patients (-5.4 vs. -2.4 kg; P<0.0001)" 01/01/2003 - "In randomized, controlled trials of up to 2 years' duration, orlistat plus a hypocaloric diet produced significantly greater weight loss than placebo (P < 0.001)" 10/01/2000 - "In a series of 1- and 2-yr randomized, placebo-controlled trials of obese subjects, treatment with orlistat in combination with a mildly calorie-restricted diet consistently produced significantly greater mean weight loss than diet alone" Order ALL the reference details at left...
5.	CholesterolIBA 10/01/1986 - "The most improved group exhibited the following mean changes: weight loss of 9.2 kg, reductions in blood pressure of 12.9/8.8 mm Hg, improvement in aerobic capacity of 33%, reduction in serum cholesterol of 0.45 mmol/liter, and reduction in current overall CHD risk of 41%" 05/01/2008 - "The main results show that Intervention group (I) had a statistically significant improvement compared to Usual Care (UC) in the assumption of recommended quantity of fruit and vegetables (78.4% I vs 38.8% UC p=0.005), in the weight loss (weight loss > al 5% in subjects with BMI > 25 kg/m2) (16.5% I vs 6.8% UC p=0.005), in blood pressure control both in people specifically treated with drugs and untreated (respectively 52% I vs 35% UC p=0.04 and 65% Ivs 45% UC p=0.02), in reaching the European target for total cholesterol (Total Cholesterol < 5.0 mmol/l) during the study year (from 21.9% to 35.8% (I) absolute increase 12.7% (p=0.025) vs from 33% to 32.2% (UC))" 06/01/2007 - "Weight loss was associated with significant improvement in systolic blood pressure (-11 +/- 15 mmHg), diastolic blood pressure (-5 +/- 8 mmHg), and cholesterol (-0.7 +/- 1.3 mmol/l), even after adjustment for the use of medications (P < 0.001)" 11/01/2000 - "Culturally-sensitive weight loss program produces significant reduction in weight, blood pressure, and cholesterol in eight weeks." 05/01/1995 - "At follow-up, high active patients maintained significantly greater weight loss, had a lower percent regain and a significantly greater decrease in total cholesterol (P < 0.05) than less active patients" Order ALL the reference details at left...
6.	Carbon MonoxideIBA 06/01/2005 - "The small number of side effects and complications, the excellent weight loss and the recovery of most co-morbidity leads to a great improvement in quality of life." 11/01/2007 - "All co-morbidities resolved completely with the weight loss" 01/01/2007 - "The mean weight loss was 28.5 +/- 19.6 kg, and clinical re-evaluation revealed significant improvement in patient co-morbidity status (mean 2.23 +/- .7, range 1-3; P = .024)" 01/01/2007 - "In the short-term 3-year follow-up, no statistically significant difference was registered between AGB and VBG in terms of weight loss, reduction of co-morbidities, or improvement in quality of life" 04/01/2006 - "CONCLUSION: RYGBP achieved significant durable weight loss and effectively treated co-morbid conditions in SO and SSO patients with acceptable postoperative morbidity and slightly greater mortality than in MO patients." Order ALL the reference details at left...
7.	LeptinIBA 05/01/1998 - "Exogenous administration of leptin to ob/ob mice leads to a significant improvement in reproductive and endocrine status as well as reduced food intake and weight loss" 05/04/2007 - "Blocking central IL1 signaling also did not alter the re-feeding response to a prolonged fast, yet was entirely effective in preventing the anorexic effect of exogenously administered leptin (2 mg/kg ip, cumulative food intake at 18 h AdV-IL1ra 30.5+/-1.1 g vs. VEH 26.4+/-1.7 g, p<0.05) and prevented leptin-induced weight loss (AdV-IL1ra -0.1+/-1.3 g vs. VEH -2.7+/-1.9 g, p<0.05)" 04/01/2006 - "It has been shown that the administration of leptin in congenital leptin deficiency that there was improvement in satiety and weight loss" 11/01/2001 - "Administration of leptin to ob/ob mice led to improved reproduction as well as reduced feed intake and weight loss" 07/01/2008 - "Studies in rodents suggest that a reduction in leptin level during weight loss signals to the brain to increase feeding and decrease energy expenditure" Order ALL the reference details at left...
