Abstract | PURPOSE: To compare the efficacy of propofol in a subhypnotic dose (10 mg iv), droperidol (1.25 mg iv), or metoclopramide (10 mg iv) in the treatment of PONV in the post anaesthesia care unit (PACU). METHODS: In a prospective, randomized, double-blind protocol, over four months, all eligible inpatients and outpatients were asked to give their consent to be included in the study should they suffer PONV in the PACU. They received a standardized general anaesthetic without any prophylactic antiemetic drug. In the recovery room, patients complaining of persistent nausea (lasting more than ten minutes) and/or experiencing at least two episodes of retching or vomiting were given one of the three study drugs. Recurrence of retching or vomiting was recorded for 60 min after administration of the study drug and nausea severity was assessed on a visual analog scale. Patients still complaining of PONV 30 min after administration of the study drug received a rescue medication ( dimenhydrinate). RESULTS: CONCLUSION:
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Authors | G Lacroix, M R Lessard, C A Trépanier |
Journal | Canadian journal of anaesthesia = Journal canadien d'anesthesie
(Can J Anaesth)
Vol. 43
Issue 2
Pg. 115-20
(Feb 1996)
ISSN: 0832-610X [Print] United States |
PMID | 8825535
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antiemetics
- Metoclopramide
- Droperidol
- Propofol
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Topics |
- Adult
- Antiemetics
(therapeutic use)
- Double-Blind Method
- Droperidol
(therapeutic use)
- Female
- Humans
- Male
- Metoclopramide
(therapeutic use)
- Middle Aged
- Nausea
(prevention & control)
- Postoperative Complications
(prevention & control)
- Propofol
(therapeutic use)
- Prospective Studies
- Vomiting
(prevention & control)
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