Hyperinsulinism (Hyperinsulinemia)

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5888 relevant articles (229 outcomes, 523 trials/studies) found for this Disease

Description: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.

Also Known As:

Hyperinsulinemia; Compensatory Hyperinsulinemia; Endogenous Hyperinsulinism; Exogenous Hyperinsulinism; Hyperinsulinemia, Compensatory; Hyperinsulinism, Endogenous; Hyperinsulinism, Exogenous

Relationship Network

Disease Context: Research Results

Nutritional and Metabolic Diseases

Metabolic Diseases: 1406

Glucose Metabolism Disorders: 41

Hyperinsulinism: 5888

Insulin Resistance: 21020

Persistent Hyperinsulinemia Hypoglycemia of Infancy: 99

Related Diseases

1.	Hyperglycemia
2.	Insulin Resistance
3.	Hypertriglyceridemia
4.	Obesity
5.	Body Weight (Weight, Body)

Experts

1.	Stanley, Charles A: 6 articles (02/2008 - 04/2004)
2.	Tsuda, Kazushi: 5 articles (11/2006 - 01/2003)
3.	Hussain, Khalid: 5 articles (08/2006 - 11/2002)
4.	Ibáñez, L: 4 articles (12/2001 - 01/2000)
5.	Potau, N: 4 articles (12/2001 - 01/2000)
6.	Draznin, B: 4 articles (08/2001 - 04/2000)
7.	Boden, Guenther: 3 articles (09/2008 - 01/2006)
8.	Arslanian, Silva A: 3 articles (07/2008 - 10/2002)
9.	Spranger, J: 3 articles (06/2008 - 12/2002)
10.	Otto, B: 3 articles (06/2008 - 12/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperinsulinism:

