Chronic Cough

Cough lasting for greater than 8 weeks in adults potentially impacting HEALTH-RELATED QUALITY OF LIFE. Chronic cough generally is associated with eosinophilic airway inflammation (e.g., asthma (COUGH-VARIANT ASTHMA) and non-asthmatic BRONCHITIS, upper airway disorders, GERD and cough hypersensitivity syndrome).

Also Known As:

Networked: 1422 relevant articles (134 outcomes, 238 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cough
2.	Gastroesophageal Reflux (GERD)
3.	Asthma (Bronchial Asthma)
4.	Bronchitis
5.	Inflammation (Inflammations)

Experts

1.	Birring, Surinder S: 33 articles (01/2022 - 01/2004)
2.	Morice, Alyn H: 28 articles (01/2022 - 10/2002)
3.	Smith, Jaclyn A: 26 articles (01/2022 - 06/2007)
4.	Chung, Kian Fan: 18 articles (01/2022 - 10/2005)
5.	Irwin, Richard S: 18 articles (01/2022 - 01/2002)
6.	Yu, Li: 17 articles (01/2021 - 05/2008)
7.	Niimi, Akio: 16 articles (10/2022 - 12/2004)
8.	Qiu, Zhongmin: 16 articles (01/2021 - 05/2008)
9.	Chang, Anne B: 15 articles (01/2022 - 01/2006)
10.	Song, Woo-Jung: 13 articles (01/2022 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Cough:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 11/24/2021 - "UACS may be the most common cause of chronic cough in Japan and may be effectively treated with nasal corticosteroids. " 05/01/2012 - "The efficacy of an inhaled corticosteroid plus β2-agonist against the persistent cough after pulmonary resection was evaluated in this study. " 10/31/2023 - "FeNO measurement may help to identify patients with chronic cough that will benefit from corticosteroid treatment. " 05/01/2019 - "Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial. " 05/01/2012 - "We enrolled 21 patients in this prospective study of the efficacy of an inhaled corticosteroid plus β2-agonist against persistent cough following pulmonary resection. "
2.	Antitussive Agents (Antitussives)FDA Link 06/01/2008 - "[Lower airway nervous system as a putative target of antitussive drugs effective for treatment of chronic cough]." 12/01/2023 - "Improved understanding of CANVAS may lead to an enhanced grasp of the pathophysiology of chronic cough, and new approaches to antitussive treatments." 01/01/2023 - "Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study." 01/01/2020 - "P2X3-Receptor Antagonists as Potential Antitussives: Summary of Current Clinical Trials in Chronic Cough." 11/09/2023 - "This retrospective observational cohort study considered chronic cough patients aged 18 years and older who were consistently prescribed antitussive agents for more than 2 months between 1 January 2017 and 30 June 2019. "
3.	GefapixantIBA 12/01/2021 - "Gefapixant was generally well tolerated but was not associated with a significant improvement in chronic cough in subjects with IPF as defined by the primary endpoint in this study. " 01/01/2020 - "Gefapixant has previously demonstrated efficacy in the treatment of refractory chronic cough at a high daily dose. " 04/01/2021 - "Safety and efficacy of gefapixant, a novel drug for the treatment of chronic cough: A systematic review and meta-analysis of randomized controlled trials." 01/01/2022 - "Gefapixant 45 mg twice per day is the first treatment to show efficacy with an acceptable safety profile in phase 3 clinical trials for refractory chronic cough or unexplained chronic cough. " 01/01/2020 - "The aim of this study was to evaluate the efficacy of gefapixant compared with placebo after 12 weeks of treatment for refractory chronic cough or unexplained chronic cough. "
4.	Purinergic P2X3 ReceptorsIBA 10/01/2023 - "Focusing on four P2X3 receptor antagonists with proven efficacy in clinical studies, we analyzed the characteristics and disadvantages of each drug by comparing their clinical results of them and theoretically explained the common side effects of these drugs, as well as their potential for treating refractory chronic cough. " 10/01/2023 - "KEY MESSAGE: There were plenty of studies about P2X3 receptor antagonists in the past, and in recent years this series of drugs are effective in refractory chronic cough. " 09/09/2023 - "Safety and efficacy of P2X3 receptor antagonist for the treatment of refractory or unexplained chronic cough: A systematic review and meta-analysis of 11 randomized controlled trials." 09/09/2023 - "We conducted this systematic review and meta-analysis to determine the long-term safety and efficacy of P2X3 receptor antagonist drugs in chronic cough. " 10/01/2023 - "Recently, several studies have identified P2X3 receptor antagonists for the treatment of refractory chronic cough, and this paper reviews the background, mechanism of action, evidence-based proof and application prospects of this class of drugs. "
