Abstract | OBJECTIVE: METHODS:
GRalpha expression and GRbeta expression in the colonic mucosal specimens were assessed by means of immunohistochemistry. Then comparative analyses were made on the GRalpha and GRbeta expression between the GC resistant group and GC sensitive group at various levels of inflammation. A normal response group was observed for comparison. RESULTS: The staining intensities of both GRalpha and GRbeta in colonic mucosal specimens showed significant differences between the GC resistant group, GC sensitive group and normal response group. No association between the expression of GRalpha and GRbeta and the degree of inflammation was found. CONCLUSION:
|
Authors | Hu Zhang, Qin Ouyang, Zhong-hui Wen, Wei-ping Liu, Dai-yun Chen, Feng-yuan Li |
Journal | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
(Sichuan Da Xue Xue Bao Yi Xue Ban)
Vol. 35
Issue 5
Pg. 630-3
(Sep 2004)
ISSN: 1672-173X [Print] China |
PMID | 15460404
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Glucocorticoids
- Receptors, Glucocorticoid
- glucocorticoid receptor alpha
- glucocorticoid receptor beta
|
Topics |
- Adult
- Colitis, Ulcerative
(drug therapy, metabolism)
- Colon
(metabolism)
- Down-Regulation
- Drug Resistance
- Female
- Glucocorticoids
(metabolism, therapeutic use)
- Humans
- Immunohistochemistry
- Intestinal Mucosa
(metabolism)
- Male
- Receptors, Glucocorticoid
(metabolism)
|