Antimüllerian hormone as a serum marker of granulosa cell tumorsof the ovary: comparative study with serum alpha-inhibin and estradiol.

Abstract

OBJECTIVE:

Our purpose was to evaluate serum antimüllerian hormone as a marker for granulosa cell tumors.

STUDY DESIGN:

Serum antimüllerian hormone concentrations were determined in 16 patients with an adult-type granulosa cell tumor; in female patients with ovarian adenocarcinoma, benign ovarian cysts, or extraovarian cancers; and in normal premenopausal and postmenopausal women. Serum antimüllerian hormone, alpha-inhibin, and estradiol levels were compared in 10 patients with a granulosa cell tumor during 6 to 47 months of follow-up.

RESULTS:

Serum antimüllerian hormone was undetectable in normal postmenopausal women and was <5 micrograms/L in premenopausal women. Normal serum levels were found in patients with ovarian cancers or cysts or with extraovarian cancers. Levels were between 6.8 and 117.9 microg/L in eight of nine patients with a progressive granulosa cell tumor. In the remaining case antimüllerian hormone, alpha-inhibin and estradiol concentrations were normal. Serum antimüllerian hormone and alpha-inhibin levels became elevated at least 11 months before the recurrence was clinically detectable. During clinical remission serum antimullerian hormone, beta-inhibin, and estradiol were normal in most cases.

CONCLUSION:

Serum antimüllerian hormone is a sensitive, specific, reliable marker of adult-type granulosa cell tumors and is useful to evaluate the efficacy of treatment and to detect recurrences early.

• Authors: R A Rey, C Lhommé, I Marcillac, N Lahlou, P Duvillard, N Josso, J M Bidart
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 174 Issue 3 Pg. 958-65 (Mar 1996) ISSN: 0002-9378 [Print] United States
• PMID: 8633676 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Glycoproteins
• Growth Inhibitors
• Peptides
• Testicular Hormones
• inhibin-alpha subunit
• Estradiol
• Inhibins
• Anti-Mullerian Hormone

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Mullerian Hormone
• Biomarkers, Tumor (blood)
• Estradiol (blood)
• Female
• Follow-Up Studies
• Glycoproteins
• Granulosa Cell Tumor (blood, diagnosis)
• Growth Inhibitors (blood)
• Humans
• Inhibins
• Middle Aged
• Ovarian Neoplasms (blood, diagnosis)
• Peptides (blood)
• Predictive Value of Tests
• Sensitivity and Specificity
• Testicular Hormones (blood)