Proximal myopathy caused by latrogenic phosphate depletion.

Abstract

Severe proximal myopathy associated with hypophosphatemia developed in three patients with chronic renal failure who had been treated with aluminum hydroxide gel. The syndrome was characterized by severe pain, muscular stiffness, and weakness. The illness was originally misdiagnosed both as uremic myopathy and as an exacerbation of rheumatoid arthritis. In one patient, the correct diagnosis was made when symptomatic relief corresponded to the rise of serum phosphate levels. Discontinuation of antacid therapy was followed by gradual recovery. Oral sodium phosphate brought prompt alleviation of muscular pain and stiffness.

• Authors: M Ravid, M Robson
• Journal: JAMA (JAMA) Vol. 236 Issue 12 Pg. 1380-1 (Sep 20 1976) ISSN: 0098-7484 [Print] United States
• PMID: 989096 (Publication Type: Case Reports, Journal Article)

Chemical References

• Phosphates
• Aluminum Hydroxide

Topics

• Adult
• Aluminum Hydroxide (adverse effects, therapeutic use)
• Female
• Humans
• Hyperparathyroidism, Secondary (prevention & control)
• Iatrogenic Disease
• Kidney Failure, Chronic (drug therapy)
• Male
• Middle Aged
• Muscular Diseases (etiology)
• Phosphates (deficiency)
• Pruritus (prevention & control)