[Oxidative enzyme activity of the tricarboxylic acid cycle in rat skeletal muscles in hypokinesia].

Abstract

The study of 165 rats exposed to 60-day hypokinesia demonstrated a decrease in the quantity of mitochondrial protein and a decline in the activity of mitochondrial forms of NADP-isocitrate dehydrogenase (NADP-ICDH) and NAD-malate dehydrogenase (NAD-MDH), as well as NAD-ICDH, succinate dehydrogenase (SDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH). The maximum decline in the protein content was seen on day 60, and in the enzyme activity on day 7. As the hypokinetic exposure continued, the activity of mitochondrial NAD-MDH and NADP-ICDH slightly increased. The NADP-MDH activity decreased only at later stages of hypokinesia. The changes in cytoplasmic NAD-MDH, NADP-ICDH and NADP-MDH were less expressed. On day 25 of the recovery period the activity of NAD-ICDH and NADP-ICDH was significantly higher than in the controls, that of mitochondrial NAD-MDH returned to the normal, and the activity of SDH and alpha-KGDH remained noticeably lowered.

• Authors: Iu A Ganin
• Journal: Kosmicheskaia biologiia i aviakosmicheskaia meditsina (Kosm Biol Aviakosm Med) 1982 Nov-Dec Vol. 16 Issue 6 Pg. 37-41 ISSN: 0321-5040 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' okislitel'nykh fermentov tsikla trikarbonovykh kislot v skeletnykh myshtsakh krys pri gipokinezii.
• PMID: 7176503 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Oxidoreductases

Topics

• Animals
• Citric Acid Cycle
• Cytoplasm (enzymology)
• Male
• Mitochondria, Muscle (enzymology)
• Muscles (enzymology)
• Oxidoreductases (metabolism)
• Rats
• Restraint, Physical
• Time Factors