|1.||Leung, Donald Y M: 4 articles (10/2010 - 08/2002)|
|2.||Yorio, Thomas: 4 articles (01/2010 - 12/2005)|
|3.||Clark, Abbot F: 4 articles (01/2010 - 12/2005)|
|4.||Mullol, Joaquim: 3 articles (01/2009 - 01/2003)|
|5.||Picado, C: 3 articles (10/2008 - 08/2004)|
|6.||Pujols, L: 3 articles (10/2008 - 08/2004)|
|7.||Mullol, J: 3 articles (10/2008 - 08/2004)|
|8.||Zhang, Xinyu: 3 articles (03/2008 - 12/2005)|
|9.||Leung, D Y: 3 articles (07/2001 - 04/2000)|
|10.||Hamid, Q A: 3 articles (07/2001 - 04/2000)|
03/28/2005 - "This study was aimed to investigate the relationship between the expression of GRalpha and GRbeta in colonic mucosal cells of patients with UC, the efficacy of GC therapy and the intensity of inflammation. "
03/28/2005 - "There was no significant association between GRalpha/GRbeta expression and the degree of inflammation of UC. "
03/28/2005 - "GRalpha and GRbeta expression in colonic mucosal specimens were investigated by immunohistochemistry, and compared between GC resistant and sensitive groups, and also among various degrees of inflammation. "
09/01/2004 - "No association between the expression of GRalpha and GRbeta and the degree of inflammation was found. "
09/01/2004 - "Then comparative analyses were made on the GRalpha and GRbeta expression between the GC resistant group and GC sensitive group at various levels of inflammation. "
|2.||Asthma (Bronchial Asthma)
12/01/2003 - "Studies done on patients with GC-insensitive asthma demonstrated an overexpression of GC receptor beta (GRbeta), an abnormal splice variant and an endogenous inhibitor of the classic GC receptor alpha. "
01/01/2001 - "Even if the existence of such cells is demonstrated, the role of GRbeta in asthma will remain a matter of controversy because functional studies have given discrepant data."
04/01/2011 - "This finding has been related to nocturnal asthma and an increase in glucocorticoid receptor-beta-expressing cells, associated with corticosteroid-resistant asthma and fatal asthma. "
06/01/2010 - "Steroid dependency in severe asthma is not associated with GRbeta upregulation in lymphocytes or abnormal T-cell reactivity in the presence of GCs. "
01/01/2009 - "Increased GRbeta expression has been reported in bronchial asthma and nasal polyposis, and after incubation of cells with certain proinflammatory stimuli. "
05/01/2000 - "Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis."
02/01/2005 - "[Clinical usefulness of glucocorticoid receptor beta expression and NF-kappaB activity in patients with ulcerative colitis]."
05/01/2000 - "The results show that the expression of hGRbeta mRNA in PBMCs examined by RT-PCR may serve as a novel predictor of glucocorticoid response in ulcerative colitis."
09/01/2004 - "To investigate the relationship of the expression of GRalpha and GRbeta in the colonic mucosal cell of patients with ulcerative colitis to the efficacy of glucocorticoid (GC) therapy and the intensity of inflammation. "
05/01/2007 - "Nevertheless, an association between GC insensitivity and increased GRbeta expression has been reported in asthma, nasal polyposis, and ulcerative colitis, and in vitro, certain pro-inflammatory cytokines upregulate GRbeta expression. "
09/01/2000 - "There was no difference in the expression of GRbeta in emphysema compared with controls. "
09/01/2000 - "There was a significantly greater number of GRbeta immunoreactive cells in fatal asthma compared with emphysema and controls (P <.001 and P <.05, respectively). "
09/01/2000 - "Our aims were to investigate the expression of GRbeta immunoreactivity, an endogenous inhibitor of steroid action previously associated with steroid insensitivity, within the airways of patients who died of slow-onset fatal asthma and to compare its expression in patients with emphysema and in nonasthmatic subjects who died of unrelated causes. "
|5.||Ocular Hypertension (Glaucoma, Suspect)
12/01/2005 - "The decreased amount of GRbeta in glaucomatous TM cells could result in enhanced glucocorticoid responsiveness and ocular hypertension."
01/01/2009 - "To study the expression of glucocorticoid receptors (alpha and beta) in mononuclear cells of peripheral blood (PBMCs) in patients with glucocorticoid-induced ocular hypertension (GIOH) and the relationship between of the expression of GRalpha and GRbeta in PBMCs and its susceptibility to GIOH. "
01/01/2010 - "While chronic glucocorticoid (GC) therapy leads to ocular hypertension in about one third of individuals, almost all primary open-angle glaucoma (POAG) patients show this response and are called "steroid responders." Two differentially spliced isoforms of the glucocorticoid receptor (GR), GRalpha and GRbeta, regulate GC responsiveness in trabecular meshwork (TM) cells. "
|1.||glucocorticoid receptor alpha
|2.||Glucocorticoid Receptors (Glucocorticoid Receptor)
|3.||Messenger RNA (mRNA)
|4.||Protein Isoforms (Isoforms)
|6.||Anti-Inflammatory Agents (Anti-Inflammatories)
|8.||glucocorticoid receptor beta
|10.||Histone Deacetylase 2