Cytoplasmic and Nuclear Receptors (Nuclear Receptors)

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553 relevant articles (11 outcomes, 49 trials/studies) found for this Bio-Agent

Description: Proteins in the cytoplasm or nucleus that specifically bind signaling molecules and trigger changes which influence the behavior of cells. The major groups are the steroid hormone receptors (RECEPTORS, STEROID), which usually are found in the cytoplasm, and the thyroid hormone receptors (RECEPTORS, THYROID HORMONE), which usually are found in the nucleus. Receptors, unlike enzymes, generally do not catalyze chemical changes in their ligands.

Also Known As:

Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Cytoplasmic Hormone Receptors; Cytoplasmic Receptors; Cytosol and Nuclear Receptors; Nuclear Hormone Receptors; Receptors, Cytoplasmic; Receptors, Cytosol and Nuclear; Receptors, Cytosolic and Nuclear; Receptors, Nuclear; Receptors, Nuclear and Cytoplasmic; Receptors, Cytoplasmic Hormone; Receptors, Nuclear Hormone; Cytosolic and Nuclear Receptors; Hormone Receptors, Cytoplasmic; Hormone Receptors, Nuclear; Nuclear and Cytoplasmic Receptors

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 58433

Cytoplasmic and Nuclear Receptors: 553

Steroid Receptors: 1476

Calcitriol Receptors: 1196

Peroxisome Proliferator-Activated Receptors: 771

Aryl Hydrocarbon Receptors: 492

Retinoic Acid Receptors: 464

Thyroid Hormone Receptors: 310

liver X receptor: 145

Melatonin Receptors: 137

soluble guanylyl cyclase: 69

Inositol 1,4,5-Trisphosphate Receptors: 56

Steroidogenic Factor 1: 43

constitutive androstane receptor: 30

Hepatocyte Nuclear Factor 4: 25

lamin B receptor: 9

peroxisomal targeting signal 2 receptor: 9

exportin 1 protein: 7

diazepam-binding inhibitor receptor: 4

peroxisome-targeting signal 1 receptor: 4

signal sequence receptor: 4

phosphatidylinositol receptors: 3

RAR-related orphan receptor A: 3

chicken CXR protein: 1

farnesoid X-activated receptor: 1

human NR6A1 protein: 1

lipophorin receptor: 1

ribosome receptor: 1

signal peptide receptor: 1

ADP-ATP carrier receptor

Aedes aegypti HR3 protein

Ambystoma mexicanum aDOR1 protein

Arabidopsis TRN1 protein

Arabidopsis VSR3 protein

Bacteria FtsY protein

Bombyx mori HR3a protein

C elegans DAF-12 protein

C elegans FAX-1 protein

C elegans Kel-8 protein

C elegans matefin protein

C elegans NHR-2 protein

C elegans Nhr-40 protein

C elegans NHR-49 protein

C elegans Nhr-6 protein

C elegans NHR-60 protein

C elegans Nhr-67 protein

C elegans RPN-10 protein

C elegans sex-1 protein

C elegans UNC-55 protein

C-elegans nhr-8 protein

cation-dependent mannose-6-phosphate receptor

Ciona intestinalis CiNR1 protein

cminsp3 pm

Cucurbita PAC vesicle 72-kDa protein

Dirofilaria immitis NHR-7 protein

Drosophila dissatisfaction protein

Drosophila E78 protein

Drosophila Hr38 protein

Drosophila HR4 protein

Drosophila Hr46 protein

Drosophila Hr78 protein

Drosophila Hr96 protein

Drosophila RACK1 protein

Drosophila Smr protein

Galleria GHR3 protein

human ribosome receptor p180

human SNUPN protein

human TBL1XR1 protein

HZF-2alpha

HZF-2beta

inositol hexakisphosphate receptor

inositol polyphosphate receptor

inositol-1,3,4,5,6-pentakisphosphate receptor

inositol-1,3,4,5-tetrakisphosphate receptor

mammalian BHKp23 protein

mammalian p180

Manduca sexta MHR4 protein

mouse cytoplasmic CAR retention protein

Neurospora crassa MOM19 protein

Experts

1.	Tontonoz, Peter: 3 articles (07/2008 - 01/2004)
2.	Nauman, Alicja: 2 articles (11/2007 - 01/2002)
3.	Puzianowska-Kuznicka, Monika: 2 articles (11/2007 - 01/2002)
4.	Glass, Christopher K: 2 articles (10/2006 - 01/2006)
5.	Grunfeld, Carl: 2 articles (10/2006 - 02/2004)
6.	Denkert, Carsten: 2 articles (03/2006 - 06/2005)
7.	Lichtenegger, Werner: 2 articles (03/2006 - 06/2005)
8.	Sun, Pengming: 2 articles (03/2006 - 06/2005)
9.	Sehouli, Jalid: 2 articles (03/2006 - 06/2005)
10.	Wei, Lihui: 2 articles (03/2006 - 06/2005)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2009 - "For example, agents targeting nuclear receptors over-expressed in tumors can hone in on malignant tissue and result in improved chemotherapeutic treatments. " 01/01/2009 - "This review will summarize their mode of action, prognostic/therapeutic relevance, as well as preclinical and clinical studies currently targeting nuclear receptors in this tumor entity." 06/01/2009 - "Since this directly impacts signaling through nuclear receptors, these discoveries should significantly impact the development of novel therapeutic strategies directed against multiple types of cancer." 12/01/2008 - "Aberrant expression or impaired function of these nuclear receptors has been linked to diverse types of cancer. " 09/01/2008 - "Novel orphan nuclear receptors-coregulator interactions controlling anti-cancer drug metabolism." Order ALL the reference details at left...
