Abstract |
The effect of SKF 525A (20 mg/kg i.v.) on pressor responses of various origin was studied. SKF 525A abolished or markedly reduced the pressor responses to ganglionic stimulants (DMPP and McN-A-343), but potentiated those to noradrenaline (in normal and pithed animals), adrenaline, tyramine, oxytocin and carotid occlusion. After recovery of the pressor effect of McN-A-343 from the SKF 525A-induced suppression, the pressor effect of noradrenaline was still further enhanced. The abolition of the pressor responses to ganglionic stimulants is due to the ganglion and adrenal-medullary blocking action of SKF 525A. This action of SKF 525A is of secondary importance for its potentiating effect. It is tentatively suggested that for the SKF 525A-induced potentiation a partial depolarization of arterial smooth muscle membrane resulting from a prolonged release of subthreshold concentrations of catecholamines from tissue stores, may be of primary importance.
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Authors | M K Krstić |
Journal | Archives internationales de pharmacodynamie et de therapie
(Arch Int Pharmacodyn Ther)
Vol. 269
Issue 1
Pg. 52-62
(May 1984)
ISSN: 0003-9780 [Print] Belgium |
PMID | 6466007
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Catecholamines
- Ganglionic Stimulants
- Oxytocin
- Dimethylphenylpiperazinium Iodide
- Proadifen
- Norepinephrine
- Tyramine
- Epinephrine
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Carotid Arteries
(physiology)
- Catecholamines
(pharmacology)
- Dimethylphenylpiperazinium Iodide
(pharmacology)
- Drug Synergism
- Epinephrine
(pharmacology)
- Female
- Ganglionic Stimulants
(pharmacology)
- Male
- Norepinephrine
(pharmacology)
- Oxytocin
(pharmacology)
- Proadifen
(pharmacology)
- Rats
- Rats, Inbred Strains
- Tyramine
(pharmacology)
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