Droperidol

A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)

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Networked: 860 relevant articles (189 outcomes, 162 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Fujii, Yoshitaka: 14 articles (01/2018 - 05/2002)
2.	Gan, Tong J: 9 articles (07/2013 - 07/2002)
3.	White, Paul F: 5 articles (01/2007 - 07/2002)
4.	Fujii, Y: 5 articles (03/2001 - 01/2000)
5.	Tanaka, H: 5 articles (03/2001 - 01/2000)
6.	Tanaka, Hiroyoshi: 4 articles (01/2018 - 05/2002)
7.	Habib, Ashraf S: 4 articles (02/2008 - 04/2004)
8.	Tzeng, J I: 4 articles (02/2008 - 09/2000)
9.	Wang, J J: 4 articles (02/2008 - 09/2000)
10.	Cabrera, Daniel: 3 articles (02/2022 - 01/2020)

Related Diseases

1.	Postoperative Nausea and Vomiting (PONV) 09/01/1999 - "Treatment with droperidol was more effective when the baseline risk for PONV was higher than 25% for early PONV and 35% for late PONV. " 06/01/2021 - "Prophylactic doses of droperidol are effective in preventing postoperative nausea and vomiting (PONV). " 09/01/2005 - "All treatment groups, except droperidol during the postoperative 3-24 h, were effective for prevention of postoperative nausea and vomiting during the postoperative 0-24 h." 09/01/2001 - "The continuous epidural administration of droperidol is effective in prevention of postoperative nausea and vomiting and the effect lasts during its infusion with no side effects." 09/01/2000 - "Droperidol was effective for this purpose with incidence of PONV of 25% (P < 0.05). "
2.	Vomiting 05/01/1981 - "The results showed that the dose of droperidol used in this study was very effective in reducing vomiting in children 11 to 15 years of age. " 05/01/1995 - "There was a significant reduction in the incidence of vomiting in the recovery room (1.4% vs 9.2%, P < 0.005) and in the day ward (9.4% vs 18.3%, P < 0.05) in patients receiving droperidol. " 01/01/1992 - "Droperidol seems to be more effective in reducing severe vomiting. " 01/01/1992 - "Droperidol was more effective in reducing severe vomiting. " 09/01/2003 - "In controls, the incidence of vomiting was 24.4%; with droperidol 5 micro g, it was 23.2% (NNT compared with control, 82 [7 to -8.5]); with 15 micro g, it was 22.0% (NNT, 41 [6.5 to -9.6]); and with 50 micro g, it was 12% (NNT, 8.1 [4.2-142]). "
3.	Nausea 01/01/2016 - "A 75-year-old postoperative patient was given a single low dose of droperidol to treat persistent nausea. " 01/01/2016 - "If nausea persists despite initial treatment, droperidol, a butyrophenone with anti-dopaminergic activity, can be very effective. " 09/01/2009 - "Over 24 h, nausea was reduced from 42.9% in the control to 32.0% in the droperidol group, corresponding to a relative risk (RR) of 0.75 (95% CI from 0.66 to 0.84). " 10/01/2003 - "Droperidol trended toward a greater mean reduction of nausea than placebo at 5 minutes (20 versus 4, p=0.077). " 09/01/2003 - "In controls, the incidence of nausea was 48.8%; with droperidol 5 micro g, it was 42.7% (NNT compared with control, 16 [95% confidence interval, 4.7 to -11]); with 15 micro g, it was 32.9% (NNT, 6.3 [3.3-100]); and with 50 micro g, it was 21.7% (NNT, 3.7 [2.4 to 7.6]). "
4.	Strabismus (Squint) 06/01/1990 - "Droperidol-induced extrapyramidal symptoms in an adolescent following strabismus surgery." 03/01/1981 - "Low doses (0.05 mg/kg) of intravenously administered droperidol were given intraoperatively to randomly assigned pediatric strabismus patients in a controlled double-masked paradigm. " 07/01/1991 - "To determine whether a low dose of droperidol is as effective as a high dose in preventing vomiting after pediatric strabismus surgery. " 07/01/1991 - "Droperidol 20 microgram/kg is as effective as droperidol 75 microgram/kg in preventing vomiting after pediatric strabismus surgery. " 10/01/1994 - "Droperidol can reduce the high incidence of vomiting after pediatric strabismus surgery; however, its use may be associated with sedation, delayed hospital discharge, dysphoria and extrapyramidal signs. "
5.	Migraine Disorders (Migraine) 06/01/1997 - "Droperidol is effective and safe in treating status migrainosus or refractory migraine. " 01/01/2002 - "The objective of the study was to further assess the efficacy of intramuscular droperidol for the treatment of acute migraine headache. " 02/01/2015 - "To evaluate the safety and efficacy of droperidol for the relief of acute migraine headaches. " 01/01/2002 - "A randomized clinical trial to assess the efficacy of intramuscular droperidol for the treatment of acute migraine headache." 02/01/2015 - "The search was conducted to identify randomized controlled trials comparing droperidol with placebo or an active control in adult patients with acute migraine headaches that were published in English. "

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Related Therapies and Procedures

1.	Laparoscopic Cholecystectomy
2.	Therapeutics
3.	General Anesthesia
4.	Tonsillectomy
5.	Analgesia