Fixed drug eruption from amoxycillin.

Abstract

We present a case of fixed drug eruption on the genital mucosa induced by amoxycillin. Topical provocation was carried out, applying amoxycilin (10% pet) on the glans penis. No reaction was observed. Oral challenge with amoxycillin was followed by pruritic erythema on the glans penis 6 hours after the intake of 125 mg. The study of cross-reactivity to other betalactams showed good tolerance of phenoxymethyl-penicillin, which shares an identical nuclear structure with amoxycillin. The patient also tolerated cephadroxil, a cephalosporin with a side chain identical to that of amoxycillin. On reviewing the literature we have only found three reports of fixed drug eruption fue to amoxycillin.

• Authors: I Jiménez, E Antón, I Picáns, I Sánchez, M D Quiñones, J Jerez
• Journal: Allergologia et immunopathologia (Allergol Immunopathol (Madr)) 1997 Sep-Oct Vol. 25 Issue 5 Pg. 247-8 ISSN: 0301-0546 [Print] Singapore
• PMID: 9395009 (Publication Type: Case Reports, Journal Article)

Chemical References

• Penicillins
• Amoxicillin

Topics

• Adult
• Amoxicillin (adverse effects)
• Drug Eruptions (etiology)
• Humans
• Male
• Penicillins (adverse effects)
• Penile Diseases (chemically induced)
• Skin Tests