1.	Insulin (Novolin)FDA Link 01/01/1993 - "However, in the majority of the IGT subjects a marked decrease in the early insulin response and a fasting hyperinsulinemia were found. " 07/01/1997 - "The basal GMI did not differ among the three groups in any tissue except tibialis anterior; during hyperinsulinemia, GMI was significantly greater in the insulin-sensitive tissues of all three groups. " 12/01/1996 - "Upon further investigation, we found that insulin secretion in the OLETF-BH rats was decreased to a significant extent, signaling that the hyperinsulinemia typical to the OLETF-BH rats had clearly improved. " 03/01/1992 - "One of the reasons of hyperinsulinemia in PJD in parallel with high insulin secretory pancreatic function can be a decrease in the metabolic clearance of liver insulin, especially noticeable in patients with hepatocyte dysfunction." 05/01/1993 - "These results provide evidence that regular exercise is effective in reducing hyperinsulinemia and improving insulin action in 65-yr-olds to levels typical of young people." Order ALL the reference details at left...
2.	Glucose (Dextrose)FDA LinkGeneric 04/01/1993 - "Hyperinsulinemia, in association with NA infusion (NA study) brings about a significantly greater stimulation of total glucose disposal in both pregnant (approximately 30%) and nonpregnant (approximately 35%) rabbits compared with the control study. " 04/01/1993 - "After hyperinsulinemia, glucose production was normally suppressed, whereas overall glucose utilization was not significantly improved.(ABSTRACT TRUNCATED AT 250 WORDS)" 04/01/1991 - "Overall glucose utilization in the diabetics was significantly higher in the basal state and, after submaximal or maximal hyperinsulinemia, it remained significantly greater (P less than 0.001) than the corresponding utilization in the controls. " 12/01/2006 - "Experiments in p27-deficient mice showed improved glucose tolerance and hyperinsulinemia. " 05/01/2007 - "Previous studies have shown that hyperinsulinemia in HC rats involves a programmed hyperresponsiveness to glucose. " Order ALL the reference details at left...
3.	Metformin (Glucophage)FDA LinkGeneric 11/01/2005 - "RESULTS: Significant effect of metformin therapy was observed at 3 months follow-up visit, 5 (16.7%) women achieved pregnancy while 20 (66.6%) women had a regular menstrual cycle (p = 0.001), and a significant reduction in weight (67.4 vs. 65.4, p = 0.001) and hyperinsulinemia (FBS: FI = 3.34 vs. 6.63, p = 0.001) was noted. " 07/01/2006 - "CONCLUSION: In women with PCOS treatment with metformin is effective in the lowering of hyperinsulinemia and hyperandrogenemia. " 09/01/2000 - "It is concluded that metformin, probably by way of its effect on adipose tissue, leads to reduction of hyperinsulinemia and concomitant improvement in the menstrual pattern; and therefore, it offers a useful alternative treatment for obese, anovulatory women with PCOS. " 07/01/2008 - "In a second clinical trial and in several case reports, AN and hyperinsulinemia did show improvement with metformin treatment. " 01/01/2001 - "CONCLUSION: Hyperinsulinemia and androgen excess in obese non-diabetic women with PCOS are not improved by the administration of metformin. " Order ALL the reference details at left...
4.	troglitazone (Rezulin)FDA Link 03/01/1995 - "The present study was performed to evaluate whether the amelioration of hyperinsulinemia by troglitazone lowers blood pressure in essential hypertensives. " 09/01/1997 - "The effects of troglitazone, administered as a food admixture (24 mg/day) for 6 months, on hyperinsulinemia and BP were examined in WHHL rabbits. " 05/01/2002 - "These results suggest that the beneficial effects of troglitazone in PCOS may not be due solely to improvement of peripheral insulin resistance and hyperinsulinemia, but also to a possible direct effect on ovarian steroidogenesis." 05/01/1999 - "CONCLUSION(S): Troglitazone treatment resulted in attenuation of both hyperinsulinemia and hyperandrogenism in an obese woman with HAIR-AN and resulted in resumption of menses and a spontaneous pregnancy." 03/15/1998 - "Administration of troglitazone for 15 d normalized mild hyperglycemia and marked hyperinsulinemia in these rats. " Order ALL the reference details at left...
5.	FructoseIBA 06/01/2008 - "Compared with control diet, fructose feeding induced hyperinsulinemia, HOMA-IR and increased triglyceride (all P<0.01). " 06/30/2007 - "The increase in GIR was lower in fructose-fed groups than in control groups under similar hyperinsulinemia. " 04/01/2006 - "Hyperinsulinemia is triggered by dietary fructose, which sensitizes blood pressure for salt intake. " 10/25/2005 - "The results obtained are as follows: (1) 17beta-E(2) protected against the effect of high fructose diet, which caused an increase in SBP, hyperinsulinemia and a decrease in ISI in ovariectomized rats. " 01/01/2003 - "In conclusion, improvement of hyperinsulinemia can decrease NHE activity and blood pressure in fructose-fed BHR." Order ALL the reference details at left...
