Transcription Factors (Transcription Factor)

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10777 relevant articles (73 outcomes, 690 trials/studies) found for this Bio-Agent

Description: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

Also Known As:

Transcription Factor; Factor, Transcription; Factors, Transcription

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 58433

Transcription Factors: 10777

NF-kappa B: 8561

beta Catenin: 3493

Steroid Receptors: 1476

Calcitriol Receptors: 1196

Peroxisome Proliferator-Activated Receptors: 771

Trans-Activators: 628

Aryl Hydrocarbon Receptors: 492

Retinoic Acid Receptors: 464

Thyroid Hormone Receptors: 310

Sigma Factor: 249

heat shock transcription factor: 243

E2F Transcription Factors: 167

I-kappa B Proteins: 126

Core Binding Factors: 124

BRCA1 Protein: 119

thyroid nuclear factor 1: 79

Smad Proteins: 67

nuclear receptor coactivator 1: 62

NFI Transcription Factors: 55

Notch Receptors: 52

Proto-Oncogene Proteins c-ets: 52

Transcription Factor AP-2: 46

Basic Helix-Loop-Helix Transcription Factors: 44

elongin: 43

Steroidogenic Factor 1: 43

Tristetraprolin: 36

TCF Transcription Factors: 35

Cyclic AMP Receptor Protein: 33

GATA Transcription Factors: 31

Interferon Regulatory Factors: 31

constitutive androstane receptor: 30

Repressor Proteins: 28

mitochondrial transcription factor A: 27

NFATC Transcription Factors: 27

peroxisome-proliferator-activated receptor-gamma coactivator-1: 25

negative elongation factor: 16

steroid receptor coactivator AIB1: 16

Tsg101 protein: 16

Adenovirus E1A Proteins: 14

Basic-Leucine Zipper Transcription Factors: 14

BCL2-associated athanogene 1 protein: 14

Nuclear Receptor Coactivator 2: 13

STAT Transcription Factors: 13

thyroid hormone associated protein complex: 13

Hepatocyte Nuclear Factors: 12

Proto-Oncogene Proteins c-myb: 12

POU Domain Factors: 11

General Transcription Factors: 10

Transcription Factor DP1: 10

transcriptional intermediary factor 1: 9

Leucine-Responsive Regulatory Protein: 8

Proto-Oncogene Proteins c-rel: 8

transcription factor PEA3: 8

APECED protein: 7

regulatory factor X transcription factors: 7

NBPhox protein: 6

transcription factor MTF-1: 6

Rho Factor: 5

Adenovirus E1B Proteins: 4

Interferon-Stimulated Gene Factor 3: 4

Paired Box Transcription Factors: 4

rice nuclear protein GT-2: 4

snail family transcription factors: 4

enhancer-binding protein AP-4: 3

EWS-FLI fusion protein: 3

Myeloid-Lymphoid Leukemia Protein: 3

nocturnin: 3

Nuclear Respiratory Factors: 3

Winged-Helix Transcription Factors: 3

1 T-lymphocyte regulatory protein: 2

Antennapedia Homeodomain Protein: 2

human HIRA protein: 2

Kruppel-Like Transcription Factors: 2

LIM homeobox transcription factor 1 beta: 2

thyroid-hormone-receptor interacting protein: 2

DMRT1 protein: 1

Early Growth Response Transcription Factors: 1

enhancer-binding protein NF-E4: 1

farnesoid X-activated receptor: 1

fetoprotein transcription factor: 1

homeobox protein PITX3: 1

Host Cell Factor C1: 1

human PML protein: 1

human TFB1M protein: 1

Immunoglobulin J Recombination Signal Sequence-Binding Protein: 1

MSX1 Transcription Factor: 1

Nuclear Factor 90 Proteins: 1

sigma K: 1

transcription factor BTF3: 1

Transcriptional Elongation Factors: 1

zebrafish LEF1 protein: 1

Acinetobacter BenM protein

Acinetobacter catM protein

Acremonium chrysogenum CPCR1 protein

Acremonium chrysogenum FKH1 protein

Actinobacillus pleuropneumoniae HlyX protein

activator of CREM in testis (ACT)

adenovirus MLTF protein

Aedes aegypti REL1 protein

Aeromonas salmonicida ASAR protein

Experts

1.	Yamamoto, Masayuki: 8 articles (07/2008 - 05/2002)
2.	Harris, Adrian L: 6 articles (10/2008 - 10/2003)
3.	Banham, Alison H: 6 articles (10/2008 - 05/2004)
4.	Dorfman, David M: 6 articles (02/2007 - 05/2003)
5.	Aggarwal, Bharat B: 6 articles (02/2006 - 02/2003)
6.	Ray, Alpana: 5 articles (01/2008 - 01/2002)
7.	Ray, Bimal K: 5 articles (01/2008 - 01/2002)
8.	Costa, Robert H: 5 articles (04/2007 - 06/2002)
9.	Glimcher, Laurie H: 5 articles (02/2007 - 12/2003)
10.	Latchman, D S: 5 articles (01/2006 - 07/2001)

