Interleukin-6 (Interleukin 6)

17008  relevant articles (392 outcomes, 2123 trials/studies) found for this Bio-Agent

Interleukin 6; IL6; B Cell Stimulatory Factor-2; B-Cell Differentiation Factor; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor 2; B-Cell Stimulatory Factor-2; BSF-2; Differentiation Factor, B-Cell; Differentiation Factor-2, B-Cell; IFN-beta 2; B Cell Differentiation Factor; B Cell Differentiation Factor 2; B Cell Stimulatory Factor 2; Differentiation Factor 2, B Cell; Differentiation Factor, B Cell; Differentiation-Inducing Protein, Myeloid; Growth Factor, Hybridoma; Growth Factor, Plasmacytoma; Hepatocyte Stimulating Factor; Myeloid Differentiation Inducing Protein; Hepatocyte-Stimulating Factor; Hybridoma Growth Factor; IL-6; MGI-2; Myeloid Differentiation-Inducing Protein; Plasmacytoma Growth Factor

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rose-John, Stefan: 14 articles (07/2008 - 05/2002)
2.	Jones, Simon A: 11 articles (08/2008 - 08/2003)
3.	Nishimoto, Norihiro: 10 articles (09/2007 - 09/2002)
4.	Kishimoto, T: 10 articles (09/2006 - 01/2000)
5.	Humphries, S E: 10 articles (08/2006 - 02/2000)
6.	Culig, Zoran: 9 articles (04/2008 - 11/2002)
7.	Lip, Gregory Y H: 9 articles (08/2006 - 07/2003)
8.	Kishimoto, Tadamitsu: 8 articles (07/2008 - 02/2002)
9.	Kuo, Min-Liang: 8 articles (06/2007 - 11/2002)
10.	Rose-John, S: 8 articles (09/2006 - 05/2000)

Related Diseases

1.	Inflammation 11/19/1999 - "The bioactivity of interleukin-6 (IL-6) was found to be dramatically reduced in fluids from sites of inflammation. " 06/01/2007 - "Increased vascular inflammation, including enhanced expression of interleukin- 6 (IL-6), vascular cellular adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein (MCP- 1) are observed, as is a marked decrease in NO bioavailability. " 09/15/2007 - "In vivo studies in a murine inflammation model showed that neutrophil depletion resulted in reduced local sIL6R levels and a concomitant decrease in mononuclear cells, suggesting that apoptosis-induced IL6R shedding from neutrophils promotes IL6 trans-signaling and regulates the attraction of monocytic cells involved in the clearance of apoptotic neutrophils." 09/01/2008 - "The mechanism is possibly related with the improvement in the IL-6 level and hemodynamic indexes, which may promote the subsidence of inflammation of the nerve roots." 01/01/2005 - "Clinical improvement in these children was observed for up to eight weeks, supporting the hypothesis that IL-6 is a key cytokine in the upregulation of genes crucial in the inflammation processes of sJIA, and the possibility of sequestration of MRA in the extra-vascular compartment needs to be considered." Order ALL the reference details at left...
2.	Neoplasms (Cancer) 05/01/1994 - "In cancer patients, increased IL-6 serum levels were related to the presence of the tumor since all post-operative patients exhibited a marked decrease. " 11/01/2007 - "Therapeutic targeting of IL-6 and its receptor in cancer has strong biologic rationale, and there is preliminary evidence suggesting that targeting of the IL-6 system may be beneficial in the treatment of cancer." 08/01/2005 - "Thus, therapeutic strategies aimed at inhibiting the production, expression or action of IL-6 would be quite beneficial in the treatment of cancer. " 06/01/2007 - "The levels of IL-6 and phosphorylated Stat3 were elevated 12 h after the tumor exosome stimulation of murine myeloid precursors, and tumor exosomes were less effective in inhibiting differentiation of BM cells isolated from IL-6 knockout mice. " 09/01/1990 - "Tumors arising in antibody-treated mice retained their IL-6 dependence in vitro, suggesting that the level of protection could be improved if stronger IL-6 antagonists were available." Order ALL the reference details at left...
3.	Infection 05/01/2008 - "There was a statistically significant decline in IL-6 levels both before and during FMF attacks, following eradication therapy in patients who cleared the infection (p < 0.05). " 06/01/2000 - "Development of improved polymerase chain reaction-based clinical methods to detect intra-amniotic infection is necessary to better understand the relationship between elevated AF IL-6, intra-amniotic infection, and preterm delivery." 03/15/1997 - "The finding that UV-inactivated virus was effective in triggering IL-6 production by mouse alveolar macrophages is similar to that reported in human alveolar macrophages, providing further validation of the BALB/c mouse as a useful animal model for human RSV infection." 10/01/2008 - "Interleukin-6 (IL-6) is associated with clearance of herpes simplex virus (HSV) infections and in virus-induced immunopathology. " 01/01/2003 - "Calculation of the differences between preoperative and postoperative levels of IL-6 and CRP was not helpful for early detection of postoperative infections. " Order ALL the reference details at left...
4.	Necrosis 05/15/2008 - "Studies on the cross-talk between pro-inflammatory mediators (IL-1, tumour necrosis factor, lipopolysaccharide) and IL-6 elucidated further regulatory mechanisms. " 08/01/2007 - "Our recent studies have shown that, upon stimulation, IkappaB-zeta is essential for the induction of a subset of inflammatory genes, represented by IL-6, whereas it inhibits the expression of TNF (tumour necrosis factor)-alpha. " 01/07/2001 - "The present study explored the changes in hepatic secretion of tumour necrosis factor (TNF) and interleukin 6 (IL-6) during the regenerative process of the liver, focusing on the role of Kupffer cells. " 06/24/2000 - "In the present study we show that in rats with critically low (10%) hepatocyte mass, whether with or without ongoing liver cell necrosis, inhibition of liver regeneration is associated with early and sustained increase in blood IL-6 levels. " 04/01/1995 - "Our studies indicate that smokers have a compromised antioxidant status and elevated concentrations of tumour necrosis factor and interleukin-6 as a consequence of smoking. " Order ALL the reference details at left...
5.	Sepsis (Septicemia) 01/01/2003 - "These data suggest that IL-6 plays an important role in the increased expression of C5aR in lung, liver, kidney, and heart during the development of sepsis in mice and that interception of IL-6 leads to reduced expression of C5aR and improved survival." 11/01/2006 - "CONCLUSION: Xuebijing injection possesses the protective effects on the kidney in rats with sepsis, which may be related with the synthesis and release of IL-6." 01/01/2003 - "Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression." 08/01/2008 - "CONCLUSION: PCT and IL-6 appear to be helpful in early assessment of pediatric sepsis, are of diagnostic value at admission, and are related to disease severity." 04/01/1992 - "Protection against lethal pneumococcal septicemia in pigs is associated with decreased levels of interleukin-6 in blood." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Cytokines
3.	Interleukin-8 (Interleukin 8)
4.	Interleukin-10 (Interleukin 10)
5.	C-Reactive Protein
6.	Interleukin-1beta (Interleukin 1 beta)
7.	Interleukin-2 (IL2)
8.	Interleukin-1 (Interleukin 1)
9.	Interleukins
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunotherapy
3.	Resuscitation
4.	Tocolysis
5.	Aftercare (After-Treatment)