Carnosine

01/01/2009 - "To compare the efficacy of L-carnosine and derivatives in inhibiting/reversing oxidative stress-induced reactions relevant for cataract pathogenesis. "
12/01/2019 - "This study suggests carnosine supplementation as a possible preventive strategy against development of the diabetic cataracts in human."
06/01/2017 - "In summary, our study suggests that carnosine may have therapeutic potential in preventing senile cataracts linked with the increased lenticular DHA generation, particularly under pathological conditions associated with the oxidative stress."
10/10/2015 - "This study presents a simple but sensitive HPLC chromatographic method with a stability-indicating assay for determination and physicochemical characterisation of L-carnosine, a promising senile cataract prophylactic agent. "
09/01/2007 - "Some anti-cataract drugs, such as carnosine, have now reached clinical trials and showed encouraging results that warrant further investigation. "

07/01/2000 - "In experimental cerebral ischemia, carnosine decreases mortality and is beneficial for neurological conditions of the animals. "
04/26/2020 - "Both d- and l-carnosine exhibited similar efficacy against mouse focal cerebral ischemia. "
11/01/2007 - "We investigated the efficacy of carnosine in a mouse model of permanent focal cerebral ischemia. "
04/24/2013 - "Considerable studies have showed that L-carnosine provides anti-oxidative and anti-apoptotic roles in the animal models of global or focal cerebral ischemia. "
11/01/2007 - "The purposes of this study were to determine whether carnosine is neuroprotective in permanent focal cerebral ischemia and to determine potential mechanisms of neuroprotection. "

03/01/2002 - "Administration of carnosine (10 mg/day) for 15 days either concurrent with infection, 2 and 4 weeks post-infestation was effective in reducing differential worm burden. "
08/01/2000 - "Administration of carnosine (10 mg/day) for 15 days either concurrent with infection, 2 and 4 weeks post exposure was effective in reducing worm burden and egg count only when given at the time of infection. "
05/01/2001 - "Administration of carnosine (10 mg/day) for 15 days concurrent with infection effectively reduced worm burden and egg count. "
01/01/2022 - "This study demonstrates that COVID19 infection results in a unique nasopharyngeal metabolomic signature with carnosine and LysoPCaC18:2 as potential therapeutic targets."
11/05/2020 - "Thus, we propose to consider salicyl-carnosine as a potential drug for the treatment of patients with severe cases of COVID-19 infection."

09/01/2021 - "In contrast, administration of L-carnosine to G4 rabbits revealed marked improvement of all previously harmful changes in G2 rabbits, indicating the cytoprotective effects of L-carnosine against IL-1α-induced inflammation of LGs. "
01/01/2023 - "In the present review, we examined the protective role that carnosine could exert in the context of T2DM, CVD, and AD, which show common pathogenic mechanisms including oxidative stress, inflammation, and aggregation phenomena. "
01/01/2023 - "An increase in circulating carnosine may characterize depressive episodes and may represent a protective homeostatic reaction against MDD-related oxidative stress and inflammation."
12/14/2022 - "Consequently, L-carnosine treatment ameliorated fibrogenesis in fibroblasts and alveolar epithelial cells, and inflammation induced by ROS and CSE exposure was ameliorated. "
12/01/2021 - "The results also showed that carnosine strongly inhibited podocyte inflammation and podocyte pyroptosis in vitro. "

01/01/2013 - "Treatment with carnosine at a dose of 5 mg/day for 6 weeks was effective in preventing cognitive decline, as the transgenic group fed with HFD and treated with carnosine displayed a level of cognition comparable to controls. "
01/01/2023 - "Here, we report that carnosine ameliorates diabetes-associated cognitive decline in vivo through the modulation of autophagy. "
11/27/2023 - "Further studies are needed in people with early cognitive impairment with longer follow-up duration and standardization of carnosine doses to delineate the true effect. "
03/04/2021 - "These data suggest a preliminary evidence of clinical efficacy of carnosine against cognitive decline both in elderly subjects and mild cognitive impairment (MCI) patients, although larger and long-term clinical studies are needed in MCI patients (with or without depression) to confirm the therapeutic potential of carnosine."
03/04/2021 - "Different clinical studies have been conducted to evaluate the impact of carnosine supplementation against cognitive decline in elderly and AD subjects. "