Abstract |
Z-103 is a chelate compound consisting of zinc ion and L-carnosine. In this study, we investigated the protective effect of Z-103 against colonic damage induced by 2,4,6-trinitrobenzene sulfonic acid (TNB) in rats. Colonic inflammation was induced by administering TNB dissolved in 50% ethanol (120 mg/ml) in male Wistar rats (total volume of 0.25 ml per rat) following a 48-hour fast. After the administration of TNB, Z-103 was given at a dose of 30 mg/kg per rat for 1 week. A second group of rats received sulfasalazine (SASP) at 300 mg/kg and a third group of rats received 30 mg/kg of ZnSO4 for 1 week. Colonic inflammation was assessed 1 week following TNB administration. Both macro- and microscopic evaluation showed that the inflammatory responses induced by TNB were reduced by treatment with Z-103, SASP and ZnSO4. The score (graded from 0 to 5 according to the macroscopic lesions) and colonic wet weight (distal 8 cm of the colon) were significantly decreased by treatment with Z-103, SASP and ZnSO4. The increase in thiobarbituric acid-reactive substances in the colonic mucosa following TNB administration were inhibited in the Z-103 and SASP groups. These results suggest that Z-103 is as effective against TNB-induced colitis as SASP.
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Authors | T Yoshikawa, T Yamaguchi, N Yoshida, H Yamamoto, S Kitazumi, S Takahashi, Y Naito, M Kondo |
Journal | Digestion
(Digestion)
Vol. 58
Issue 5
Pg. 464-8
( 1997)
ISSN: 0012-2823 [Print] Switzerland |
PMID | 9383638
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Antioxidants
- Organometallic Compounds
- Zinc Compounds
- polaprezinc
- Sulfasalazine
- Zinc Sulfate
- Carnosine
- Trinitrobenzenesulfonic Acid
- Zinc
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Topics |
- Animals
- Anti-Ulcer Agents
(therapeutic use)
- Antioxidants
(therapeutic use)
- Carnosine
(analogs & derivatives, therapeutic use)
- Colitis
(chemically induced, drug therapy, pathology)
- Colon
(pathology)
- Intestinal Mucosa
(pathology)
- Male
- Organometallic Compounds
(therapeutic use)
- Rats
- Rats, Wistar
- Sulfasalazine
(therapeutic use)
- Trinitrobenzenesulfonic Acid
- Zinc
(therapeutic use)
- Zinc Compounds
- Zinc Sulfate
(therapeutic use)
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