Abstract | BACKGROUND: Topical corticosteroids are often used in the treatment of psoriasis, but long-term use may be associated with serious adverse events such as tachyphylaxis or atrophy of the skin. Tazarotene, a new topical retinoid, has demonstrated significant clinical benefits but can cause mild to moderate local irritation. OBJECTIVE: We evaluate whether a combination treatment of topical tazarotene and a topical corticosteroid would increase efficacy while reducing the incidence of local adverse events associated with a topical retinoid. METHODS: Three hundred patients enrolled in an investigator-masked study were randomly assigned to 1 of 4 treatment groups: tazarotene 0.1% gel in combination with placebo cream, or with a low-, mid-, or high-potency corticosteroid cream, for 12 weeks of treatment and a posttreatment follow-up at week 16. RESULTS:
Tazarotene 0.1% gel in combination with a mid- or high-potency corticosteroid, when compared with tazarotene plus placebo cream, achieved significantly greater reductions in scaling, erythema, and overall lesional severity, and a decreased incidence of adverse events. CONCLUSION:
|
Authors | M G Lebwohl, D L Breneman, B S Goffe, J R Grossman, M R Ling, J Milbauer, S H Pincus, R G Sibbald, L J Swinyer, G D Weinstein, D A Lew-Kaya, J C Lue, J R Gibson, J Sefton |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 39
Issue 4 Pt 1
Pg. 590-6
(Oct 1998)
ISSN: 0190-9622 [Print] United States |
PMID | 9777766
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Chemical References |
- Adrenal Cortex Hormones
- Gels
- Keratolytic Agents
- Nicotinic Acids
- Ointments
- tazarotene
|
Topics |
- Administration, Cutaneous
- Adrenal Cortex Hormones
(administration & dosage, adverse effects, therapeutic use)
- Adult
- Canada
- Drug Therapy, Combination
- Female
- Gels
- Humans
- Keratolytic Agents
(administration & dosage, adverse effects, therapeutic use)
- Male
- Middle Aged
- Nicotinic Acids
(administration & dosage, adverse effects, therapeutic use)
- Ointments
- Psoriasis
(drug therapy)
- Severity of Illness Index
- Time Factors
- Treatment Outcome
- United States
|