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Proteasome Endopeptidase Complex (Proteasome)

A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Also Known As:
Proteasome; Multicatalytic Endopeptidase Complex; 20S Proteasome; Ingensin; Macropain; Macroxyproteinase; Multicatalytic Proteinase; Prosome; Complex, Multicatalytic Endopeptidase; Complex, Proteasome Endopeptidase; Endopeptidase Complex, Multicatalytic; Endopeptidase Complex, Proteasome; Proteasome, 20S; Proteinase, Multicatalytic
Networked: 7107 relevant articles (211 outcomes, 662 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Dou, Q Ping: 105 articles (01/2021 - 07/2002)
2. Wang, Xuejun: 53 articles (01/2020 - 09/2004)
3. Liu, Jinbao: 43 articles (01/2021 - 09/2004)
4. Anderson, Kenneth C: 36 articles (01/2022 - 10/2002)
5. Chen, Di: 28 articles (08/2014 - 01/2004)
6. Liu, Ningning: 27 articles (06/2022 - 01/2011)
7. Yang, Huanjie: 26 articles (01/2021 - 05/2006)
8. Orlowski, Robert Z: 25 articles (11/2021 - 08/2002)
9. Linder, Stig: 25 articles (10/2021 - 11/2011)
10. Huang, Hongbiao: 25 articles (09/2018 - 05/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Multiple Myeloma
3. Neurodegenerative Diseases (Neurodegenerative Disease)
4. Hematologic Neoplasms (Hematological Malignancy)
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. Ubiquitin
2. Proteins (Proteins, Gene)
3. Bortezomib (Velcade)
4. Proteasome Inhibitors
5. NF-kappa B (NF-kB)
6. carfilzomib
7. Phosphotransferases (Kinase)
8. Chymotrypsin
9. Dexamethasone (Maxidex)
10. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

Related Therapies and Procedures

1. Therapeutics
2. Radiotherapy
3. Oral Administration
4. Transplantation
5. Immunomodulation