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Furosemide (Lasix)

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.

Also Known As:

Lasix; Errolon; Frusemid; Furanthril; Furantral; Furosemide Monohydrochloride; Furosemide Monosodium Salt; Fusid; Salix (brand of furosemide); Frusemide; Fursemide; Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)-

Networked: 3406 relevant articles (236 outcomes, 400 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Paterna, Salvatore: 8 articles (10/2015 - 03/2003)
2.	Parrinello, Gaspare: 8 articles (10/2015 - 03/2003)
3.	Di Pasquale, Pietro: 7 articles (04/2013 - 03/2003)
4.	O'Connor, Christopher M: 6 articles (09/2015 - 06/2010)
5.	Brion, L P: 6 articles (01/2008 - 01/2000)
6.	Nanas, John N: 5 articles (12/2015 - 12/2003)
7.	Voors, Adriaan A: 5 articles (10/2015 - 05/2011)
8.	Fasullo, Sergio: 5 articles (04/2013 - 01/2005)
9.	Licata, Giuseppe: 5 articles (04/2013 - 03/2003)
10.	Weber, Karl T: 5 articles (09/2006 - 09/2004)

Related Diseases

1.	Heart Failure 08/01/1996 - "In a randomized crossover study we compared the efficacy of a continuous infusion of high dose furosemide (mean daily dosage 690 mg, range 250 to 2,000) versus a single bolus injection of an equal dose in 20 patients with severe heart failure. " 08/01/1996 - "The efficacy of high dose furosemide as a continuous infusion was compared with a bolus injection of equal dose in patients with severe heart failure. " 08/01/1996 - "Diuretic efficacy of high dose furosemide in severe heart failure: bolus injection versus continuous infusion." 10/01/1990 - "High dose furosemide was effective for rapid removal of excess water and salt in "furosemide-resistant" congestive heart failure. " 05/01/2015 - "HSS as an adjunct to i.v. furosemide for diuretic-resistant CHF patients led to a better renal safety profile and improved clinical endpoints such as mortality and heart failure-related hospitalizations."
2.	Hypertension (High Blood Pressure) 04/01/2000 - "Thus, these data did not support the contention that administration of furosemide at intervals shorter than 4 h before exercise is more effective in attenuating exercise-induced pulmonary capillary or venous hypertension in Thoroughbred horses." 06/01/2015 - "In a large longitudinal prospective cohort study of mostly older white women, a history of hypertension and use of furosemide were associated with a significantly higher risk of developing P-HPTH." 06/01/2015 - "Among participants with a history of hypertension, the use of furosemide, when compared with the use of other antihypertensive medications, was associated with increased risk for developing P-HPTH; age-adjusted RR for incident P-HPTH was 1.79 (95% CI, 1.15-2.79) and multivariate-adjusted RR was 1.71 (95% CI, 1.08-2.71). " 03/01/2014 - "Hypertension (74 vs. 51 %, p = 0.0009), diabetes (49 vs. 30 %, p = 0.0046), and furosemide use (65 vs. 39 %, p = 0.0009) were more common in the nephrotoxic group. " 08/01/2011 - "Moreover, the administration of furosemide in vivo decreased the blood pressure and increased the urine output and natriuresis in MHS rats demonstrating the actual involvement of NKCC2 activity in the pathogenesis of hypertension in this strain of rats. "
3.	Acute Kidney Injury (Acute Renal Failure) 07/01/2015 - "Question 1: Is the use of furosemide beneficial in the treatment of acute kidney injury in the paediatric population including neonates?" 05/01/2002 - "Her postpartum course was complicated by acute renal failure that responded well to treatment with Lasix and Albumin. " 10/01/2015 - "Prevention of Acute Kidney Injury With the RenalGuard System in Patients Undergoing Transcatheter Aortic Valve Replacement: The PROTECT-TAVI Trial (PROphylactic effecT of furosEmide-induCed diuresis with matched isotonic intravenous hydraTion in Transcatheter Aortic Valve Implantation)." 10/01/2015 - "Acute Kidney Injury With the RenalGuard System in Patients Undergoing Transcatheter Aortic Valve Replacement: The PROTECT-TAVI Trial (PROphylactic effecT of furosEmide-induCed diuresis with matched isotonic intravenous hydraTion in Transcatheter Aortic Valve Implantation)." 08/26/2006 - "Stratifying studies that used frusemide to prevent or treat acute renal failure did not change the results on mortality (relative risk ratio 2.10, 95% confidence interval 0.67 to 6.63) and the risk for requiring dialysis (4.12, 0.46 to 37.2). "
4.	Ascites 01/01/2011 - "Patients with anasarca responded well to oral and intravenous furosemide, but those with isolated ascites did not. " 04/01/2012 - "Use of a short continuous furosemide infusion can achieve a FENa of 1% or greater in patients with cirrhotic ascites and may be safe and efficacious for diuresis, meriting further study." 12/01/2005 - "This study shows that HRS as defined by the International Ascites Club can be treated by albumin administration alone or with furosemide given according to the patient's specific need using CVP." 12/01/1967 - "Studies on furosemide: an effective oral saludiuretic for bilharzial ascites." 10/25/1965 - "[Clinical trials of a new salidiuretic, furosemide, in the treatment of cirrhotic ascites. "
5.	Edema 04/01/2007 - "Meta analysis showed that dextran-40 together with furosemide was effective for nephrotic edema. " 07/01/1984 - "Our data suggest the possibility that, before decreasing edema, furosemide improved shunt through pulmonary vascular effects by preferential perfusion of nonflooded alveolar units." 01/01/2014 - "Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial." 04/01/2005 - "In short-term studies, furosemide reduces edema, reduces hospitalizations, and improves exercise capacity in the setting of systolic dysfunction (strength of recommendation [SOR]: B, based upon low-quality randomized controlled trials). " 03/01/1987 - "A double-blind cross-over randomized clinical study with two different brands of furosemide was carried out in seven patients with edema of renal origin. "

Related Drugs and Biologics

1.	Spironolactone (Aldactone)
2.	torsemide (torasemide)
3.	Captopril (Capoten)
4.	Diuretics
5.	Creatinine
6.	Sodium
7.	Dopamine (Intropin)
8.	Glycerol (Glycerine)
9.	Renin
10.	Bumetanide (Bumex)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Oral Administration
3.	Fluid Therapy (Oral Rehydration Therapy)
4.	Intravenous Infusions
5.	Drug Therapy (Chemotherapy)