Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young.

Abstract

Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion from beta cells. The GLP-1 receptor is a candidate gene for diabetes mellitus, as mutations may induce the impaired insulin response that is a characteristic feature of NIDDM. To study the relationship between the GLP-1 receptor gene and NIDDM, linkage of a microsatellite polymorphism flanking the GLP-1 receptor gene with diabetes was investigated in three Caucasian families with MODY and in the nuclear families of 12 NIDDM probands. A cumulative LOD score -8.50 excludes linkage in these MODY pedigrees. A LOD score of -1.24 in the NIDDM nuclear pedigrees makes linkage improbable. Mutations in or near the GLP-1 receptor gene are unlikely to be the major cause of the inherited predisposition to NIDDM in Caucasian pedigrees, but we cannot exclude a role for this locus in a polygenic model or a major role in some pedigrees.

• Authors: Y Zhang, J T Cook, A T Hattersley, R Firth, P J Saker, M Warren-Perry, M Stoffel, R C Turner
• Journal: Diabetologia (Diabetologia) Vol. 37 Issue 7 Pg. 721-4 (Jul 1994) ISSN: 0012-186X [Print] Germany
• PMID: 7958545 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• GLP1R protein, human
• Glucagon-Like Peptide-1 Receptor
• Oligonucleotide Probes
• Receptors, Cell Surface
• Receptors, Glucagon
• DNA

Topics

• Base Sequence
• DNA (analysis)
• Diabetes Mellitus, Type 2 (genetics, metabolism)
• Electrophoresis, Polyacrylamide Gel
• Female
• Genes
• Genetic Linkage
• Glucagon-Like Peptide-1 Receptor
• Humans
• Lod Score
• Male
• Molecular Sequence Data
• Oligonucleotide Probes
• Pedigree
• Polymerase Chain Reaction
• Receptors, Cell Surface (genetics)
• Receptors, Glucagon