Cyclin D and oncogenesis.

Abstract

The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene'), and breast and squamous cell cancers. The mechanism by which deregulated production of cyclin D1/PRAD1, and perhaps other D-type cyclins, contributes to tumor development is only beginning to be deciphered.

• Authors: T Motokura, A Arnold
• Journal: Current opinion in genetics & development (Curr Opin Genet Dev) Vol. 3 Issue 1 Pg. 5-10 (Feb 1993) ISSN: 0959-437X [Print] England
• PMID: 8453274 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Cyclins
• MAS1 protein, human
• Oncogene Proteins
• Proto-Oncogene Mas
• Cyclin D1

Topics

• Adenoma (genetics)
• Breast Neoplasms (genetics)
• Carcinoma, Squamous Cell (genetics)
• Cell Cycle (genetics)
• Cell Division
• Cell Transformation, Neoplastic (genetics)
• Cyclin D1
• Cyclins (genetics, physiology)
• Gene Expression Regulation, Neoplastic
• Humans
• Leukemia, B-Cell (genetics)
• Lymphoma, B-Cell (genetics)
• Multigene Family
• Oncogene Proteins (genetics, physiology)
• Parathyroid Neoplasms (genetics)
• Proto-Oncogene Mas
• Proto-Oncogenes