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Protein Isoforms (Isoforms)

Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
Also Known As:
Isoforms; Protein Splice Variants; Isoform, Protein; Isoforms, Protein; Splice Variant, Protein; Variant, Protein Splice; Variants, Protein Splice; Isoform; Protein Isoform; Protein Splice Variant; Splice Variants, Protein
Networked: 26045 relevant articles (418 outcomes, 3061 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Supuran, Claudiu T: 357 articles (12/2022 - 08/2003)
2. Scozzafava, Andrea: 74 articles (01/2016 - 08/2003)
3. Angeli, Andrea: 64 articles (12/2022 - 01/2016)
4. Nocentini, Alessio: 64 articles (12/2022 - 11/2015)
5. Vullo, Daniela: 61 articles (01/2022 - 08/2003)
6. Carta, Fabrizio: 58 articles (12/2021 - 10/2009)
7. Ceruso, Mariangela: 39 articles (08/2019 - 12/2013)
8. Wang, Wei: 36 articles (11/2022 - 08/2004)
9. Bates, David O: 34 articles (01/2022 - 07/2002)
10. Wang, Jing: 33 articles (01/2022 - 04/2007)

Related Diseases

1. Neoplasms (Cancer)
08/15/2020 - "The target compounds showed promising inhibitory activity against the four examined human (h) CA isoforms; I, II, IX and XII. Compounds 4-18 displayed variable inhibition constants, ranging as follows: 7.6-782.8 nM for hCA I, 34.4-412.1 nM for hCA II, 29.1-2225.3 nM for hCA IX and 8.8-429.4 nM for hCA XII. Compound 9, the most potent against the tumor-specific CA IX/CA XII (KI = 29.1 and 8.8 nM) gives the possibility to evaluate its cytotoxicity and selectivity in vitro against HepG-2, HCT-116 and MCF-7 cancer cell lines. "
02/15/2016 - "Certain selected derivatives were tested for their ability to inhibit four isoforms of the metalloemzyme CA, namely, CA I, CA II, CA IX and CA XII. Compound 3c was found to be highly effective in inhibiting the cancer cell proliferation. "
01/01/2023 - "Results: None of the developed compounds displayed inhibitory potential against off-target isoforms hCA I and II. However, they effectively inhibited tumor-associated hCA IX and XII. Conclusion: The present study suggests potent lead compounds as selective hCA IX and XII inhibitors with anticancer activity."
02/15/2000 - "on the flank or directly into the peritoneal cavity, with M1 cells stably expressing WT1 +KTS isoforms exhibited a marked decrease in tumor formation compared with control groups. "
07/19/2022 - "Our study revealed that combining radiation and the PI3K-α isoform improved radiosensitivity that resulted in a significant delay in tumor growth and improved survival rate."
2. Inflammation (Inflammations)
3. Breast Neoplasms (Breast Cancer)
4. Ischemia
5. Obesity

Related Drugs and Biologics

1. Protein Isoforms (Isoforms)
2. Proteins (Proteins, Gene)
3. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
5. Enzymes
6. Nitric Oxide Synthase (NO Synthase)
7. Glucose (Dextrose)
8. Messenger RNA (mRNA)
9. Biomarkers (Surrogate Marker)
10. Apolipoproteins E (ApoE)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Intramuscular Injections
4. Immunotherapy
5. Aftercare (After-Treatment)