[Value of plasma exchange in the management of acute immunoallergic thrombocytopenic purpura (author's transl)].

Abstract

Plasma exchanges were performed in 5 patients with acute immunoallergic thrombocytopenic purpura (ITP) because of severe haemorrhages and/or inefficient or badly tolerated corticosteroid therapy. Plasma exchanges were carried out with cell separators and were usually well tolerated. They resulted in very rapid increase in platelet levels with disappearance of auto-antibodies and dramatic reduction of haemorrhages, and they brought about, or accelerated, recovery in 3 patients. One patient was slightly improved. In the 5th patient, who had meningeal haemorrhage, plasma exchange was effective in increasing platelet levels but was unable to prevent a fatal outcome. The main indications for plasma exchange seems to be acute ITP with severe, life-threatening haemorrhages.

• Authors: R Zittoun, S Bergeret, S Thierry, C Pillier, E Radeau-Coquin, A Bussel, G Bilski-Pasquier
• Journal: La Nouvelle presse medicale (Nouv Presse Med) Vol. 10 Issue 9 Pg. 683-8 (Feb 28 1981) ISSN: 0301-1518 [Print] France
• Vernacular Title: Intérêt des échanges plasmatiques dans le traitement des purpuras thrombopéniques immuno-allergiques aigus.
• PMID: 7193861 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies

Topics

• Acute Disease
• Adult
• Aged
• Antibodies (analysis)
• Female
• Humans
• Male
• Plasma Exchange
• Platelet Count
• Purpura, Thrombocytopenic (immunology, therapy)