Abstract | BACKGROUND: METHODS AND RESULTS:
Tumor specimens (n = 65) were frozen in liquid nitrogen at the time of resection. Fourteen low-grade tumors, 40 high-grade tumors, and 11 pulmonary metastases were analyzed. Glutathione concentrations and GGTP activity were significantly lower in low-grade (3.97 +/- 0.7 nmol/mg protein and 1.07 +/- 0.2 U/mg protein) than in high-grade (8.98 +/- 1.2 nmol/mg protein, p < 0.001; 2.10 +/- 0.4 U/mg protein, p < 0.002) tumors and pulmonary metastases (10.05 +/- 1.8 nmol/mg protein, p < 0.008; 3.14 +/- 2.8 U/mg protein, p < 0.04). While GCS activity was lower in low-grade (0.81 +/- 0.3 nmol/mg protein/h) than high-grade (1.49 +/- 0.5 nmol/mg protein/h) tumors and pulmonary metastases (1.03 +/- 0.2 nmol/mg protein/h), these differences were not significant. In those patients with a high-grade tumor presenting with a local recurrence, glutathione levels were higher in those patients who had received preoperative doxorubicin-based chemotherapy (9.25 +/- 1.7 nmol/mg protein; n = 7) than in those who had no preoperative chemotherapy (4.71 +/- 3.1 nmol/mg protein; n = 4, p = 0.08). CONCLUSIONS:
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Authors | S N Hochwald, D M Rose, M F Brennan, M E Burt |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 4
Issue 4
Pg. 303-9
(Jun 1997)
ISSN: 1068-9265 [Print] United States |
PMID | 9181229
(Publication Type: Journal Article)
|
Chemical References |
- gamma-Glutamyltransferase
- Glutamate-Cysteine Ligase
- Glutathione
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Drug Resistance, Neoplasm
- Extremities
- Female
- Glutamate-Cysteine Ligase
(metabolism)
- Glutathione
(metabolism)
- Humans
- Lung Neoplasms
(secondary)
- Male
- Middle Aged
- Sarcoma
(chemistry, enzymology, secondary)
- Soft Tissue Neoplasms
(chemistry, enzymology, pathology)
- gamma-Glutamyltransferase
(metabolism)
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