Zinc Finger Protein GLI1

A transcriptional activator and oncogene protein that contains two CYS2-HIS2 ZINC FINGERS. Two isoforms are expressed; both regulate the expression of specific genes during development of craniofacial features, digits, the CENTRAL NERVOUS SYSTEM; and the GASTROINTESTINAL TRACT. They also regulate SONIC HEDGEHOG PROTEIN signaling and cell proliferation.

Also Known As:

Networked: 47 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zheng, Xin: 3 articles (08/2014 - 11/2010)
2.	Li, Jianfang: 2 articles (04/2017 - 01/2014)
3.	Liu, Bingya: 2 articles (04/2017 - 01/2014)
4.	Yu, Beiqin: 2 articles (04/2017 - 01/2014)
5.	Xu, Ling: 2 articles (04/2016 - 04/2011)
6.	Ruppert, J Michael: 2 articles (03/2015 - 06/2006)
7.	Liu, Qingguang: 2 articles (08/2014 - 11/2010)
8.	Tu, Kangsheng: 2 articles (08/2014 - 11/2010)
9.	Yang, Wei: 2 articles (08/2014 - 05/2012)
10.	Yao, Yingmin: 2 articles (08/2014 - 11/2010)

Related Diseases

1.	Neoplasms (Cancer) 11/14/2023 - "Increased GLI1 protein immunoreactivity was observed in KIRC tissues, especially in early-stage tumors, according to the TNM classification. " 05/10/2023 - "MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer." 08/01/2020 - "In this case report, we describe a malignant tumor from the jejunum with a MALAT1-GLI1 gene fusion that expressed a truncated constitutively active GLI1 protein and GLI1 targets that were detectable by immunohistochemistry. " 10/01/2018 - "However, limited published work has investigated the nuclear staining of GLI1 protein in human tumor tissue samples by immunohistochemical analysis. " 01/01/2018 - "Furthermore, for subcutaneous tumor-bearing mice, treatment with the DMP-Gli1si complex significantly inhibited tumor growth by inhibiting Gli1 protein expression, promoting apoptosis, and reducing proliferation. "
2.	Glioma (Gliomas) 02/01/2021 - "Through screening of current clinical BRD4 inhibitors for their inhibitory potency against glioma-associated oncogene homolog (GLI) protein, the BRD4 inhibitor 2 was selected as the lead for further structural optimization, which led to the identification of compounds 25 and 35 as the high potency HH inhibitors. " 04/01/2014 - "In conclusion, microRNA218 could reduce the invasion and migration, and inhibit proliferation of glioma cells by suppressing the expression of GLI1 protein at the interacting with the N terminus. " 01/01/2017 - "In the course of this, LiCl induced inhibitory glycogen synthase kinase-3β (GSK-3β) serine 9 phosphorylation, whereas glioma associated oncogene family 1 (GLI1) protein expression was particularly reduced by combined ATO and LiCl treatment in RD and RH-30 cell lines, showing high rates of apoptotic cell death. " 02/01/2011 - "In this study, we attempted to determine the expression of Bmi-1 stem cell marker and of Shh pathway downstream target genes glioma-associated oncogene homolog 1 (GLI1), protein patched homolog 1 (PTCH1), Cyclin D2, plakoglobin (γ catenin), NK2 homeobox 2 (NKX2.2), paired box gene 6 (PAX6), secreted frizzled-related protein 1 (SFRP1), and hedgehog interacting protein (HHIP) in 11 neuroblastoma cell lines and 41 neuroblastoma samples. "
3.	Carcinoma (Carcinomatosis) 12/01/2012 - "Gli1 protein is a core epithelial-to-mesenchymal transition (EMT) regulatory factor that plays essential roles in both development and disease processes and has been associated with metastasis in carcinomas. " 12/01/2006 - "Smo protein expression in gastric carcinoma was significantly correlated with that of Gli1 protein with correlation coefficient of 0.989 (P<0.001). " 12/01/2006 - "To study the expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma. " 01/01/2015 - "To elucidate the regulation of Gli1 expression, we found that both Gli inhibitor arsenic trioxide and PI3K inhibitor LY294002 significantly reduced Gli1 protein expression and colon carcinoma cell proliferation. " 12/01/2006 - "[Expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma]."
4.	Neuroblastoma 08/01/2013 - "We also demonstrated that AKT2 overexpression regulates the nuclear-cytoplasmic distribution of exogenous Gli1 protein in neuroblastoma cells by relieving a GSK3β-mediated destabilization of SUFU, a negative regulator of Gli1 nuclear translocation. " 02/01/2011 - "In this study, we attempted to determine the expression of Bmi-1 stem cell marker and of Shh pathway downstream target genes glioma-associated oncogene homolog 1 (GLI1), protein patched homolog 1 (PTCH1), Cyclin D2, plakoglobin (γ catenin), NK2 homeobox 2 (NKX2.2), paired box gene 6 (PAX6), secreted frizzled-related protein 1 (SFRP1), and hedgehog interacting protein (HHIP) in 11 neuroblastoma cell lines and 41 neuroblastoma samples. "
5.	Pyogenic Granuloma 01/01/2017 - "The immunohistochemical study established increased proliferative activity of epithelial cells specific both pyogenic granuloma and oral SCC, but intensive Gli1 protein expression in membranes and cytoplasm of epithelial cells with malignant transformation allowed differentiation of these neoplasms. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Transcription Factors (Transcription Factor)
3.	Cyclin D2
4.	gamma Catenin (Plakoglobin)
5.	Catenins
6.	Patched-1 Receptor
7.	WD repeat containing planar cell polarity effector
8.	Messenger RNA (mRNA)
9.	BH3 Interacting Domain Death Agonist Protein
10.	Proteasome Endopeptidase Complex (Proteasome)

Related Therapies and Procedures

1.	Therapeutics