6.	HormonesIBA 05/01/1994 - "Hyperinsulinemia and hyperglucagonemia may be caused either by increased beta- and alpha-cell secretion or by defective hepatic clearance of these hormones. " 01/01/1975 - "Institution of a calorie restricted diet (nine patients) which ameliorated the hyperinsulinemia, produced an improvement in hormone binding. " 08/01/2006 - "CONCLUSION(S): Variation in ovarian hormones associated with the menstrual cycle or short-term ovarian hormone deficiency induced by GnRHa do not affect calf blood flow under postabsorptive conditions or the response to hyperinsulinemia." 12/01/2004 - "In addition, hyperinsulinemia (P = 0.01) with hypocorticosteronemia (P = 0.007) occurred during the postnatal period with hypercorticosteronemia (P = 0.007) and hypoleptinemia (P = 0.008) and an increase in leutinizing hormone (P = 0.01) in the adult male and female progeny. " 10/01/1999 - "Peripheral hyperinsulinemia derives from the combination of normal hepatic extraction with an overproduction of hormone, mostly due to the basal component. " Order ALL the reference details at left...
7.	Blood Glucose (Blood Sugar)IBA 01/01/2005 - "In contrast, unilateral reactivation markedly improved hyperinsulinemia and normalized blood glucose levels and locomotor activity. " 04/01/2009 - "In this model, we now investigated the impact of blood glucose lowering vs. hyperinsulinemia (HI) on mitochondria in relation to organ damage. " 10/01/2004 - "Blood glucose control during selective arterial stimulation and venous sampling for localization of focal hyperinsulinism lesions in anesthetized children." 11/01/2002 - "Hyperinsulinemia (85.0 +/- 33.2 at baseline vs. 482.8 +/- 64.4 pmol/l during steady state; p < 0.01) was achieved using a euglycemic hyperinsulinemic clamp, keeping blood glucose levels basically unchanged during the intervention (4.6 +/- 0.14 vs. 4.37 +/- 0.15 mmol/l, respectively; ns). " 08/01/1998 - "We conclude that after parturition the offspring is no longer exposed to the high blood sugar levels found in both diabetic groups of mothers, thereby no hyperinsulinemia is needed; as time elapses, then, the area of their Langerhans islets tends to normalization." Order ALL the reference details at left...
8.	Diazoxide (Hyperstat)FDA Link 08/01/1998 - "We reviewed 77 cases of primary persistent hyperinsulinism in neonates and infants who were treated with diazoxide and studied criteria predictive of therapeutic efficacy. " 01/01/2008 - "Linear regression assay demonstrated a close correlation between decreasing hyperinsulinemia and the protective effects of diazoxide. " 08/01/2007 - "We describe a one month-old infant who was treated with diazoxide for prolonged neonatal hyperinsulinism. " 08/01/2007 - "Diazoxide is commonly used in the treatment of neonatal hyperinsulinism. " 06/01/2005 - "Ketotic hypoglycaemia in children with diazoxide responsive hyperinsulinism of infancy." Order ALL the reference details at left...
9.	LeptinIBA 04/01/2004 - "The aim of this study was to investigate whether the situation persists at the 2nd postnatal day, taking the fasting and satiety states into account and the influence of fetal exposure to hyperinsulinemia, which are proven important contributing factors to plasma leptin levels. " 05/15/2000 - "From these studies we conclude that CNS hyperinsulinemia can act to attenuate the leptin-induced increases in sympathetic nervous and cardiovascular system activity. " 04/01/2000 - "This study was initiated to evaluate the role of hyperinsulinemia in the regulation of fasting plasma leptin. " 06/01/1997 - "This paradox may be explained by the presence of adipocyte IR specific to PCOS, which may negate the stimulatory impact of hyperinsulinemia on leptin secretion, a proposition requiring further study." 04/01/1997 - "On the other hand, during the hyperinsulinemic euglycemic clamp studies, hyperinsulinemia acutely increased leptin concentrations (20%) only in women. " Order ALL the reference details at left...
10.	Glucagon (Glukagon)FDA Link 11/01/1992 - "However, the secretion of glucagon was blunted following prolonged hyperinsulinemia, increasing to levels of 249 +/- 17 ng/L in the brief studies and to only 185 +/- 20 ng/L in the prolonged studies (P < 0.005). " 05/01/1988 - "In this study, hyperinsulinemia led to a decrease in the plasma glucagon concentration. " 04/01/1980 - "These studies demonstrate that glycemic control with AEP is accompanied by hyperinsulinemia, which could account for the amino acid responses and the small alterations in immunoreactive glucagon (IRG) patterns. " 01/01/1980 - "In addition to the hyperinsulinemia previously reported to occur in nonhyperphagic VMH-lesioned rats, this study showed an increased glucagon secretion from perfused pancreases of these animals. " 05/01/2009 - "In addition, unlike increasing the percentage of calories as fat, inappropriate glucagon secretion in the absence of compensatory hyperinsulinemia limits whole body nutrient disposition." Order ALL the reference details at left...