5.	Gabapentin (Neurontin)FDA LinkGeneric 07/01/2018 - "Gabapentin treatment of patients with chronic cough showed superior efficacy and a good safety record compared with placebo or standard medications. " 11/03/2012 - "We established the efficacy of gabapentin in patients with refractory chronic cough. " 11/03/2012 - "Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial." 07/01/2018 - "The present systematic review was designed to assess the evidence for efficacy and safety of gabapentin in the treatment of chronic cough. " 07/01/2018 - "Efficacy and Safety of Gabapentin in the Treatment of Chronic Cough: A Systematic Review."
6.	Anti-Bacterial Agents (Antibiotics)IBA 09/01/2022 - "Misdiagnosis and inappropriate treatment are prevalent in patients with chronic cough and lead to considerable antibiotic abuse. " 01/01/2019 - "A 7-month-old Cavalier King Charles Spaniel female was referred due to a chronic cough refractory to antibiotic treatments. " 01/01/2017 - "A 44 year old Hispanic male presented to a pulmonologist's office after failing multiple courses of antibiotics for chronic cough, now six months in duration. " 09/01/2014 - "We report the observation of a 71-year-old woman with chronic cough and persisting alveolar opacities after several courses of antibiotics. " 12/15/1998 - " Initial empiric antibiotic coverage in this setting should target pneumococcus and gram-negative enteric bacilli, while patients presenting with chronic cough should be evaluated for TB."
7.	BaclofenFDA LinkGeneric 01/01/2021 - "Therapeutic efficacy of baclofen is suboptimal in the treatment of refractory gastroesophageal reflux-induced chronic cough (GERC). " 01/01/2021 - "Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough." 07/21/2013 - "Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough." 10/18/2012 - "Here, we summarized the experience of successful resolution of refractory chronic cough due to gastroesophageal reflux with baclofen in three patients. " 10/18/2012 - "Successful resolution of refractory chronic cough induced by gastroesophageal reflux with treatment of baclofen."
8.	AcidsIBA 06/01/2007 - "For chronic cough, studies are all small and have not demonstrated consistent improvement with acid suppression. " 12/01/1992 - "We conclude that patients with chronic persistent cough have impaired clearance of esophageal acid." 12/01/1992 - "Chronic persistent cough and clearance of esophageal acid." 03/01/2023 - "The most common reported respiratory manifestation of non-acid reflux in children was chronic cough (7 studies). " 05/01/2011 - "The aim of this study was to explore the pathogenesis of chronic cough caused by non-acid reflux. "
9.	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/01/2007 - "Forty-one patients had elevated exhaled nitric oxide levels (defined as >or=35 ppb), 36 (88%) of whom had significant improvement in their chronic cough (likelihood ratio of a positive response, 4.9; 95% confidence interval, 2.2-10.9). " 11/01/2008 - "This study aimed to evaluate the role of exhaled nitric oxide (NO) for the investigation of chronic cough, especially of NAEB. " 10/31/2023 - "Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review." 10/20/2022 - "To investigate the impact of a history of atopy on the value of fractional exhaled nitric oxide (FENO) for predicting sputum eosinophils in patients with chronic cough. " 01/01/2021 - "To evaluate the contribution of fractional exhaled nitric oxide (FeNO) and impulse oscillometry (IOS) and spirometric parameters in predicting bronchial hyperresponsiveness (BHR) in adults with chronic cough. "
10.	Codeine (Codeine Phosphate)FDA LinkGeneric 07/13/2016 - "To evaluate the safety and efficacy of codeine (and derivatives) in the treatment of chronic cough in children. " 07/13/2016 - "This review has highlighted the absence of any randomised controlled trials evaluating codeine-based medications in the treatment of childhood chronic cough. " 07/13/2016 - "We considered studies eligible for analysis when: the participant population included children aged less than 18 years with chronic cough (duration equal to or more than four weeks at the time of intervention); and the study design evaluated codeine or codeine-based derivatives against placebo through a randomised controlled trial. " 06/01/2023 - "Codeine-based preparations are to be considered as a last resort in patients with an unexplained chronic cough when other treatments have failed. " 04/28/2023 - "Codeine prescription may be frequent and chronic in real-world practice of patients with chronic cough, despite the lack of robust clinical evidence on the efficacy. "