Related Diseases

1.	Neoplasms (Cancer) 05/28/2001 - "This approach is now rendered possible by major advances along several lines of investigation: (i) the possibility of analysing gene expression through high throughput methods; (ii) a more detailed knowledge of the regulatory regions and of the transcription factors that control gene expression also facilitated in the future by a comprehensive whole genome comparative analysis of these regulatory sequences; (iii) the ability of modulating gene expression at the single gene level through various approaches both pharmacological and biochemical; (iv) the opportunity of directly antagonizing the aberrant activities of oncogenic transcription factors through a detailed knowledge of their abnormal transcriptional function; (v) the possibility of validating, in vivo, in animal models the relevance for neoplastic transformation of specific transcriptional events as well as of testing the efficacy of 'transcription therapy' in faithful animal models of human cancer. " 06/15/2004 - "Improved understanding of how transcription factors affect cancer biology may lead to improved ability to predict clinical outcome and discovery of novel therapeutic strategies. " 10/01/2009 - "Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers." 02/03/2005 - "In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy." 11/01/2009 - "Previous studies implicate upregulation of the oncogenic nuclear transcription factor c-Myc with aggressive behavior of many solid tumors. " Order ALL the reference details at left...
2.	Inflammation 06/01/2008 - "RECENT FINDINGS: The impact of the T regulatory cells, characterized by the expression of CD25 and the foxp3 transcription factor, on the development and remission from central nervous system inflammation, and their therapeutic potential, is being aggressively studied in preclinical animal models. " 06/01/2008 - "In both models of intestinal inflammation, improved clinical outcome was associated with reduced inflammation and profound attenuation of T(h)1 responses and, consistent with these in vivo findings, we confirmed that during in vitro differentiation, IL-27 directly promotes CD4(+) T cell IFN-gamma production through effects on Tbet, a key T(h)1 transcription factor. " 07/01/2008 - "In this study, we identify the transcription factor Nrf2, guardian of redox homeostasis, as such target in a model of LPS-induced inflammation in mouse hippocampus. " 03/01/2007 - "BACKGROUND: Previous studies have shown that mice lacking T-bet, a critical transcription factor for T(H)1 cell differentiation, spontaneously develop airway inflammation with intense eosinophil infiltrates. " 11/01/2005 - "In the present study, we investigated whether redox-sensitive transcription factors were activated as a consequence of DE exposure, consistent with oxidative stress triggering airway inflammation. " Order ALL the reference details at left...
3.	Anoxia (Hypoxia) 02/01/2002 - "Taken together, these findings suggest that HIF-1 may be the major hypoxia-inducible transcription factor in macrophages and that HIF-1-regulated constructs are likely to be effective in macrophage delivery of hypoxia-regulated gene therapy to human tumours." 11/15/2009 - "In conclusion, our study demonstrates that hypoxia induces hUcn2 expression via a specific HRE in the 3'FLR of the hUcn2 gene, which interacts with the transcription factor HIF1alpha. " 03/27/2009 - "In the present study, we determined the role of hypoxia inducible factor-1alpha (HIF-1alpha), which is a transcription factor in response to physiological hypoxia, in regulating expression of AQP4 and AQP9. " 02/01/2009 - "Studies with promoter constructs, including site-directed mutagenesis, transcription factor binding assays, and HIF loss and gain of function showed a central role of HIF-1alpha in transcriptional repression of ENT2 during hypoxia. " 01/01/2009 - "These studies are the first demonstration that the HIF-1alpha transcription factor is targeted directly by Egr1 in hypoxia." Order ALL the reference details at left...
4.	Bipolar Disorder (Mania) 07/15/2008 - "The G-384A variant may alter binding of Sp1/Sp4 transcription factors resulting in an increase in gene transcription and an increase in vulnerability to bipolar disorder." 10/01/2005 - "The gene encoding the transcription factor RFX4 represents an excellent neurobiological and positional candidate gene for Bipolar disorder due to the potential involvement of RFX4 proteins in the regulation of circadian rhythms and the proximity of the locus to numerous linkage signals on chromosome 12q23. " 05/01/2006 - "Reduction of dopamine-related transcription factors Nurr1 and NGFI-B in the prefrontal cortex in schizophrenia and bipolar disorders." 07/15/1998 - "Lithium and sodium valproate (VPA) are effective in the treatment of bipolar disorder (BD) and may function through the regulation of signal transduction pathways and transcription factors such as c-fos and c-Jun, which in turn results to changes in gene expression. " 09/01/2004 - "Valproic acid (VPA), which has demonstrated efficacy in the treatment of bipolar disorder, has been shown to alter components of the phosphoinositide (PI) signaling cascade and to increase gene expression mediated by the transcription factor activator protein 1 (AP-1). " Order ALL the reference details at left...
5.	Carcinoma (Carcinomatosis) 09/10/2007 - "Recent studies have suggested that Runt-related transcription factor 3 (Runx3) is associated with genesis and progression of gastric carcinoma. " 01/01/2003 - "The aim of this study was to assess the putative involvement of two intestine-specific transcription factors, CDX1 and CDX2, in the pathogenesis of gastric IM and gastric carcinoma. " 07/01/2002 - "BACKGROUND: Previous studies have shown that ets-2, a transcription factor, is linked to carcinoma progression. " 08/01/2001 - "Experimental and clinicopathologic study on the relationship between transcription factor Egr-1 and esophageal carcinoma." 11/03/2009 - "Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck." Order ALL the reference details at left...

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Cytokines
3.	Transcription Factor AP-1 (Transcription Factor AP 1)
4.	DNA (Deoxyribonucleic Acid)
5.	Lithium
6.	Curcumin
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Enzymes
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Drug Therapy (Chemotherapy)
3.	Resuscitation
4.	Heterologous Transplantation (Xenotransplantation)
5.	Ligation

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