8.	SodiumIBA 08/01/1975 - "With 40 there was a significant weight loss, diuresis, natriuresis, and chloruresis over 24 hr. Comparison of the divided regimen with 40 mg daily revealed significantly greater sodium excretion, and chloride excretion with 20 mg twice daily" 01/01/1985 - "Improved BP control was strongly related to weight loss but not to reduced sodium excretion" 02/01/2007 - "In the study and MEDLINE groups, respectively mean days of admission were 3.39 and 11.7; mean serum sodium, 156.5 and 178.6 mEq/L; and mean % weight loss, 11.5 and 25.7" 11/01/2005 - "When achievement of sodium restriction, exercise, and weight loss goals were reached in the outpatient setting with subjects making their own food choices (as in the PREMIER study), adding the DASH diet with an average fruit and vegetable intake of 7.8 servings daily had no additional benefit in those younger than 50 years of age or in ethnic/gender subgroups, but did have a benefit for the total group older than age 50 years" 05/01/2001 - "Such studies confirm the blood pressure-lowering effects of sodium restriction, the consumption of diets that are low in fat and enriched in fruits and vegetables, and the sustained effects of weight reduction" Order ALL the reference details at left...
9.	LipidsIBA 12/01/1990 - "Very low calorie and carbohydrate diets may be beneficial for weight reduction in obese subjects without increasing blood lipids." 05/01/1994 - "However, controlling for the difference in weight loss, blacks sustained comparable improvement in lipids and blood pressure, except for TC/HDL-C (whites improved significantly more, -0.36 kg/m2, than blacks, 0.03 kg/m2)" 05/01/1998 - "OBJECTIVE: To study whether major weight loss causes sustained improvement in blood lipids and haemostatic profile in obese subjects, and to compare the influence of two different slimming and maintenance regimens" 05/01/1998 - "Sustained improvement in blood lipids, coagulation, and fibrinolysis after major weight loss in obese subjects." 04/01/1996 - "For those with raised lipids glycaemic control should be improved, if possible, and dietary therapy aimed at a decrease in fat intake, particularly saturated fat, and weight reduction in the obese" Order ALL the reference details at left...
10.	Metformin (Glucophage)FDA LinkGeneric 08/01/2004 - "Modest weight reduction was found in all treatment groups, with the most significant reduction occurring with the combination of metformin and lifestyle intervention" 06/01/2004 - "Metformin was more effective in promoting weight loss in patients with type 2 diabetes, although TZDs may decrease visceral fat levels" 09/01/2008 - "25.7), 439 patients (40%) who received treatment with diet alone, diet followed by metformin or metformin alone demonstrated a maintained weight reduction in addition to improved glycaemic control" 06/01/2008 - "Further research involving large-scale trials that evaluate weight loss as a primary outcome is necessary to firmly establish the role of metformin in this population." 01/01/2008 - "Similarly, metformin has been shown to induce weight loss in obese nondiabetic populations, although studies of long duration in this population are scarce" Order ALL the reference details at left...

Therapies and Procedures

1.	Bariatric Surgery 09/01/2007 - "RESULTS: Meta-analyses mainly based on case series data as well as controlled studies confirm that bariatric surgery is highly effective in obtaining weight reduction in morbidly obese patients up to 60% of the excess weight, along with resolution of preoperative diabetes in more than 75% of cases" 08/01/2008 - "Bariatric surgery is one of the most effective treatments for achieving long-term weight loss in morbidly obese patients" 08/01/2008 - "Traditional dietary and behavioral weight management methods have no demonstrated efficacy for extremely obese children and adolescents, in contrast with bariatric surgery which has produced significant and sustainable weight loss and associated improvements in comorbid diseases for the extremely obese" 12/01/2006 - "Bariatric surgery is the most effective treatment for achieving sustained weight loss in morbidly obese patients" 02/01/2006 - "BACKGROUND: Bariatric surgery is the most effective treatment for achieving long-term weight loss in morbidly obese patients" Order ALL the reference details at left...
