Abstract |
In order to study the interrelation between bcl-2, P53 and c-erbB-2 protein, their expression in 145 breast carcinomas were observed by immunohistochemical LSAB method. 19 cases were negative, 12 were positive for the three oncoproteins. 19 cases were positive for c-erbB-2 only. 20 positive for P53 only and 20 positive for bcl-2 only. 26 cases were positive for both P53 and c-erbB-2, 17 for both c-erbB-2 and bcl-2, 12 for both P53 and bcl-2. Strong inverse correlation was found between the expression of P53 and bcl-2 (P < 0.001). The P53 expression or the expression of both P53 and c-erbB-2 correlated with low histological grade, while the bcl-2 expression correlated with high histological grade (P < 0.05). The necrosis in tumors with only bcl-2 expression was less than those with c-erbB-2 or both c-erbB-2 and P53 expression (P < 0.02). Mitosis count was lower in tumors with only bcl-2 expression than those with expression of both c-erbB-2 and P53 (P < 0.05). The expression of c-erbB-2 and P53 proteins are associated with poor prognosis (P < 0.02, P < 0.05) but not affected by bcl-2. The results suggest that bcl-2, P53 and c-erbB-2 are involved in tumorigenesis and development of breast carcinoma with different biological effects.
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Authors | L Gao, H Ding, Y Deng |
Journal | Zhonghua bing li xue za zhi = Chinese journal of pathology
(Zhonghua Bing Li Xue Za Zhi)
Vol. 25
Issue 3
Pg. 165-8
(Jun 1996)
ISSN: 0529-5807 [Print] China |
PMID | 9275673
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Proto-Oncogene Proteins c-bcl-2
- Tumor Suppressor Protein p53
- Receptor, ErbB-2
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Topics |
- Adult
- Aged
- Breast Neoplasms
(genetics, pathology)
- Carcinoma, Ductal, Breast
(genetics, pathology)
- Female
- Follow-Up Studies
- Humans
- Immunohistochemistry
- Middle Aged
- Proto-Oncogene Proteins c-bcl-2
(biosynthesis)
- Receptor, ErbB-2
(biosynthesis)
- Tumor Suppressor Protein p53
(biosynthesis)
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