The chorda tympani nerve (CT) has been shown to be critical in the
sodium-specific drinking behavior of
sodium-depleted rats, but the role of other gustatory nerves and the contribution of the major salivary glands remain to be elucidated. In this study, rats received either bilateral section of the CT (CTX) or the glossopharyngeal nerve (GLX), extirpation of the sublingual and submaxillary salivary glands (
DSAL), or
sham surgery. After recovery, rats were
sodium depleted with
furosemide and tested for their licking responses to 0.05 and 0.3 M NaCl, KCl, CaCl2, and NH4Cl, as well as distilled water in an automated gustometer. Rats that received GLX maintained a specific
sodium appetite comparable to controls despite
denervation of approximately 64% of the taste buds. In contrast, compared with control rats, CTX and
DSAL rats had altered response profiles, showing much smaller differences in licking to NaCl relative to the other stimuli. This was accompanied by a substantially lower lick rate in
DSAL rats, raising the possibility that general licking impairments contributed to the decreased NaCl responsiveness in these rats. These findings imply that the CT, but not the glossopharyngeal nerve, is necessary for the maintenance of normal
sodium-specific, taste-guided behavior under
sodium deplete conditions.