2.	Gastric Bypass (Roux-en-Y Gastric Bypass) 10/01/2007 - "BACKGROUND: Laparoscopic gastric bypass, currently the most popular surgical method for bariatric therapy, have proved to be effective in weight loss, but some matters regarding its long-term efficacy for super-obese patients (BMI >50 kg/m2) have arisen" 07/01/1995 - "Most hepatic fatty change and probably some PSF occurring in morbidly obese persons is reduced or eliminated with weight loss following gastric bypass surgery." 02/01/2006 - "The primary aim of the study was to determine whether weight loss, achieved through Roux-en-Y gastric bypass (RYGBP), improved histopathology in obese patients with biopsy proven NASH" 06/01/2006 - "BACKGROUND: Laparoscopic gastric bypass (LGB) has proven efficacy in causing significant and durable weight loss" 07/01/2005 - "DISCUSSION: Our study shows improvement in all of the histological features of NAFLD after Roux-en-Y gastric bypass surgery-induced weight loss, despite significant histopathology at baseline and substantial weight loss." Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 01/01/2005 - "Most pharmacotherapies have demonstrated significantly greater weight loss in patients on active treatment than those receiving placebo in short-term (<or=1 year) randomised controlled trials of pharmacological treatment in conjunction with a calorie-controlled diet or lifestyle intervention" 12/01/2001 - "When medically indicated, pharmacotherapy may be used for weight loss, but pharmacotherapy appears to be most effective when used in combination with modifications of both eating and exercise behaviors" 11/01/1980 - "Patients on chemotherapy did not have a significantly greater incidence of aversions, weight loss, decreased appetite, or early satiety than patients not receiving chemotherapy" 12/01/2005 - "Pharmacotherapies are effective in inducing some weight loss; however, lost weight is regained once the medications are stopped" 03/01/1997 - "Studies have shown that pharmacotherapy, combined with classical treatment strategies, has improved the long-term maintenance of weight loss." Order ALL the reference details at left...
4.	Gastroplasty (Vertical-Banded Gastroplasty) 08/10/1991 - "It is concluded that vertical banded gastroplasty in our hands seems a relatively safe and effective surgical method of achieving sustained weight loss in most patients." 10/01/1990 - "Significant weight loss achieved with gastroplasty results in increased ventricular compliance and improved cardiac function." 04/01/1987 - "Weight losses were significantly greater in the vertical type, while there were no significant differences among the horizontal types of gastroplasty" 06/01/2005 - "BACKGROUND: The authors evaluated the predictive efficacy of preoperative resting energy expenditure (REE) on long-term weight loss maintenance following vertical banded gastroplasty (VBG)" 09/01/2001 - "OBJECTIVE: To evaluate the predictive efficacy of preoperative resting energy expenditure (REE) on weight loss after vertical banded gastroplasty (VBG)" Order ALL the reference details at left...
5.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 07/01/2002 - "There were no serious adverse effects, but the possibility of adverse effects in the 10 subjects who did not adhere to the program cannot be eliminated.A very low carbohydrate diet program led to sustained weight loss during a 6-month period" 11/15/2004 - "The high-protein, low-carbohydrate diet is effective for weight loss over the short term, but its long-term benefits remain unproved" 01/01/1981 - "The weight loss observed during the carbohydrate-restricted diets was significantly greater than during the high-carbohydrate diet" 01/01/2003 - "Studies examining the efficacy of using low-carbohydrate diets for long-term weight loss are few in number, however few positive benefits exist to promote the adoption of carbohydrate restriction as a realistic, and more importantly, safe means of dieting" 10/01/2005 - "DISCUSSION: The low-carbohydrate diet was not more cost-effective for weight loss than the standard diet in the patient population studied" Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Weight Loss

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 1131 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>