Cefetamet pivoxil in the treatment of uncomplicated gonorrhea.

Abstract

We studied the efficacy and safety of cefetamet pivoxil (CAT), an oral aminothiazolyl cephalosporin, in a series of open, comparative multicenter studies in 207 women (four study centers) with uncomplicated gonorrhea, and summarized and pooled the results with those of earlier open dose-finding trials (360 men; six study centers). We compared single-dose treatment regimen of CAT--over the range of 400-1500 mg--with spectinomycin, thiamphenicol, ampicillin, or amoxicillin plus probenecid. The overall cure rates were 100% in 88 women treated with 1500 mg CAT and in 137 men treated with 1200 or 1500 mg CAT, 98% (114 of 116 men) in those treated with 800 or 1000 mg CAT, and 93% (42 of 45 men) in those treated with 400 or 500 mg CAT; the composite cure rate of the comparators was 97%. The tolerability of CAT (n = 428) compared favorably (1.8% adverse events) with that of the standard drugs (n = 139) (4.3% adverse events). Single-dose treatment with 1500 mg CAT is effective and safe in adults with uncomplicated gonorrhea.

• Authors: R Lucena, C E Borges, L F Vieiralves, J M Kanga, P Hohl, M Zappelini, M Kissling
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 19 Issue 2 Pg. 121-7 (Jun 1994) ISSN: 0732-8893 [Print] United States
• PMID: 7805356 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• cefetamet
• Ceftizoxime

Topics

• Adolescent
• Adult
• Aged
• Ceftizoxime (adverse effects, analogs & derivatives, therapeutic use)
• Female
• Gonorrhea (drug therapy)
• Humans
• Male
• Middle Aged
• Prospective Studies