Persistence of autonomous ovarian activity after discontinuation of therapy for precocious puberty in McCune-Albright syndrome.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the possibility of persistence of autonomous ovarian activity in girls with McCune-Albright syndrome (MAS) after withdrawal of medroxyprogesterone therapy administered for precocious puberty.

DESIGN, SETTING, AND PARTICIPANTS:

Five girls with MAS were followed-up 1.2 to 8.5 years after the end of treatment. The girls underwent luteinizing hormone-releasing hormone (LH-RH) tests, estradiol (E2) basal measurement, and pelvic ultrasound two times in the follow-up period.

RESULTS:

Menses resumed in four of five girls, 1.4 +/- 0.9 years after the end of treatment, at chronologic age of 11.3 +/- 1.3 years. Cycles for all girls were irregular. Three patients presented inadequate E2 levels (from 56 to 320 pg/mL) associated with low or absent gonadotropin response to LH-RH tests. The pelvic ultrasound showed ovarian cysts at the time of the study.

CONCLUSION:

These hormonal and ultrasonographic findings provide evidence of persistence of autonomous ovarian activity in some young women with MAS.

• Authors: M E Escobar, M Gryngarten, H Domené, G Ropelato, M R López, C Bergadá
• Journal: Journal of pediatric and adolescent gynecology (J Pediatr Adolesc Gynecol) Vol. 10 Issue 3 Pg. 147-51 (Aug 1997) ISSN: 1083-3188 [Print] United States
• PMID: 9288659 (Publication Type: Journal Article)

Chemical References

• Progesterone Congeners
• Estradiol
• Luteinizing Hormone
• Follicle Stimulating Hormone
• Medroxyprogesterone

Topics

• Child
• Estradiol (blood)
• Female
• Fibrous Dysplasia, Polyostotic (blood, complications, physiopathology)
• Follicle Stimulating Hormone (blood)
• Follow-Up Studies
• Humans
• Luteinizing Hormone (blood)
• Medroxyprogesterone (therapeutic use)
• Ovary (diagnostic imaging, physiopathology)
• Progesterone Congeners (therapeutic use)
• Puberty, Precocious (blood, complications, drug therapy, physiopathology)
• Ultrasonography