Cyclin D2

A cyclin D subtype which is regulated by GATA4 TRANSCRIPTION FACTOR. Experiments using KNOCKOUT MICE suggest a role for cyclin D2 in granulosa cell proliferation and gonadal development.

Networked: 337 relevant articles (8 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sukumar, Saraswati: 8 articles (05/2011 - 05/2003)
2.	Fackler, Mary Jo: 7 articles (05/2011 - 11/2003)
3.	Mao, Xinliang: 5 articles (04/2011 - 12/2007)
4.	Schimmer, Aaron D: 5 articles (04/2011 - 12/2007)
5.	Argani, Pedram: 5 articles (09/2008 - 12/2003)
6.	Zhu, Wuqiang: 4 articles (01/2021 - 12/2017)
7.	Hurren, Rose: 4 articles (04/2011 - 12/2007)
8.	Campo, Elias: 4 articles (11/2009 - 02/2004)
9.	Wang, Kai: 3 articles (01/2021 - 10/2019)
10.	Chuang, Shih-Sung: 3 articles (01/2020 - 08/2006)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2010 - "Moreover, cyclin D2 dramatically reduced tumor growth and development in Apc(Min/+) mice. " 10/01/2003 - "To study the cell cycle-regulatory factors involved in ovarian, testicular, and adrenal tumor development in vivo, we have bred Inhalpha mutant mice to mice with targeted disruptions of the p27 and cyclin D2 genes. " 01/01/2023 - "Here we report a novel role of cyclin D2 in the regulation of centrosome clustering, which could allow the identification of tumors sensitive to cyclin D2 inhibitors. " 01/01/2023 - "These genes include Cyclin D2 (Ccnd2), which is required for neoplastic cell proliferation in some tumor types. " 01/01/2022 - "Cyclin D2 (CCND2) is abnormally overexpressed in many tumor types and has been associated with tumor cell proliferation. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "In our study, we carried out the MSP assay to evaluation the methylation status at CpG islands in the cyclin D2 promoter in breast cancer cases from the Vietnamese population. " 02/01/2017 - "Our methylation analysis indicates that only promoters of RBL1 (p107), RASSF1A, and cyclin D2 were aberrantly methylated in studied breast cancer cell lines. " 08/01/2008 - "The applicability of cyclin D2 and RARbeta2 methylated markers for the development of a breast tumor screening assay was evaluated. " 09/01/2007 - "514 NDL samples obtained from 150 women selected to represent a wide range of breast cancer risk were evaluated cytologically and by quantitative multiplex methylation-specific PCR for methylation of cyclin D2, APC, HIN1, RASSF1A, and RAR-beta2. " 11/01/2004 - "The APC gene promoter 1A and the promoter region of the cyclin D2 gene were methylated in 42% (14/33) and 70% (23/33) of the breast cancer aspiration fluid samples, respectively. "
3.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 10/01/2005 - "Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma." 01/01/2020 - "In this study we investigated whether the expression of cyclin D2 (CCND2) mRNA in activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) was correlated with the efficacy of Rituximab combined with chemotherapy (R-CHOP) treatment and patient prognosis. "
4.	Multiple Myeloma 01/01/2016 - "Post-transcriptional Modifications Contribute to the Upregulation of Cyclin D2 in Multiple Myeloma." 01/01/2012 - "Inhibition of cell cycle progression by dual phosphatidylinositol-3-kinase and mTOR blockade in cyclin D2 positive multiple myeloma bearing IgH translocations." 03/17/2011 - "Dysregulation of cyclin D2 contributes to the pathogenesis of multiple myeloma, and can occur through translocations that activate MAF/MAFB or MMSET/FGFR3. " 12/01/2007 - "The oncogene c-maf is frequently overexpressed in multiple myeloma cell lines and patient samples and contributes to increased cellular proliferation in part by inducing cyclin D2 expression. " 11/01/2007 - "The oncogene c-Maf was recently found to be overexpressed in approximately 50% of multiple myeloma cases, and a role for c-Maf in promoting cyclin D2 expression has been postulated. "
5.	Myocardial Infarction 01/01/2021 - "Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction." 01/01/2023 - "Experiments in mammalian models of cardiac injury suggest that the cardiomyocyte-specific overexpression of CCND2 (cyclin D2, in humans) improves recovery from myocardial infarction (MI). " 01/01/2018 - "To determine whether overexpression of the cell cycle activator CCND2 (cyclin D2) in hiPSC-CMs can increase the graft size and improve myocardial recovery in a mouse model of myocardial infarction by increasing the proliferation of grafted cells. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	DNA (Deoxyribonucleic Acid)
3.	Rituximab (Mabthera)
4.	Transcription Factors (Transcription Factor)
5.	Cell-Free Nucleic Acids
6.	Anthracyclines
7.	Amitriptyline (Elavil)
8.	sargramostim (Leukine)
9.	Proteins (Proteins, Gene)
10.	Cyclins

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Stem Cell Transplantation
4.	Prostatectomy (Retropubic Prostatectomy)
5.	Hepatectomy