2.	Liver Diseases (Liver Disease) 10/15/2009 - "AIMS: To review the new insights brought by the study of nuclear receptors to our understanding of the molecular basis of various liver diseases, and to summarize some of the recent studies that evaluated the efficacy of targeting nuclear receptor as a new approach in treating liver diseases. " 10/15/2009 - "These findings led to the introduction of targeting nuclear receptors as treatment strategies for various liver diseases. " 10/15/2009 - "BACKGROUND: The important role of nuclear receptors and their contribution to liver function in both physiological and pathological conditions has come to attention in recent years and has advanced our understanding of several liver diseases. " 10/15/2009 - "Review article: nuclear receptors and liver disease--current understanding and new therapeutic implications." 01/01/2009 - "This article will review the current knowledge on nuclear receptors and their potential role in the treatment of cholestatic liver diseases." Order ALL the reference details at left...
3.	Infection 07/28/2009 - "Drugs targeting, for example, receptors of viral entry, host metabolism or nuclear receptors, which are factors required to complete the HCV life cycle, may be more effective in combating the viral infection. " 06/17/2008 - "Real-time RT-PCR analyses demonstrate that infection with lentivectors does not alter hepatic hallmarks such as the expression of the nuclear receptors CAR, PXR, RXR alpha, or HNF4 alpha, or expression of the secretory protein, albumin. " 12/01/2001 - "Our results suggest that interactions between nuclear receptors and NRREs present in the HBV genome may play critical roles in regulating its transcription and replication during HBV infection of hepatocytes." 02/01/1997 - "Agonists and antagonists capable of regulating the activity of these nuclear receptors may permit the modulation of HBV transcription and consequently replication during viral infection." 12/01/1997 - "These findings indicate that appropriate ligands to nuclear receptors may be useful in the treatment of HBV infection." Order ALL the reference details at left...
4.	Prostatic Neoplasms (Prostate Cancer) 08/01/2007 - "We have recently described IGFBP-3-induced mitochondrial translocation of the nuclear receptors RXRalpha/Nur77 in the induction of prostate cancer (CaP) cell apoptosis. " 03/01/2007 - "Our results suggest that PELP1 functions as a molecular adaptor, coupling FHL2 with nuclear receptors, and PELP1-FHL2 interactions may have a role in prostate cancer progression." 03/01/2008 - "BAG-1 modulates the function of various nuclear hormone receptors, including the oestrogen receptor, and BAG-1 can influence the in vitro action of anti-hormonal therapies such as cyproterone acetate in prostate cancer. " 08/01/2005 - "This review provides an overview of published information on possible nongenomic activities of the androgen receptor (AR) and other nuclear receptors, focusing on the potential involvement of these processes in prostate cancer. " 01/01/2005 - "Cholecalciferol (vitamin D3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells." Order ALL the reference details at left...
5.	Cholestasis 07/01/2008 - "Furthermore, the complex networks between nuclear hormone receptors and regulated genes are illustrated and implications of targeting these receptors for the treatment of cholestasis are discussed." 06/01/2008 - "To investigate how the liver adapts to chronic obstructive cholestasis, liver samples from infants with early- and late-stage cholestasis were analyzed for changes in the levels of hepatocyte transporters and nuclear receptors. " 02/11/2006 - "Nuclear receptors, bile-acid detoxification, and cholestasis." 01/01/2009 - "Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis." 11/01/2007 - "Since most biotransformation processes in the liver are under the control of nuclear receptors (NR), treatment modalities aiming to stimulate or inhibit NR expression are at present tested in animal models of APAP toxicity or cholestasis. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Ligands
3.	Hormones
4.	Retinoids
5.	Vitamin D
6.	Steroid Receptors (Steroid Receptor)
7.	Monoclonal Antibodies
8.	PPAR gamma
9.	Glucose (Dextrose)
10.	Retinoid X Receptors (Retinoid X Receptor)

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Hepatectomy
5.	Transplants (Transplant)

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