Abstract | OBJECTIVES: BACKGROUND: METHODS: The effects of 6 weeks of therapy with captopril (50 mg twice a day), enalapril (2.5 mg twice a day) or placebo on in vivo variables of left ventricular remodeling, function and mass (by echocardiography), hemodynamic function, postmortem topography (by planimetry) and collagen ( hydroxyproline levels) were studied in 36 instrumented dogs randomized to receive therapy 48 h after left anterior descending or left circumflex coronary artery occlusion. RESULTS: Compared with placebo therapy, both captopril and enalapril decreased infarct expansion and thinning, progressive ventricular dilation, ventricular mass and asynergy and infarct collagen levels in anterior and inferior infarcts. Despite similar small scar sizes, the effects on remodeling and dysfunction were greater in anterior than inferior infarcts. In addition, captopril produced greater attenuation of infarct expansion and ventricular enlargement, greater improvement in volume ejection fraction and less decrease in infarct collagen levels than enalapril. CONCLUSIONS:
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Authors | B I Jugdutt |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 25
Issue 7
Pg. 1718-25
(Jun 1995)
ISSN: 0735-1097 [Print] United States |
PMID | 7759729
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Enalapril
- Collagen
- Captopril
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Topics |
- Animals
- Captopril
(pharmacology)
- Collagen
(drug effects)
- Dogs
- Echocardiography
- Electrocardiography
- Enalapril
(pharmacology)
- Hemodynamics
(drug effects)
- Hypertrophy, Left Ventricular
(etiology, physiopathology, prevention & control)
- Myocardial Infarction
(complications, drug therapy, physiopathology)
- Systole
(drug effects)
- Time Factors
- Ventricular Function, Left
(drug effects)
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