Obesity, inflammation and metabolic syndrome in Danish adolescents.

Abstract

AIM:

To describe biomarkers of inflammation and markers related to the metabolic syndrome (MS) in healthy obese Danish adolescent and compare to a normal-weight group.

METHODS:

Fifty-one obese and 30 normal-weight adolescents (12-15 years) were included. Anthropometry and blood pressure were measured, and blood was sampled.

RESULTS:

Obese adolescents had significantly higher blood pressure, insulin, homeostasis model assessment of insulin resistance, C-peptide, total cholesterol, low-density lipoprotein cholesterol (LDL), triglyceride, C-reactive protein (CRP), interleukin-6 and tumour necrosis factor alpha and lower high-density lipoprotein cholesterol values, compared with normal-weight adolescents, whereas there were no differences between the groups for glucose, free fatty acids or faecal calprotectin. Within the obese group insulin, low-density lipoprotein cholesterol, and CRP were positively associated with body mass index (BMI) Z-scores. The MS was present in 14% of obese adolescents. CRP was positively associated with most anthropometric measures within the obese group, and in multiple linear regression analysis both BMI Z-score and the sum of skin folds explained a considerable part (R(2) = 0.421) of the variation in CRP.

CONCLUSION:

Otherwise healthy Danish obese adolescents had marked low-grade inflammation, elevated biomarkers of the MS and high prevalence of the MS.

• Authors: Rikke Juul Gøbel, Signe Marie Jensen, Hanne Frøkiaer, Christian Mølgaard, Kim Fleischer Michaelsen
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 101 Issue 2 Pg. 192-200 (Feb 2012) ISSN: 1651-2227 [Electronic] Norway
• PMID: 21995457 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

Chemical References

• Biomarkers
• C-Reactive Protein

Topics

• Adolescent
• Anthropometry
• Biomarkers (blood)
• Blood Pressure
• C-Reactive Protein (analysis)
• Case-Control Studies
• Child
• Denmark (epidemiology)
• Female
• Humans
• Inflammation (blood)
• Male
• Metabolic Syndrome (blood, epidemiology)
• Obesity (blood, complications, physiopathology)
• Risk Factors