Therapies and Procedures

1.	Pancreatectomy 07/01/1958 - "[Hyperinsulinism due to insulinoblastoma cured by partial pancreatectomy.]" 04/01/2009 - "Although previous reports describe high success rates without pre-operative localization, more recent recognition of the overlap among causes of endogenous hyperinsulinism, coupled with the deleterious long-term effects of blind distal pancreatectomy and re-operation, mandate the need for precise pre-operative localization or regionalization of the tumour(s). " 12/01/2007 - "While focal hyperinsulinism may be reversed by selective surgical resection, diffuse forms require near-total pancreatectomy when resistant to medical treatment. " 01/01/2007 - "Regeneration after near-total pancreatectomy was documented in 4 patients, with aggregates of endocrine tissue observed at subsequent operations in 3. Although the absence of enlarged islet cell nuclei is a useful discriminant of focal hyperinsulinism associated with a paternal ABCC8 mutation, further research is needed to understand the pathophysiology of other histological abnormalities in patients with HI, which may have implications for mechanisms of ductal and islet cell proliferation. " 01/01/2006 - "In order to evaluate whether all cases of focal hyperinsulinism are caused by this mechanism, 56 pancreatectomy specimens with focal hyperinsulinism were tested for the loss of maternal allele by two methods: immunohistochemistry for p57(kip2) (n=56) and microsatellite marker analysis (n=27). " Order ALL the reference details at left...
2.	Oral Administration 03/23/2001 - "Oral administration of all liposomal species resulted in hyperinsulinemia. " 01/01/2000 - "Hyperinsulinemia in Zucker fatty rats was reduced by 23%, 26%, 60% and 50%, respectively, 3, 4, 6 and 8 weeks after starting the oral administration of WSSP. " 01/01/1999 - "Hyperinsulinemia was reduced dose-dependently in yellow KK mice by 1%, 24%, 34%, and 66% after the fifth oral administration of 0.3, 1, 3, and 10 mg/kg/d. " 05/23/1996 - "In fa/fa rats oral administration of M16209 (30 and 100 mg/kg/day) for 7 days dose dependently improved hyperinsulinemia without affecting body weight. " 06/01/2006 - "Although previous studies addressed the effects of hyperglycemia in conditions of hyperinsulinemia, it has not been evaluated whether the route of glucose administration (oral vs. intravenous) plays a role. " Order ALL the reference details at left...
3.	Caloric Restriction 02/15/2009 - "Caloric restriction in Alström syndrome prevents hyperinsulinemia." 02/01/1996 - "The combined findings of old age, obesity, hyperinsulinemia, improvement in response to caloric restriction, and islet amyloidosis are consistent with type 2 diabetes mellitus." 05/01/2004 - "Moreover, the patients had very high fasting serum free fatty acid (FFA) levels (2150 and 1919 micromol/L, respectively), which proved to be sensitive to inhibition by oral glucose tolerance test (OGTT)-induced hyperinsulinemia as well as to caloric restriction. " 02/01/1995 - "CONCLUSION: We conclude that growth hormone exerts anabolic effects that attenuate over time during caloric restriction but maintains its lipolytic effect despite hyperinsulinism and results in accelerated fat loss." 06/11/2004 - "Continuous intracerebroventricular leptin infusion or caloric restriction yielded Irs2(-/-) mice whose adiposity was comparable to that of Irs2(+/+) mice, and both the hyperglycemia and the hyperinsulinemia of these mice improved with increased Rd albeit partially. " Order ALL the reference details at left...
4.	Transplantation (Transplant Recipients) 05/01/1994 - "During combined hyperinsulinemia and hyperaminoacidemia (study 2), IDDUP showed a defective stimulation of NOLD (27.9 +/- 0.7 vs. 36.1 +/- 0.8 mumol.m-2.min-1, P < 0.01 compared to CON), which was normalized by transplantation (44.3 +/- 0.8 mumol.m-2.min-1)." 05/01/2006 - "OBJECTIVE: To establish an porcine model of whole pancreaticoduodenal transplantation with portal venous drainage and enteric drainage for ensuring physiologically normal function without hyperinsulinemia and reducing postoperative complications. " 01/01/2005 - "FAS overexpression can be attributed to the local hyperinsulinemia in the transplantation model and belongs to cellular and metabolic alterations in the chemical model, which are induced by an insulinomimetic but yet unknown mechanism." 10/01/1996 - "However, this is compensated by a normal SG and by hyperinsulinemia to maintain euglycemia; 3) SI improves by 12 months and normalizes from 24-48 months, after transplantation, despite hyperinsulinemia and long-term immunosuppressive therapy. " 10/01/1993 - "Hyperinsulinemia after pancreatic transplantation. " Order ALL the reference details at left...
5.	Transplants (Transplant) 10/01/2000 - "A significant peripheral hyperinsulinemia, however, is found when the pancreas graft is connected to the systemic venous circulation. " 03/01/1996 - "During hyperinsulinemia, pancreas-transplant patients show a normal inhibition of FFA turnover and FFA oxidation. " 01/01/1996 - "Only the patients with SPK transplants presented late hyperinsulinemia at 120 minutes. " 01/01/1989 - "A marked hyperinsulinemia after meals was observed in whole-organ graft recipients. " 02/01/1997 - "Successful pancreas transplantation leads to hyperinsulinemia and normoglycemia, in contrast to hypoinsulinemia and hyperglycemia in the patients who receive kidney transplants alone. " Order ALL the reference details at left...

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