Therapies and Procedures

1.	Therapeutics 06/01/2009 - "After 5 months of therapy, the patient's chronic cough resolved completely, sputum cultures became negative for Myobacterium avium-intracellulare and the CD4(+) T cell count increased to 553 cells/mm(3). " 07/11/2013 - "Significant improvement of LCQ scores occurred with CPAP therapy for OSA in chronic cough patients. " 10/01/2007 - "There was a significant improvement of the chronic cough of 75.4 per cent (98/130) of patients after successful H pylori eradication using appropriate medical therapy (p<0.001). " 01/01/2018 - "A better understanding of how these sources of heterogeneity are expressed across individual patients with chronic cough is needed to better predict the efficacy of clinical management strategies and of specifically targeted therapies, which will facilitate the development of more personalised clinical approaches to treat patients with chronic cough." 03/01/1992 - "This case emphasizes that specific therapy based upon an accurate diagnosis almost always results in effective treatment of chronic cough."
2.	Fundoplication 12/28/2021 - "Long-Term Outcomes of Chronic Cough Reduction after Laparoscopic Nissen Fundoplication-A Single-Center Study." 07/19/2012 - "There is a paucity of data regarding response to fundoplication in patients presenting with chronic cough. " 08/01/2006 - "To evaluate the frequency of chronic cough associated with nonacid reflux and the response of these patients to laparoscopic Nissen fundoplication. " 10/01/2005 - "We found laparoscopic fundoplication to be objectively beneficial in GERD-induced chronic cough, as it reduced the CACT." 01/01/2014 - "Laparoscopic Nissen fundoplication is more effective in treating patients with GERD-related chronic cough than Stretta radiofrequency."
3.	Speech Therapy (Therapy, Speech) 12/30/2018 - "The aim of the study was to implement speech therapy and assess its efficacy in the management of patients with difficult-to-treat chronic cough. " 01/01/2017 - "The results of recent studies suggest that speech therapy (speech language intervention) is one of the few methods which are usefull in management of persistent chronic cough. " 12/30/2018 - "Speech therapy is one of the few therapeutic methods which seems to be useful in patients with persistent chronic cough. " 12/30/2018 - "Speech therapy in the management of difficult-to-treat chronic cough - preliminary results." 01/01/2017 - "Speech therapy - a non-pharmacological method to manage difficult-to-treat chronic cough."
4.	Language Therapy (Language Training) 01/01/2017 - "In refractory chronic cough, physiotherapy plus speech and language therapy improved quality of life at 4 weeks." 01/01/2017 - "Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial." 07/23/2019 - "To evaluate the effectiveness of speech and language therapy for treatment of people with unexplained (idiopathic/refractory) chronic cough. " 12/01/2017 - "Physiotherapy and Speech and Language therapy intervention for chronic cough." 01/01/2017 - "Physiotherapy, and speech and language therapy are emerging non-pharmacological treatments for refractory chronic cough. "
5.	Continuous Positive Airway Pressure 01/01/2022 - "This study aimed to explore whether continuous positive airway pressure (CPAP), antireflux treatment and lifestyle modifications improve chronic cough in patients with OSA and concomitant GER. " 11/05/2013 - "The aim of this study was to compare the incidence of chronic cough between patients with and without OSA and the impact of continuous positive airway pressure (CPAP) treatment in resolving chronic cough. " 01/01/2014 - "Utility of continuous positive airway pressure therapy for treating chronic coughs in patients with obstructive sleep apnea." 01/01/2022 - "Effect of Continuous Positive Airway Pressure on Chronic Cough in Patients with Obstructive Sleep Apnea and Concomitant Gastroesophageal Reflux." 01/01/2020 - "An association between chronic cough and obstructive sleep apnea (OSA) has been reported in prior studies with resolution or improvement in cough after continuous positive airway pressure (CPAP) therapy. "