Metabolic syndrome X: an inflammatory condition?

Abstract

Obesity, atherosclerosis, insulin resistance and hyperinsulinemia, hyperlipidemia, essential hypertension, type 2 diabetes mellitus, and coronary heart disease (CHD) are the components of metabolic syndrome X and are associated with elevated plasma levels of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha, which are markers of inflammation. This suggests that metabolic syndrome X is a low-grade, systemic, inflammatory condition. Hence, instituting anti-inflammatory measures might be beneficial in preventing or halting the progress of metabolic syndrome X in high-risk populations.

• Authors: Undurti N Das
• Journal: Current hypertension reports (Curr Hypertens Rep) Vol. 6 Issue 1 Pg. 66-73 (Feb 2004) ISSN: 1522-6417 [Print] United States
• PMID: 14972097 (Publication Type: Journal Article, Review)

Chemical References

• 11-beta-Hydroxysteroid Dehydrogenase Type 1

Topics

• 11-beta-Hydroxysteroid Dehydrogenase Type 1 (metabolism)
• Adipose Tissue (metabolism, pathology)
• Diabetes Mellitus (metabolism, pathology)
• Diabetes Mellitus, Type 2 (metabolism, pathology)
• Humans
• Inflammation (metabolism, pathology)
• Insulin Resistance (physiology)
• Metabolic Syndrome (metabolism, pathology)
• Obesity
• Prevalence
• United States (epidemiology)